Handling informative dropout in longitudinal analysis of health-related quality of life: application of three approaches to data from the esophageal cancer clinical trial PRODIGE 5/ACCORD 17

Autor: B. Cuer, C. Mollevi, A. Anota, E. Charton, B. Juzyna, T. Conroy, C. Touraine

Publikováno v: BMC Medical Research Methodology, Vol 20, Iss 1, Pp 1-13 (2020)

Abstract Background Health-related quality of life (HRQoL) has become a major endpoint to assess the clinical benefit of new therapeutic strategies in oncology clinical trials. Typically, HRQoL outcomes are analyzed using linear mixed models (LMMs).

Externí odkaz: https://doaj.org/article/e8331c8b1e784e619da2d3dfff538ade

Joint modelling with competing risks of dropout for longitudinal analysis of health-related quality of life in cancer clinical trials

Autor: Thierry Conroy, Benjamin Cuer, Sophie Gourgou, Caroline Mollevi, C. Touraine, Beata Juzyna

Publikováno v: Quality of Life Research
Quality of Life Research, Springer Verlag, In press, ⟨10.1007/s11136-021-03040-8⟩
Quality of Life Research, 2022, 31 (5), pp.1359-1370. ⟨10.1007/s11136-021-03040-8⟩

International audience; Purpose: Health-related quality of life (HRQoL) is an important endpoint in cancer clinical trials. Analysis of HRQoL longitudinal data is plagued by missing data, notably due to dropout. Joint models are increasingly receivin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cccb9229e217f2f5e48ff139d9962d0
https://doi.org/10.1007/s11136-021-03040-8

Stratégie de modélisation de la forme fonctionnelle des variables continues dans un modèle de régression en utilisant des splines cubiques restreintes

Autor: L. Gauthier, S. Gourgou, C. Touraine, F. Castan, D. Azria, P. Lemercier, M. Monnier, W. Chaoui, A. Winter

Publikováno v: Revue d'Épidémiologie et de Santé Publique. 71:101805

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::812742c3b3ff9912155c6c70ec72d5c0
https://doi.org/10.1016/j.respe.2023.101805

Abstract P3-14-01: High-dose vitamin D supplementation for the correction of vitamin D insufficiency in patients undergoing adjuvant chemotherapy for breast cancer, a phase II multicenter study

Autor: Véronique D'Hondt, L. Roca, M Metge, A Chapelle, L Rifai, William Jacot, E Legouffe, Gilles Romieu, S Pouderoux, C. Touraine

Publikováno v: Cancer Research. 79:P3-14

Background:Vitamin D (VitD) insufficiency affects most of patients with early breast cancer (EBC). Breast cancer treatment may lead to bone loss, due to premature ovarian failure or direct chemotherapy (CT) cytotoxic effects. These increase the risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3828d08b5c2bf3572943d6d64273ebe
https://doi.org/10.1158/1538-7445.sabcs18-p3-14-01

More accurate cancer-related excess mortality through correcting background mortality for extra variables

Autor: Roch Giorgi, C. Touraine, Nathalie Grafféo

Publikováno v: Statistical Methods in Medical Research
Statistical Methods in Medical Research, 2020, 29 (1), pp.122-136. ⟨10.1177/0962280218823234⟩
Statistical Methods in Medical Research, SAGE Publications, 2020, 29 (1), pp.122-136. ⟨10.1177/0962280218823234⟩

International audience; Relative survival methods used to estimate the excess mortality of cancer patients rely on the background (or expected) mortality derived from general population life tables. These methods are based on splitting the observed m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4bcf1658fed5bb8fd95b0cbc9e4b185
https://doi.org/10.1177/0962280218823234