Low fluid shear stress stimulates the uptake of noxious endothelial extracellular vesicles via MCAM and PECAM‐1 cell adhesion molecules

Autor: Pierre‐Michaël Coly, Shruti Chatterjee, Fariza Mezine, Christelle El Jekmek, Cécile Devue, Thomas Nipoti, Stephane Mazlan, Maribel Lara Corona, Florent Dingli, Damarys Loew, Guillaume vanNiel, Xavier Loyer, Chantal M. Boulanger

Publikováno v: Journal of Extracellular Vesicles, Vol 13, Iss 10, Pp n/a-n/a (2024)

Abstract Atherosclerotic lesions mainly form in arterial areas exposed to low shear stress (LSS), where endothelial cells express a senescent and inflammatory phenotype. Conversely, areas exposed to high shear stress (HSS) are protected from plaque d

Externí odkaz: https://doaj.org/article/343c9ce5c11a493fb14c4f70b7281a6b

Endothelial shear stress affects extracellular vesicle release and biodistribution

Autor: Chantal M. Boulanger, M. Robillard, Pierre-Michael Coly, Xavier Loyer, Cécile Devue

Publikováno v: Archives of Cardiovascular Diseases Supplements. 12:202

Introduction Atheroscleroris (AS) is a risk factor of cardiovascular disease (CVD). AS initiates at the endothelial level in areas of perturbed blood flow contributing to the recruitment of inflammatory cells. Extracellular vesicles (EVs) have emerge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89b16abb4d6602eb938d5f50376a44dc
https://doi.org/10.1016/j.acvdsp.2020.03.008

Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow

Autor: Johanna Busse, Juliette Lasselin, Benoit Viollet, Xavier Loyer, Alain Tedgui, Patrice Codogno, Marouane Kheloufi, Johanne Poisson, Michele Souyri, Pierre Julia, Nicolas Dupont, Isabelle Pic, Konstantin Stark, Cécile Devue, Abdul I. Barakat, Anne-Clémence Vion, Adel Hammoutene, Julie Lafaurie-Janvore, Chantal M. Boulanger, Pierre-Emmanuel Rautou

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (41), pp.E8675-E8684. ⟨10.1073/pnas.1702223114⟩
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (41), pp.E8675-E8684. ⟨10.1073/pnas.1702223114⟩

International audience; It has been known for some time that atherosclerotic lesions preferentially develop in areas exposed to low SS and are characterized by a proinflammatory, apoptotic, and senescent endothelial phenotype. Conversely, areas expos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b01f6e6b7622c1bc0a495874f6d4fd
https://doi.org/10.1073/pnas.1702223114

Endothelial autophagic flux hampers atherosclerotic lesion development

Autor: Pierre Julia, Adel Hammoutene, Isabelle Pic, Benoit Viollet, Marouane Kheloufi, Patrice Codogno, Johanne Poisson, Konstantin Stark, Anne-Clémence Vion, Nicolas Dupont, Cécile Devue, Michele Souyri, Alain Tedgui, Julie Lafaurie-Janvore, Abdul I. Barakat, Juliette Lasselin, Pierre-Emmanuel Rautou, Johanna Busse, Xavier Loyer, Chantal M. Boulanger

Publikováno v: Autophagy
Autophagy, 2017, 14 (1), pp.173-175. ⟨10.1080/15548627.2017.1395114⟩
Autophagy, Taylor & Francis, 2017, 14 (1), pp.173-175. ⟨10.1080/15548627.2017.1395114⟩

International audience; Blood flowing in arteries generates shear forces at the surface of the vascular endothelium that control its anti-atherogenic properties. However, due to the architecture of the vascular tree, these shear forces are heterogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0d11e12999ff3ad16eebbe1d162766
https://www.hal.inserm.fr/inserm-02349918

A prospective study of the utility of plasma biomarkers to diagnose alcoholic hepatitis

Autor: Pau Sancho-Bru, François Durand, Pierre Bedossa, Didier Lebrec, Hafid Ait-Oufella, Dominique Valla, Ramon Bataller, Chantal M. Boulanger, Pere Ginès, Julien Bissonnette, José Altamirano, Joan Caballería, Olivier Roux, Audrey Payancé, Cécile Devue, Pierre-Emmanuel Rautou

Publikováno v: Hepatology (Baltimore, Md.). 66(2)

The diagnosis of alcoholic hepatitis (AH) often requires a transjugular liver biopsy (TJLB), a procedure that is not always readily accessible. We analyzed plasma biomarkers to estimate the presence of histological features of AH among patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b99cc6124b501edd3ceedad940a0a46
https://pubmed.ncbi.nlm.nih.gov/28941362