Loss of seryl-tRNA synthetase ( SARS1 ) causes complex spastic paraplegia and cellular senescence

Autor: Edgard Verdura, Bruno Senger, Miquel Raspall-Chaure, Agatha Schlüter, Nathalie Launay, Montserrat Ruiz, Carlos Casasnovas, Agustí Rodriguez-Palmero, Alfons Macaya, Hubert Dominique Becker, Aurora Pujol

Publikováno v: Journal of Medical Genetics
Journal of Medical Genetics, BMJ Publishing Group, 2022, pp.jmedgenet-2022-108529. ⟨10.1136/jmg-2022-108529⟩
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Scientia

Genetic research; Nervous system diseases; Pediatrics Investigación genética; Enfermedades del sistema nervioso; Pediatría Recerca genètica; Malalties del sistema nerviós; Pediatria Background Aminoacyl-tRNA synthetases (ARS) are key enzymes cat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e157b3dabf7b32caad15107341db39a3
https://hal.archives-ouvertes.fr/hal-03798206/document

Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming

Autor: Dafni Chondronasiou, Diljeet Gill, Lluc Mosteiro, Rocio G. Urdinguio, Antonio Berenguer‐Llergo, Mònica Aguilera, Sylvere Durand, Fanny Aprahamian, Nitharsshini Nirmalathasan, Maria Abad, Daniel E. Martin‐Herranz, Camille Stephan‐Otto Attolini, Neus Prats, Guido Kroemer, Mario F. Fraga, Wolf Reik, Manuel Serrano

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Scopus
Scientia
RUO. Repositorio Institucional de la Universidad de Oviedo
instname

The expression of the pluripotency factors OCT4, SOX2, KLF4, and MYC (OSKM) can convert somatic differentiated cells into pluripotent stem cells in a process known as reprogramming. Notably, partial and reversible reprogramming does not change cell i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6722cd36b3762c85823aa9111c6f1a6f
http://hdl.handle.net/2445/184013

Linking in vitro models of endothelial dysfunction with cell senescence

Autor: Àngela Vea Badenes, Manel Sabaté Tenas, Joaquim Bobi Gibert, Francisco R. Jimenez Trinidad, Ana Paula Dantas, Marta Arrieta Ruiz, Montserrat Rigol Muxart, Antoni Valera Cañellas, Mercè Roqué Moreno, Olga Tura-Ceide, Xavier Freixa Rofastes, Núria Solanes Batlló

Publikováno v: Life, 11(12):1323. Multidisciplinary Digital Publishing Institute (MDPI)
Life, Vol 11, Iss 1323, p 1323 (2021)
Life; Volume 11; Issue 12; Pages: 1323
Scientia
Life

Disfunció endotelial; Envellliment cel·lular Disfunción endotelial; Envejecimiento celular Endothelial dysfunction; Senescence Endothelial cell dysfunction is the principal cause of several cardiovascular diseases that are increasing in prevalence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87736eb6ee79f253625927dc1b0a84c0
https://pure.eur.nl/en/publications/298f975d-1871-4f67-b8db-5c78effe00d6

Blood stem cells: from beginning to end

Autor: Anna Bigas, Claudia Waskow

Publikováno v: Development. 143:3429-3433

In June 2016, around 200 scientists from all over the world gathered at EMBL headquarters in Heidelberg, Germany to discuss the recent advances in hematopoietic stem cells from three different angles: developmental, adulthood and aging. The meeting,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64975884c41f535b735f68724f432c6
https://doi.org/10.1242/dev.142828

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Autor: Sadaf Khan, Peggy Janich, Hong Jin, Felix Lasitschka, Owen J. Sansom, Athena Georgilis, Torsten Wuestefeld, Lars Zender, Gareth J. Inman, Ana Banito, Tae-Won Kang, Kelly J. Morris, Jesús Gil, Gopuraja Dharmalingam, Dimitris Athineos, Thomas Longerich, Juan Carlos Acosta, Ambrosius P. Snijders, Gloria Pascual, David Capper, Salvador Aznar Benitah, Catrin Pritchard, Thomas L. Carroll, Mindaugas Andrulis, Jennifer P. Morton

Publikováno v: Nature cell biology
U221
Acosta, J C, Banito, A, Wuestefeld, T, Georgilis, A, Janich, P, Morton, J P, Athineos, D, Kang, T-W, Lasitschka, F, Andrulis, M, Pascual, G, Morris, K J, Khan, S, Jin, H, Dharmalingam, G, Snijders, A P, Carroll, T, Capper, D, Pritchard, C, Inman, G J, Longerich, T, Sansom, O J, Benitah, S A, Zender, L & Gil, J 2013, ' A complex secretory program orchestrated by the inflammasome controls paracrine senescence ', Nature Cell Biology, vol. 15, no. 8, pp. 978-90 . https://doi.org/10.1038/ncb2784
Recercat. Dipósit de la Recerca de Catalunya
instname

Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells implement a complex pro-inflammatory response termed the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence, activates immune surveilla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ee10c145bf6bb6727764ccb962a204
http://europepmc.org/articles/PMC3732483