Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Cécile, Martinat"'
Autor:
Shaqraa Musawi, Lise-Marie Donnio, Zehui Zhao, Charlène Magnani, Phoebe Rassinoux, Olivier Binda, Jianbo Huang, Arnaud Jacquier, Laurent Coudert, Patrick Lomonte, Cécile Martinat, Laurent Schaeffer, Denis Mottet, Jocelyn Côté, Pierre-Olivier Mari, Giuseppina Giglia-Mari
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Spinal muscular atrophy is an autosomal recessive neuromuscular disease caused by mutations in the multifunctional protein Survival of Motor Neuron, or SMN. Within the nucleus, SMN localizes to Cajal bodies, which are associated with nucleol
Externí odkaz:
https://doaj.org/article/50248904959c4a86860e553b2d011862
Autor:
Diana M. Dincã, Louison Lallemant, Anchel González-Barriga, Noémie Cresto, Sandra O. Braz, Géraldine Sicot, Laure-Elise Pillet, Hélène Polvèche, Paul Magneron, Aline Huguet-Lachon, Hélène Benyamine, Cuauhtli N. Azotla-Vilchis, Luis E. Agonizantes-Juárez, Julie Tahraoui-Boris, Cécile Martinat, Oscar Hernández-Hernández, Didier Auboeuf, Nathalie Rouach, Cyril F. Bourgeois, Geneviève Gourdon, Mário Gomes-Pereira
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Myotonic dystrophy type 1 (DM1) is characterized by debilitating neurological symptoms. Dinca et al. demonstrate the pronounced impact of DM1 on the morphology and RNA metabolism of astrocytes. Their findings suggest astroglial pathology in DM1 brain
Externí odkaz:
https://doaj.org/article/b8326071658541fb95db0b3ac8971f3d
Autor:
Juliette Duchesne de Lamotte, Jérôme Polentes, Florine Roussange, Léa Lesueur, Pauline Feurgard, Anselme Perrier, Camille Nicoleau, Cécile Martinat
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-17 (2021)
Abstract Background The lack of physiologically relevant and predictive cell-based assays is one of the major obstacles for testing and developing botulinum neurotoxins (BoNTs) therapeutics. Human-induced pluripotent stem cells (hiPSCs)-derivatives n
Externí odkaz:
https://doaj.org/article/a5bd460c5d7049d49b9f09415d55b45e
Publikováno v:
Cells, Vol 12, Iss 4, p 571 (2023)
Myotonic dystrophy type 1 (DM1) is a progressive multisystemic disease caused by the expansion of a CTG repeat tract within the 3′ untranslated region (3′ UTR) of the dystrophia myotonica protein kinase gene (DMPK). Although DM1 is considered to
Externí odkaz:
https://doaj.org/article/d83bb0d9a77045a28ae4d89170594ab0
Autor:
Margot Jarrige, Hélène Polvèche, Alexandre Carteron, Stéphane Janczarski, Marc Peschanski, Didier Auboeuf, Cécile Martinat
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102767- (2021)
Summary: Human pluripotent stem cells have ushered in an exciting new era for disease modeling, drug discovery, and cell therapy development. Continued progress toward realizing the potential of human pluripotent stem cells will be facilitated by rob
Externí odkaz:
https://doaj.org/article/83ea27fd2045444ab72f2778c0b79e29
Autor:
Pauline Georges, Maria-Gabriela Boza-Moran, Jacqueline Gide, Georges Arielle Pêche, Benjamin Forêt, Aurélien Bayot, Pierre Rustin, Marc Peschanski, Cécile Martinat, Laetitia Aubry
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Abstract Translation of pharmacological results from in vitro cell testing to clinical trials is challenging. One of the causes that may underlie these discrepant results is the lack of the phenotypic or species-specific relevance of the tested cells
Externí odkaz:
https://doaj.org/article/adf0e1a8e1024a7a8c3f6f7fe9edf703
Autor:
Yves Maury, Pauline Poydenot, Benjamin Brinon, Lea Lesueur, Jacqueline Gide, Sylvain Roquevière, Julien Côme, Hélène Polvèche, Didier Auboeuf, Jérome Alexandre Denis, Geneviève Pietu, Denis Furling, Marc Lechuga, Sandrine Baghdoyan, Marc Peschanski, Cécile Martinat
Publikováno v:
iScience, Vol 11, Iss , Pp 258-271 (2019)
Summary: There is currently no treatment for myotonic dystrophy type 1 (DM1), the most frequent myopathy of genetic origin. This progressive neuromuscular disease is caused by nuclear-retained RNAs containing expanded CUG repeats. These toxic RNAs al
Externí odkaz:
https://doaj.org/article/11e934f15b8347d3af89003142c3acd6
Autor:
Diana M. Dincã, Louison Lallemant, Anchel González-Barriga, Noémie Cresto, Sandra O. Braz, Géraldine Sicot, Laure-Elise Pillet, Hélène Polvèche, Paul Magneron, Aline Huguet-Lachon, Hélène Benyamine, Cuauhtli N. Azotla-Vilchis, Luis E. Agonizantes-Juárez, Julie Tahraoui-Bories, Cécile Martinat, Oscar Hernández-Hernández, Didier Auboeuf, Nathalie Rouach, Cyril F. Bourgeois, Geneviève Gourdon, Mário Gomes-Pereira
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/38ea75853dc34e0c869d60f3421b8a42
Autor:
Susie Barbeau, Romain Desprat, Bruno Eymard, Cécile Martinat, Jean-Marc Lemaitre, Claire Legay
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102106- (2020)
Congenital myasthenic syndromes (CMS) are a class of inherited disorders affecting the neuromuscular junction, a synapse whose activity is essential for movement. CMS with acetylcholinesterase (AChE) deficiency are caused by mutations in COLQ, a coll
Externí odkaz:
https://doaj.org/article/52966dba66814bcb9e8ab2d0eeb1a89f
Autor:
Manoubia Saidani, Annabelle Darle, Margot Jarrige, Hélène Polveche, Lina El Kassar, Séverine Julié, Sandrine Bessou-Touya, Nathalie Holic, Gilles Lemaitre, Cécile Martinat, Christine Baldeschi, Jennifer Allouche
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 7; Pages: 6398
Melanocytes are essential for skin homeostasis and protection, and their loss or misfunction leads to a wide spectrum of diseases. Cell therapy utilizing autologous melanocytes has been used for years as an adjunct treatment for hypopigmentary disord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a36ec13029e61256717e21ab955b4a