Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Cécile Bussetta"'
1
Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues
Autor: Cécile Bussetta, Karine Barral, Bruno Canard, Karine Alvarez, Antoine Frangeul, Jerome Deval
Publikováno v: Antiviral Therapy
Antiviral Therapy, International Medical Press, 2019, 13 (1), pp.115-24
Antiviral Therapy, 2019, 13 (1), pp.115-24
BackgroundIn the treatment of HIV, the loose active site of the HIV-1 reverse transcriptase (RT) allows numerous nucleotide analogues to act as proviral DNA ‘chain-terminators’. Acyclic nucleotide phosphonate analogues (ANPs) represent a particul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7703d381b2c6a6737c63d9c4c54b24a
https://hal-amu.archives-ouvertes.fr/hal-02061712
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2
Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step
Autor: Françoise Guéritte, Cécilia Eydoux, Stephane Betzi, Cécile Bussetta, Mohamed Ben-Rahou, Jean-Louis Romette, Marilyne Blémont, Xavier Morelli, Bruno Canard, Hélène Dutartre, Johan Neyts, Marcel Hibert, Jean-Claude Guillemot, Karine Alvarez, Claire Debarnot, David S. Grierson, Pieter Leyssen, Jacques Haiech
Publikováno v: Antiviral Research
Antiviral Research, Elsevier Masson, 2009, 84 (1), pp.48-59. ⟨10.1016/j.antiviral.2009.06.009⟩
International audience; Hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B constitutes a target of choice for the development of anti-HCV drugs. Although many small molecules have been identified as allosteric inhibitors of NS5B, very few are
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24de250a22ed85b737fc5af00b24a2d
https://doi.org/10.1016/j.antiviral.2009.06.009
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3
The Crystal Structure of Coxsackievirus B3 RNA-Dependent RNA Polymerase in Complex with Its Protein Primer VPg Confirms the Existence of a Second VPg Binding Site on Picornaviridae Polymerases
Autor: Gérard Bricogne, Ilham Jabafi, Michael S. Roberts, Bruno Coutard, Cécile Bussetta, Johan Neyts, Bruno Canard, Armando M. De Palma, Arnaud Gruez, Barbara Selisko
Publikováno v: Journal of Virology. 82:9577-9590
The RNA-dependent RNA polymerase (RdRp) is a central piece in the replication machinery of RNA viruses. In picornaviruses this essential RdRp activity also uridylates the VPg peptide, which then serves as a primer for RNA synthesis. Previous genetic,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674035438b982a48883603b7db10f3ec
https://doi.org/10.1128/jvi.00631-08
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4
A second, non-canonical RNA-dependent RNA polymerase in SARS Coronavirus
Autor: Bruno Canard, Bruno Coutard, Isabelle Imbert, François Ferron, Jean Marie Bourhis, Jean-Claude Guillemot, Cécile Bussetta, Alexander E. Gorbalenya, M P Egloff
Publikováno v: The EMBO Journal
In (+) RNA coronaviruses, replication and transcription of the giant approximately 30 kb genome to produce genome- and subgenome-size RNAs of both polarities are mediated by a cognate membrane-bound enzymatic complex. Its RNA-dependent RNA polymerase
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0641bde751077c03e9d1f73141baaea5
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5
Inhibition of Dog and Human Gastric Lipases by Enantiomeric Phosphonate Inhibitors: A Structure−Activity Study
Autor: Mireille Rivière, Nabil Miled, Cécile Bussetta, Christian Cambillau, Liliane Berti-Dupuis, Gérard Buono, Alain Roussel, Robert Verger, Stéphane Canaan
Publikováno v: Biochemistry. 42:11587-11593
The crystal structures of gastric lipases in the apo form [Roussel, A., et al. (1999) J. Biol. Chem. 274, 16995-17002] or in complex with the (R(P))-undecyl butyl phosphonate [C(11)Y(4)(+)] [Roussel, A., et al. (2002) J. Biol. Chem. 277, 2266-2274] h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c586f8e3062ccc111c4b020e5c711d
https://doi.org/10.1021/bi034964p
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6
Importance of the lid and cap domains for the catalytic activity of gastric lipases
Autor: Cécile Bussetta, Mireille Rivière, L. Berti, Stéphane Canaan, Nabil Miled, A. De Caro
Publikováno v: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 136:131-138
Human gastric lipase (HGL) is an enzyme secreted by the stomach, which is stable and active despite the highly acidic environment. It has been clearly established that this enzyme is responsible for 30% of the fat digestion processes occurring in hum
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67869a1b24e1bab86208607415223842
https://doi.org/10.1016/s1096-4959(03)00183-0
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7
General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues
Autor: Bruno Canard, Hélène Dutartre, Joëlle Boretto, Cécile Bussetta
Publikováno v: Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, 2006, 50 (12), pp.4161-4169. ⟨10.1128/AAC.00433-06⟩
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2006, 50 (12), pp.4161-4169. ⟨10.1128/AAC.00433-06⟩
The hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B is an important target for antiviral therapies. NS5B is able to initiate viral RNA synthesis de novo and then switch to a fast and processive RNA elongation synthesis mode. The nucleotide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a4e6c1ddfcec64c65bcc019b969b29
https://hal.science/hal-02459219
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8
The modeled structure of the RNA dependent RNA polymerase of GBV-C Virus suggests a role for motif E in Flaviviridae RNA polymerases
Autor: Hélène Dutartre, Cécile Bussetta, Bruno Canard, François Ferron
Publikováno v: BMC Bioinformatics, Vol 6, Iss 1, p 255 (2005)
BMC Bioinformatics
BMC Bioinformatics, 2005, 6 (1), pp.255. ⟨10.1186/1471-2105-6-255⟩
BMC Bioinformatics, BioMed Central, 2005, 6 (1), pp.255. ⟨10.1186/1471-2105-6-255⟩
Background The Flaviviridae virus family includes major human and animal pathogens. The RNA dependent RNA polymerase (RdRp) plays a central role in the replication process, and thus is a validated target for antiviral drugs. Despite the increasing st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f291ddc4a457691d101b463f3e2c041e
https://doi.org/10.1186/1471-2105-6-255
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10
Akademický článek
Biochemical and Biophysical Characterization of the dsDNA Packaging Motor from the Lactococcus lactis Bacteriophage Asccphi28
Autor: Emilio Reyes-Aldrete, Erik A. Dill, Cecile Bussetta, Michal R. Szymanski, Geoffrey Diemer, Priyank Maindola, Mark A. White, Wlodzimierz M. Bujalowski, Kyung H. Choi, Marc C. Morais
Publikováno v: Viruses, Vol 13, Iss 1, p 15 (2020)
Double-stranded DNA viruses package their genomes into pre-assembled protein procapsids. This process is driven by macromolecular motors that transiently assemble at a unique vertex of the procapsid and utilize homomeric ring ATPases to couple genome
Externí odkaz: https://doaj.org/article/5d2cc0d9e5a8459aacb41316ef643805
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