Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Cécile Exertier"'
Autor:
Gabriele Cerutti, Elena Gugole, Linda Celeste Montemiglio, Annick Turbé-Doan, Dehbia Chena, David Navarro, Anne Lomascolo, François Piumi, Cécile Exertier, Ida Freda, Beatrice Vallone, Eric Record, Carmelinda Savino, Giuliano Sciara
Publikováno v:
Biotechnology for Biofuels, Vol 14, Iss 1, Pp 1-18 (2021)
Abstract Background Fungal glucose dehydrogenases (GDHs) are FAD-dependent enzymes belonging to the glucose-methanol-choline oxidoreductase superfamily. These enzymes are classified in the “Auxiliary Activity” family 3 (AA3) of the Carbohydrate-A
Externí odkaz:
https://doaj.org/article/a1f067b794c9420f9b981cab4f6f8594
Autor:
Annarita Fiorillo, Gianni Colotti, Cécile Exertier, Anastasia Liuzzi, Francesca Seghetti, Alessandra Salerno, Jessica Caciolla, Andrea Ilari
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Trypanothione reductase (TR) is a key factor in the redox homeostasis of trypanosomatid parasites, critical for survival in the hostile oxidative environment generated by the host to fight infection. TR is considered an attractive target for the deve
Externí odkaz:
https://doaj.org/article/4b2828d0298b44f59cd154685afc2200
Autor:
Maria Laura De Sciscio, Alessandro Nicola Nardi, Giacomo Parisi, Giovanni Bulfaro, Antonella Costanzo, Elena Gugole, Cécile Exertier, Ida Freda, Carmelinda Savino, Beatrice Vallone, Linda Celeste Montemiglio, Marco D’Abramo
Publikováno v:
Molecules, Vol 28, Iss 2, p 832 (2023)
Cytochrome P450 OleP catalytic activity is strongly influenced by its structural dynamic conformational behavior. Here, we combine equilibrium-binding experiments with all-atom molecular dynamics simulations to clarify how different environments affe
Externí odkaz:
https://doaj.org/article/1ddbac8529164a23955cefcf2c9bf90f
Autor:
Valentina Noemi Madia, Davide Ialongo, Elisa Patacchini, Cécile Exertier, Lorenzo Antonelli, Gianni Colotti, Antonella Messore, Valeria Tudino, Francesco Saccoliti, Luigi Scipione, Andrea Ilari, Roberta Costi, Roberto Di Santo
Publikováno v:
Molecules, Vol 28, Iss 1, p 338 (2023)
Background: As a result of the paucity of treatment, Leishmaniasis continues to provoke about 60,000 deaths every year worldwide. New molecules are needed, and drug discovery research is oriented toward targeting proteins crucial for parasite surviva
Externí odkaz:
https://doaj.org/article/d8108047186d4705909c3cdac555f968
Ligand pathways in neuroglobin revealed by low-temperature photodissociation and docking experiments
Autor:
Chiara Ardiccioni, Alessandro Arcovito, Stefano Della Longa, Peter van der Linden, Dominique Bourgeois, Martin Weik, Linda Celeste Montemiglio, Carmelinda Savino, Giovanna Avella, Cécile Exertier, Philippe Carpentier, Thierry Prangé, Maurizio Brunori, Nathalie Colloc'h, Beatrice Vallone
Publikováno v:
IUCrJ, Vol 6, Iss 5, Pp 832-842 (2019)
A combined biophysical approach was applied to map gas-docking sites within murine neuroglobin (Ngb), revealing snapshots of events that might govern activity and dynamics in this unique hexacoordinate globin, which is most likely to be involved in g
Externí odkaz:
https://doaj.org/article/3f979d12e1a148bca3f6ff79240f3987
Autor:
Marcello Miceli, Cécile Exertier, Marco Cavaglià, Elena Gugole, Marta Boccardo, Rossana Rita Casaluci, Noemi Ceccarelli, Alessandra De Maio, Beatrice Vallone, Marco A. Deriu
Publikováno v:
Biology, Vol 11, Iss 1, p 77 (2022)
Infantile-onset Ascending Hereditary Spastic Paralysis, Juvenile Primary Lateral Sclerosis and Juvenile Amyotrophic Lateral Sclerosis are all motor neuron diseases related to mutations on the ALS2 gene, encoding for a 1657 amino acids protein named A
Externí odkaz:
https://doaj.org/article/1686cfd31efe42d098ad012fce86b81d
Autor:
Mariano Maffei, Linda Celeste Montemiglio, Grazia Vitagliano, Luigi Fedele, Shaila Sellathurai, Federica Bucci, Mirco Compagnone, Valerio Chiarini, Cécile Exertier, Alessia Muzi, Giuseppe Roscilli, Beatrice Vallone, Emanuele Marra
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1812 (2021)
COVID-19 is a highly infectious disease caused by a newly emerged coronavirus (SARS-CoV-2) that has rapidly progressed into a pandemic. This unprecedent emergency has stressed the significance of developing effective therapeutics to fight the current
Externí odkaz:
https://doaj.org/article/af5296f4183347728d8f456fd9719f2b
Autor:
Linda Celeste Montemiglio, Elena Gugole, Ida Freda, Cécile Exertier, Lucia D’Auria, Cheng Giuseppe Chen, Alessandro Nicola Nardi, Gabriele Cerutti, Giacomo Parisi, Marco D’Abramo, Carmelinda Savino, Beatrice Vallone
Publikováno v:
Biomolecules, Vol 12, Iss 1, p 55 (2021)
Substrate binding to the cytochrome P450 OleP is coupled to a large open-to-closed transition that remodels the active site, minimizing its exposure to the external solvent. When the aglycone substrate binds, a small empty cavity is formed between th
Externí odkaz:
https://doaj.org/article/014bc032eab746b1a328dd4a15cdb350
Autor:
Giacomo Parisi, Ida Freda, Cécile Exertier, Cristina Cecchetti, Elena Gugole, Gabriele Cerutti, Lucia D’Auria, Alberto Macone, Beatrice Vallone, Carmelinda Savino, Linda Celeste Montemiglio
Publikováno v:
Biomolecules, Vol 10, Iss 10, p 1411 (2020)
The cytochrome P450 OleP catalyzes the epoxidation of aliphatic carbons on both the aglycone 8.8a-deoxyoleandolide (DEO) and the monoglycosylated L-olivosyl-8.8a-deoxyoleandolide (L-O-DEO) intermediates of oleandomycin biosynthesis. We investigated t
Externí odkaz:
https://doaj.org/article/41af8a0b5e574c6e803d9e5b65ebcf7a
Autor:
Cécile Exertier, Federico Sebastiani, Ida Freda, Elena Gugole, Gabriele Cerutti, Giacomo Parisi, Linda Celeste Montemiglio, Maurizio Becucci, Cristiano Viappiani, Stefano Bruno, Carmelinda Savino, Carlotta Zamparelli, Massimiliano Anselmi, Stefania Abbruzzetti, Giulietta Smulevich, Beatrice Vallone
Publikováno v:
ACS Chemical Biology. 17:2099-2108
We produced a neuroglobin variant, namely, Ngb CDless, with the excised CDloop- and D-helix, directly joining the C- and E-helices. The CDless variant retained bis-His hexacoordination, and we investigated the role of the CDloop-D-helix unit in contr