Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Cécile, Häberli"'
Autor:
Anna E. van Beek, Hannah Jeanguenat, Cécile Häberli, Richard B. Pouw, Christina Lamers, Gábor Pál, Péter Gál, Christoph Q. Schmidt, Daniel Ricklin, Jennifer Keiser
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundSchistosomes are highly efficient evaders of human immunity, as evident by their ability to survive in human blood for years. How they protect themselves against the constant attack by a key element of innate immunity, the complement system
Externí odkaz:
https://doaj.org/article/57c8f723b6b34a32a74928707eb54f8b
Autor:
Elena Cesar-Rodo, Baptiste Dupouy, Cécile Häberli, Jean-Marc Strub, David L. Williams, Pascal Mäser, Matthias Rottmann, Jennifer Keiser, Don Antoine Lanfranchi, Elisabeth Davioud-Charvet
Publikováno v:
Molecules, Vol 29, Iss 22, p 5268 (2024)
Ψ-1,4-naphthoquinones (Ψ-NQ) are non-quinoid compounds in which aromaticity—found in 1,4-naphthoquinones—is broken by the introduction of an angular methyl at C-4a or -8a. This series was designed to act as prodrugs of 1,4-naphthoquinones in an
Externí odkaz:
https://doaj.org/article/cded9c06b8374dad9697e51b4130bc42
Autor:
Harrison T. Shanley, Aya C. Taki, Nghi Nguyen, Tao Wang, Joseph J. Byrne, Ching-Seng Ang, Michael G. Leeming, Shuai Nie, Nicholas Williamson, Yuanting Zheng, Neil D. Young, Pasi K. Korhonen, Andreas Hofmann, Bill C.H. Chang, Tim N.C. Wells, Cécile Häberli, Jennifer Keiser, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 24, Iss , Pp 100522- (2024)
Within the context of our anthelmintic discovery program, we recently identified and evaluated a quinoline derivative, called ABX464 or obefazimod, as a nematocidal candidate; synthesised a series of analogues which were assessed for activity against
Externí odkaz:
https://doaj.org/article/bd1202bcf63a4ff0ade2f378a914072b
Autor:
Deryl Nii Okantey Kuevi, Jennifer Keiser, Cécile Häberli, Abena Konadu Owusu-Senyah, Mawutor Kwame Ahiabu
Publikováno v:
Journal of Tropical Medicine, Vol 2024 (2024)
Background. Schistosomiasis is caused by parasitic flatworms and the disease is endemic to most countries in sub-Saharan Africa including Ghana. The current therapeutic agent for managing this disease solely relies on praziquantel. The continual depe
Externí odkaz:
https://doaj.org/article/4beadcb3be5b4097b5192ead812ac7d3
Autor:
Andrea Angeli, Marta Ferraroni, Fabrizio Carta, Cécile Häberli, Jennifer Keiser, Gabriele Costantino, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1479-1494 (2022)
The almost empty armamentarium to treat schistosomiasis, a neglected parasitic disorder caused by trematode flatworms of the genus Schistosoma, except Praziquantel (PZQ), urged to find new alternatives to fight this infection. Carbonic Anhydrase from
Externí odkaz:
https://doaj.org/article/0d1fc72355e544a085b8deb92c83d2c0
Autor:
Elora Valderas-García, Cécile Häberli, María Álvarez-Bardón, Nerea Escala, Verónica Castilla-Gómez de Agüero, Jennifer de la Vega, Esther del Olmo, Rafael Balaña-Fouce, Jennifer Keiser, María Martínez-Valladares
Publikováno v:
Parasites & Vectors, Vol 15, Iss 1, Pp 1-8 (2022)
Abstract Background Infections by gastrointestinal nematodes cause significant economic losses and disease in both humans and animals worldwide. The discovery of novel anthelmintic drugs is crucial for maintaining control of these parasitic infection
Externí odkaz:
https://doaj.org/article/ad189a20cf4640cc9b5b90783cd1c11f
Autor:
Pierre H. H. Schneeberger, Morgan Gueuning, Sophie Welsche, Eveline Hürlimann, Julian Dommann, Cécile Häberli, Jürg E. Frey, Somphou Sayasone, Jennifer Keiser
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Little is known about the cause of treatment failure of soil-transmitted helminth infections. Here, the authors show that pre-treatment gut microbial community composition enables predicting treatment outcome for Trichuris trichiura and hookworm infe
Externí odkaz:
https://doaj.org/article/dde545b2a146481aa836cb65dcd99e67
Autor:
Jennifer Keiser, Cécile Häberli
Publikováno v:
Parasites & Vectors, Vol 14, Iss 1, Pp 1-7 (2021)
Abstract Background Infections with Strongyloides stercoralis belong to the most neglected helminth diseases, and research and development (R&D) efforts on novel drugs are inadequate. Methods A commercially available library containing 1600 FDA-appro
Externí odkaz:
https://doaj.org/article/1521cc45d0f04e6ca61233e0963dc10f
Autor:
Aya C. Taki, Tao Wang, Nghi N. Nguyen, Ching-Seng Ang, Michael G. Leeming, Shuai Nie, Joseph J. Byrne, Neil D. Young, Yuanting Zheng, Guangxu Ma, Pasi K. Korhonen, Anson V. Koehler, Nicholas A. Williamson, Andreas Hofmann, Bill C. H. Chang, Cécile Häberli, Jennifer Keiser, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Parasitic roundworms (nematodes) cause destructive diseases, and immense suffering in humans and other animals around the world. The control of these parasites relies heavily on anthelmintic therapy, but treatment failures and resistance to these dru
Externí odkaz:
https://doaj.org/article/9c2e2b7509564909be768e1c02e98074
Publikováno v:
Molecules, Vol 28, Iss 13, p 5184 (2023)
Malaria and schistosomiasis are two of the neglected tropical diseases that persistently wreak havoc worldwide. Although many antimalarial drugs such as chloroquine are readily available, the emergence of drug resistance necessitates the development
Externí odkaz:
https://doaj.org/article/611a645d534549179fd884d30a12ac77