Pembrolizumab With or Without Chemotherapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: Updated Results of the Phase III KEYNOTE-048 Study

Autor: Kevin J. Harrington, Barbara Burtness, Richard Greil, Denis Soulières, Makoto Tahara, Gilberto de Castro, Amanda Psyrri, Irene Brana, Neus Basté, Prakash Neupane, Åse Bratland, Thorsten Fuereder, Brett G.M. Hughes, Ricard Mesia, Nuttapong Ngamphaiboon, Tamara Rordorf, Wan Zamaniah Wan Ishak, Jianxin Lin, Burak Gumuscu, Ramona F. Swaby, Danny Rischin

Publikováno v: Scientia

PURPOSE Pembrolizumab and pembrolizumab-chemotherapy demonstrated efficacy in recurrent/metastatic head and neck squamous cell carcinoma in KEYNOTE-048. Post hoc analysis of long-term efficacy and progression-free survival on next-line therapy (PFS2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb2be241c70ef569c84015a1a2507e2
https://pubmed.ncbi.nlm.nih.gov/36219809

Pembrolizumab Alone or With Chemotherapy for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma in KEYNOTE-048: Subgroup Analysis by Programmed Death Ligand-1 Combined Positive Score

Autor: Barbara Burtness, Danny Rischin, Richard Greil, Denis Soulières, Makoto Tahara, Gilberto de Castro Jr, Amanda Psyrri, Irene Brana, Neus Basté, Prakash Neupane, Åse Bratland, Thorsten Fuereder, Brett G.M. Hughes, Ricard Mesia, Nuttapong Ngamphaiboon, Tamara Rordorf, Wan Zamaniah Wan Ishak, Joy Ge, Ramona F. Swaby, Burak Gumuscu, Kevin Harrington

Publikováno v: Scientia

Quimioteràpia; Carcinoma de cèl·lules escamoses de cap i coll Quimioterapia; Carcinoma de células escamosas de cabeza y cuello Chemotherapy; Head and neck squamous cell carcinoma PURPOSE The phase III KEYNOTE-048 (ClinicalTrials.gov identifier: N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c375dae4601616617fa1f77895fd15e
https://hdl.handle.net/11351/7984

Effects of the Prior Use of Statins on Head and Neck Cancer Risk: A Hospital-Based Case–Control Study

Autor: Constanza Saka-Herrán, Enric Jané-Salas, Antonio Mano-Azul, Aina Torrejón-Moya, Albert Estrugo-Devesa, José López-López

Publikováno v: Pharmaceuticals; Volume 15; Issue 5; Pages: 579
Dipòsit Digital de la UB
Universidad de Barcelona

Mechanisms related to the potential beneficial effects of statins on cancer are mainly related to the inhibition of the mevalonate pathway. The purpose of this study was to assess the association between prior use of statins and the risk of head and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6044836d2590814b285aafa51945e56

VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma

Autor: Miguel A. Pavón, Sonia Zumalave, Myriam Cuadrado, Antonio Abad, Carmen Segrelles, Xosé R. Bustelo, Gloria Pascual, Natalia Fernández-Parejo, María C. García-Macías, Salvador Aznar Benitah, Rogelio González-Sarmiento, Salvatore Fabbiano, Juan P. Rodrigo, Sonia Rodríguez-Fdez, Nazareno González, Mauricio Menacho-Márquez, L. Francisco Lorenzo-Martín, Javier Robles-Valero, Juana M. García-Pedrero, Pablo Lorenzano-Menna, Jesús M. Paramio, Jose M. C. Tubio

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
Nature Communications
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)

© The Author(s) 2020.
Regenerative proliferation capacity and poor differentiation are histological features usually linked to poor prognosis in head and neck squamous cell carcinoma (hnSCC). However, the pathways that regulate them remain ill-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f9e862d0c51daed5c4d0a59fb3a9f7
https://doaj.org/article/383992e6d52c41ef94a9df8bb7b4e08c

Impacte clínic del càlcul de la dosi absorbida en radioteràpia externa mitjançant un nou algorisme basat en la solució de l'equació de Boltzmann

Autor: Muñoz Montplet, Carles

Publikováno v: TDX (Tesis Doctorals en Xarxa)
DUGiDocs – Universitat de Girona
instname
TDR. Tesis Doctorales en Red

The algorithm for calculating absorbed dose in external radiotherapy Acuros XB (AXB), based on the solution of the Boltzmann equation, has shown to achieve a higher level of accuracy than the preceding convolution/superposition algorithm AAA, especia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::218981128c78b46b24122d2d02c5742d
http://hdl.handle.net/10256/21111