Zobrazeno 1 - 10
of 65
pro vyhledávání: '"C, Valcarce"'
Publikováno v:
The Journal Of Prevention of Alzheimer's Disease. :1-6
Increasing evidence supports the role of the Receptor for Advanced Glycation Endproducts (RAGE) in the pathology of Alzheimer’s disease. Azeliragon (TTP488) is an orally bioavailable small molecule inhibitor of RAGE in Phase 3 development as a pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22cb68e736d0e109f37a445a1742f895
https://doi.org/10.14283/jpad.2018.18
https://doi.org/10.14283/jpad.2018.18
Publikováno v:
European Journal of Biochemistry. 260:200-207
Various human body fluids and secretions contain a soluble form of the epidermal growth factor (EGF) precursor. The EGF precursor molecule contains eight EGF modules in addition to EGF itself. Using monoclonal antibodies specific for the EGF modules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9f5014dce70f5570dafc9e070c8117
https://doi.org/10.1046/j.1432-1327.1999.00156.x
https://doi.org/10.1046/j.1432-1327.1999.00156.x
Akademický článek
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Publikováno v:
Journal of Biological Chemistry. 269:26011-26016
The N-terminal epidermal growth factor (EGF)-like module in factor X binds a single Ca2+ with low affinity (Kd = 2.2 mM). When it is linked to the gamma-carboxyglutamic acid (Gla)-containing module, however, the affinity increases approximately 20-fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::254c0580bb102f88d1ce7e12588cc485
https://doi.org/10.1016/s0021-9258(18)47152-9
https://doi.org/10.1016/s0021-9258(18)47152-9
Autor:
Ingemar Björk, Torbjörn Drakenberg, M Selander-Sunnerhagen, C Valcarce, Johan Stenflo, A M Tämlitz
Publikováno v:
Journal of Biological Chemistry. 268:26673-26678
The NH2-terminal epidermal growth factor (EGF)-like module of vitamin K-dependent coagulation factors IX and X and protein C each has one calcium binding site. This module (residues 45-86) from factor X has been isolated previously and found to bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21eac318423349b6e2cd50a37da6ed31
https://doi.org/10.1016/s0021-9258(19)74365-8
https://doi.org/10.1016/s0021-9258(19)74365-8
Publikováno v:
Journal of Biological Chemistry. 266:2453-2458
Factor Xa is the enzymatically active constituent of the prothrombinase complex, which catalyzes the conversion of prothrombin to thrombin. We have isolated fragments, from tryptic digests of factor X, that consists of the gamma-carboxyglutamic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71b10a960251f875ec13dfcbe2a28224
https://doi.org/10.1016/s0021-9258(18)52265-1
https://doi.org/10.1016/s0021-9258(18)52265-1
Publikováno v:
The Journal of biological chemistry. 269(42)
The N-terminal epidermal growth factor (EGF)-like module in factor X binds a single Ca2+ with low affinity (Kd = 2.2 mM). When it is linked to the gamma-carboxyglutamic acid (Gla)-containing module, however, the affinity increases approximately 20-fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf45aac018d01b63744ff021b968be23
https://pubmed.ncbi.nlm.nih.gov/7929311
https://pubmed.ncbi.nlm.nih.gov/7929311
Publikováno v:
The Journal of biological chemistry. 268(35)
The NH2-terminal epidermal growth factor (EGF)-like module of vitamin K-dependent coagulation factors IX and X and protein C each has one calcium binding site. This module (residues 45-86) from factor X has been isolated previously and found to bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c156e2d81b290e1e75edb11aa4333ac6
https://pubmed.ncbi.nlm.nih.gov/8253800
https://pubmed.ncbi.nlm.nih.gov/8253800
Publikováno v:
Current Aspects of Blood Coagulation, Fibrinolysis, and Platelets ISBN: 9784431701231
Blood coagulation results form a series of activations of zymogens of serine proteases by limited proteolytic cleavage. These reactions form what is commonly referred to as a procoagulant cascade. The final zymogen activation is the conversion of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14eab708b9fd3f46939c1d550d10992e
https://doi.org/10.1007/978-4-431-68323-0_1
https://doi.org/10.1007/978-4-431-68323-0_1
Publisher Summary Factors IX and X and protein C are zymogens of vitamin K-dependent serine proteases. The active form of factor IX, factor IXa, is part of the macromolecular complex (factor IXa, factor VIIIa, phospholipid, and calcium ions) that act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b20b2d23dac8652330aeb1e284b762d0
https://doi.org/10.1016/0076-6879(93)22027-d
https://doi.org/10.1016/0076-6879(93)22027-d