Zobrazeno 1 - 10
of 103
pro vyhledávání: '"C, Wacholtz"'
Publikováno v:
Pharmacoepidemiology and Drug Safety. 20:1009-1013
Registration of randomized clinical trials has become standard practice and is enforced through publication policies and governmental regulations. However, the registration of observational studies remains controversial. In this commentary, we propos
Autor:
Susan Callery-D'Amico, Barbara E. Bierer, David Forster, Carmen E. Aldinger, Holly Fernandez Lynch, Rebecca Li, Mark Barnes, Maeve Luthin, Alla Digilova, Mark Wilenzick, Mary C Wacholtz, Delia Wolf, Liam Boggs, Amy L. Davis, Luann E. Van Campen, Kate Heffernan, Lindsay McNair, Jacquelyn Murphy, Cris Woolston, Jennifer E. Miller
Publikováno v:
Journal of Medical Ethics
A novel Protocol Ethics Tool Kit (‘Ethics Tool Kit’) has been developed by a multi-stakeholder group of the Multi-Regional Clinical Trials Center of Brigham and Women's Hospital and Harvard. The purpose of the Ethics Tool Kit is to facilitate eff
Autor:
Jesse A. Berlin, Mary C. Wacholtz
Publikováno v:
International Journal of Pharmaceutical Medicine. 19:277-284
All information relevant to the care and safety of those who use marketed products should be published, and this is the responsibility of the organisations that carry out clinical research, and pharmaceutical companies in particular. Publication bias
Autor:
Robert A. Lew, W N Roberts, J M Grosflam, Lawren H. Daltroy, Alison J. Partridge, Karin V. Straaton, Anne H. Fossel, S H Stern, Matthew H. Liang, Mary C. Wacholtz, Elizabeth W. Karlson, Arthur F. Kavanaugh, Elizabeth A. Wright
Publikováno v:
Arthritis & Rheumatism. 40:47-56
Objective. To study the relationship of race, socioeconomic status (SES), clinical factors, and psychosocial factors to outcomes in patients with systemic lupus erythematosus (SLE). Methods. A retrospective cohort was assembled, comprising 200 patien
Autor:
Mary C Wacholtz
Publikováno v:
Expert Opinion on Investigational Drugs. 3:973-977
Autor:
M C Wacholtz, P E Lipsky
Publikováno v:
The Journal of Immunology. 150:5338-5349
The changes in [Ca2+]i after mitogen stimulation of individual human peripheral T cells were examined by single cell image analysis to determine the relationship between the Ca2+ signal and functional outcome. Marked heterogeneity in the magnitude of
Publikováno v:
ImmunoMethods. 2:237-244
Prostaglandins are known to influence a variety of functional activities of T cells. Prostaglandins such as PGE2 suppress T-cell function by mechanisms that depend on their capacity to stimulate adenylate cyclase and to increase cyclic AMP (cAMP) lev
Publikováno v:
Cellular Immunology. 147:95-109
One of the metabolic events that results from ligation of the CD3-TCR is an increase in [Ca2+]i. The mechanisms that generate this rise in [Ca2+]i are poorly understood, but involve mobilization of intracellular Ca2+ stores and the movement of extrac
Publikováno v:
The Journal of Immunology. 149:1912-1920
Movement of extracellular Ca2+ is required for the sustained increase in [Ca2+]i necessary for T cell activation. However, the mechanisms mediating mitogen-stimulated Ca2+ movement into T cells have not been completely delineated. To explore the poss
Publikováno v:
Cellular Immunology. 140:81-96
The role of cross-linking the TCR/CD3 complex in the induction of T cell activation was examined using human peripheral blood T cells and the Jurkat leukemic T cell line. IL-2 production was induced from these cells by pulsing them with mAb to CD3 an