Differential impact of genetic deletion of TIGIT or PD-1 on melanoma-specific T-lymphocytes

Autor: Gwenann Cadiou, Tiffany Beauvais, Lucine Marotte, Sylvia Lambot, Cécile Deleine, Caroline Vignes, Malika Gantier, Melanie Hussong, Samuel Rulli, Anne Jarry, Sylvain Simon, Bernard Malissen, Nathalie Labarriere

Publikováno v: OncoImmunology, Vol 13, Iss 1 (2024)

Immune checkpoint (IC) blockade and adoptive transfer of tumor-specific T-cells (ACT) are two major strategies to treat metastatic melanoma. Their combination can potentiate T-cell activation in the suppressive tumor microenvironment, but the autoimm

Externí odkaz: https://doaj.org/article/340606cf6c7041f6bba4cce82a0f24d4

The density of Tbet+ tumor-infiltrating T lymphocytes reflects an effective and druggable preexisting adaptive antitumor immune response in colorectal cancer, irrespective of the microsatellite status

Autor: Eva Ott, Linda Bilonda, Delphine Dansette, Cécile Deleine, Emilie Duchalais, Juliette Podevin, Christelle Volteau, Jaafar Bennouna, Yann Touchefeu, Pierre Fourquier, Wassila El Alami Thomas, Jérome Chetritt, Stéphane Bezieau, Marc Denis, Claire Toquet, Jean-François Mosnier, Anne Jarry, Céline Bossard

Publikováno v: OncoImmunology, Vol 8, Iss 4 (2019)

Purpose: The recent success of anti-PD1 antibody in metastatic colorectal cancer (CRC) patients with microsatellite instability (MSI), known to be associated with an upregulated Th1/Tc1 gene signature, provides new promising therapeutic strategies. H

Externí odkaz: https://doaj.org/article/b6672e6a5fb046ef950dbefa88542634

The inhibitory receptor CD94/NKG2A on CD8 + tumor-infiltrating lymphocytes in colorectal cancer: a promising new druggable immune checkpoint in the context of HLAE/β2m overexpression

Autor: Guillaume Meurette, Tamara Matysiak, Christelle Volteau, Stéphane Bézieau, Claire Toquet, Wassila El Alami Thomas, Jerome Chetritt, Jaafar Bennouna, Emilie Thibaudeau, Jean-François Mosnier, Cécile Deleine, Juliette Eugene, Kathleen Ducoin, Romain Oger, Nicolas Jouand, Frédéric Dumont, Edouard Leveque, Nadine Gervois, Olivier Kerdraon, Pierre Fourquier, Céline Bossard, Anne Jarry, Delphine Dansette, Juliette Podevin

Publikováno v: Modern Pathology
Modern Pathology, Nature Publishing Group: Open Access Hybrid Model Option B, 2019, Epub ahead of print. ⟨10.1038/s41379-019-0322-9⟩
Modern Pathology, 2019, Epub ahead of print. ⟨10.1038/s41379-019-0322-9⟩

International audience; We previously demonstrated that HLA-E/β2m overexpression by tumor cells in colorectal cancers is associated with an unfavorable prognosis. However, the expression of its specific receptor CD94/NKG2 by intraepithelial tumor-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b4d0c73269f7a599be98e580a55e39
https://www.hal.inserm.fr/inserm-02281341/file/Gervois2019Eq3.pdf

Abstract 4061: The inflammasome of tumor cells modulates the biology of tumor-infiltrating T lymphocytes in colorectal cancer

Autor: Anne Jarry, Cécile Deleine, Delphine Dansette, Jean-François Mosnier, Jerome Chetritt, Céline Bossard, Nadine Gervois, Linda Bilonda, Romain Oger, Pierre Fourquier, Emilie Thibaudeau, Nicolas Jouand, Juliette Podevin

Publikováno v: Cancer Research. 78:4061-4061

In colorectal cancer (CRC), little is known about mechanisms by which tumor cells can influence the biology of Tumor Infiltrating T lymphocytes (TILs) present in the tumor microenvironment. One of these mechanisms could be modulation of the inflammas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b7034676aa9f315399a88ae8b58ffc9
https://doi.org/10.1158/1538-7445.am2018-4061

Implementation of the EGFP-K562 flow cytometric NK test: determination of NK cytotoxic activity in healthy elderly volunteers before and after feeding

Autor: Yves Boirie, Marie-Paule Vasson, Séverine Allegra, Wannee Kantakamalakul, Céline Gryson, Cécile Deleine, Rime Michael-Jubely

Publikováno v: Cytometry. Part A : the journal of the International Society for Analytical Cytology. 69(9)

Background: Natural Killer (NK) cells are key actors of innate immunity that supervise the organism's cells, and fight against viral infections and cancer development through their cytotoxic activity. This cytotoxic activity is modulated by cytokines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541eefc902d91ca680e6f0f0180df1ae
https://pubmed.ncbi.nlm.nih.gov/16969797