The DNA damage response in advanced ovarian cancer: functional analysis combined with machine learning identifies signatures that correlate with chemotherapy sensitivity and patient outcome

Autor: Thomas D. J. Walker, Zahra F. Faraahi, Marcus J. Price, Amy Hawarden, Caitlin A. Waddell, Bryn Russell, Dominique M. Jones, Aiste McCormick, N. Gavrielides, S. Tyagi, Laura C. Woodhouse, Bethany Whalley, Connor Roberts, Emma J. Crosbie, Richard J. Edmondson

Publikováno v: Walker, T D J, Faraahi, Z F, Price, M J, Hawarden, A, Waddell, C A, Russell, B, Jones, D M, McCormick, A, Gavrielides, N, Tyagi, S, Woodhouse, L C, Whalley, B, Roberts, C, Crosbie, E J & Edmondson, R J 2023, ' The DNA damage response in advanced ovarian cancer: functional analysis combined with machine learning identifies signatures that correlate with chemotherapy sensitivity and patient outcome ', British Journal of Cancer . https://doi.org/10.1038/s41416-023-02168-3

Background Ovarian cancers are hallmarked by chromosomal instability. New therapies deliver improved patient outcomes in relevant phenotypes, however therapy resistance and poor long-term survival signal requirements for better patient preselection.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1280700fee921d034c284eae9e468e52
https://doi.org/10.1038/s41416-023-02168-3

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Which outcomes are most important to measure in patients with COVID-19 and how and when should these be measured? Development of an international standard set of outcomes measures for clinical use in patients with COVID-19: a report of the International Consortium for Health Outcomes Measurement (ICHOM) COVID-19 Working Group

Autor: Farhala M Baloch, Alejandro Moscoso Daza, Anne-Marie Russell, Carlos Lumbreras, William Seligman, Ingel K M Demedts, Christina Nielsen, Marcelo P Fleck, Gisele Alsina Nader Bastos, Anju Keetharuth, Luz Sousa Fialho, Douglas C Woodhouse, Nasreen Muhammad, Ingvar I L Ludwig, Ana Londral, Philip Collis, Joel Gagnier, Evan K Wong, Kees Brinkman, Tracy Y. Wang, Nick Sillett, Michaela K Smith, John H. Powers, Eyal Zimlichman, Lucinda E. K. Gabriel, Christine W Owen, Maiara Anschau Floriani

Publikováno v: BMJ Open
BMJ Open, Vol 11, Iss 11 (2021)

ObjectivesThe COVID-19 pandemic has resulted in widespread morbidity and mortality with the consequences expected to be felt for many years. Significant variation exists in the care even of similar patients with COVID-19, including treatment practice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393476ddade4d4281e4a5ea1b99b66b9
https://eprints.whiterose.ac.uk/181144/1/e051065.full.pdf

Feasibility of a Modified Atkins Diet in Glioma Patients During Radiation and Its Effect on Radiation Sensitization

Autor: Rekha Chaudhary, C Woodhouse, T Ward, M Gaskill-Shipley

Publikováno v: Current Oncology
Volume 26
Issue 4
Pages 4889-438

Gliomas are the most dreaded primary brain tumour because of their dismal cure rates. Ketogenic-type diets (kds) are high-fat, low-protein, and low-carbohydrate diets
the modified Atkins diet (mad) is a less-stringent version of a kd that still

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab439b1146d60baaf1676d621a0fee4
https://doi.org/10.3747/co.26.4889