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Comparative metabolism ofortho-phenylphenol in mouse, rat and man

Autor: S. N. Shabrang, Michael J. Bartels, Kathy A. Brzak, G. K. Sangha, Debra A. McNett, W. R. Christenson, A. L. Mendrala, C. Timchalk

Publikováno v: Xenobiotica. 28:579-594

1. Ortho-phenylphenol (OPP) was well absorbed in the male B6C3F1 mouse, with 84 and 98% of the administered radioactivity recovered in the 0-48-h urine of animals administered a single oral dose of 15 or 800 mg/kg respectively. High absorption and ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904c161c32cc5e7f9ff92d51c3400b06
https://doi.org/10.1080/004982598239335

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Pharmacokinetics of Triclopyr (3,5,6-Trichloro-2-pyridinyloxyacetic Acid) in the Beagle Dog and Rhesus Monkey: Perspective on the Reduced Capacity of Dogs to Excrete This Organic Acid Relative to the Rat, Monkey, and Human

Autor: R. J. Nolan, C. Timchalk

Publikováno v: Toxicology and Applied Pharmacology. 144:268-278

The pharmacokinetics of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) were measured in the beagle dog and rhesus monkey and compared with the kinetics observed in rats and humans. In addition, studies were conducted in anesthetized dogs to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ce3a6f97a933b4802a82069c7df98c
https://doi.org/10.1006/taap.1997.8136

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Comparative Pharmacokinetics of [14C]Metosulam (N-[2,6-Dichloro-3-methylphenyl]-5,7-dimethoxy-1,2,4-triazolo-[1,5a]-pyrimidine-2-sulfonamide) in Rats, Mice and Dogs

Autor: M. D. Dryzga, Nancy L. Freshour, S. L. Eddy, Keith A. Johnson, R. J. Nolan, B. E. Kropscott, C. Timchalk

Publikováno v: Journal of Applied Toxicology. 17:9-21

This study was conducted to provide data on the pharmacokinetics of [14C]metosulam (N-[2,6-dichloro-3-methylphenyl]-5,7-dimethoxy-1,2,4-triazolo-[1,5a]- pyrimidine-2-sulfonamide). Groups of male Sprague-Dawley rats, CD-1 mice and Beagle dogs were giv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bcf60ea91796259e071addd6f32335d
https://doi.org/10.1002/(sici)1099-1263(199701)17:1<9::aid-jat390>3.0.co

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Evaluation of Renal Function in Rhesus Monkeys and Comparison to Beagle Dogs Following Oral Administration of the Organic Acid Triclopyr (3,5,6-Trichloro-2-pyridinyloxyacetic Acid)

Autor: J.F. Quast, C. Timchalk, D. R. Finco

Publikováno v: Toxicological Sciences. 36:47-53

The current study evaluated the effects of triclopyr (3,5, 6-trichloro-2-pyridinyloxyacetic acid) on renal function following oral administration in the beagle dog and rhesus monkey. Male rhesus monkeys were orally administered triclopyr by gavage at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fffc44de027a69f6ef59a14fe8e67c54
https://doi.org/10.1093/toxsci/36.1.47

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Route-Dependent Comparative Metabolism of [14C]Toluene 2,4-Diisocyanate and [14C]Toluene 2,4-Diamine in Fischer 344 Rats

Autor: C. Timchalk, F A Smith, Michael J. Bartels

Publikováno v: Toxicology and Applied Pharmacology. 124:181-190

This study was initiated to evaluate the pharmacokinetics/metabolism of 14C-labeled toluene 2,4-diisocyanate (2,4-[14C]-TDI) following oral and inhalation exposure in the rat. For comparison, the pharmacokinetics/metabolism of toluene 2,4-diamine (2,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84118bcd3d1130fb2d509b54a4a2e91a
https://doi.org/10.1006/taap.1994.1022

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Gas chromatographic/tandem mass spectrometric identification and quantitation of metabolic 4-acetyltoluene-2,4-diamine from the F344 rat

Autor: C. Timchalk, Fred. A. Smith, Michael J. Bartels

Publikováno v: Biological Mass Spectrometry. 22:194-200

2,4-Toluenediamine (TDA) and 2,4-toluenediisocyanate (TDI) are metabolized in the Fischer 344 rat to monoacetyl-2,4-toluenediamine (Ac-TDA) and diacetyl-2,4-toluenediamine (Ac2-TDA). A gas chromatographic/tandem mass spectrometric (GC/MS/MS) method w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d172c0f030cbdb15a3f4324e37b9f43
https://doi.org/10.1002/bms.1200220309

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Determination of the effect of tridiphane on the pharmacokinetics of [14C]-atrazine following oral administration to male fischer 344 rats

Autor: Patrick E. Kastl, C. Timchalk, Patrick W. Langvardt, M. D. Dryzga, D.W. Osborne

Publikováno v: Toxicology. 61:27-40

The absorption, distribution, metabolism and excretion of [ 14 C]-atrazine was studied in male Fischer 344 rats administered a 30 mg [ 14 C]-atrazine/kg of body weight oral dose with or without pretreatment with a non-radiolabeled oral dose of 60 mg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6974739f056e8c8d4d1b32543640edce
https://doi.org/10.1016/0300-483x(90)90004-z

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1,2-Dichloropropane: investigation of the mechanism of mercapturic acid formation in the rat

Autor: Michael J. Bartels, C. Timchalk

Publikováno v: Xenobiotica. 20:1035-1042

1. Three mercapturic acid metabolites were identified in the urine of male and female Fischer 344 rats given 1,2-dichloropropane (DCP) orally (100 mg/kg) or by inhalation exposure (100 ppm, 6 h). 2. These compounds (N-acetyl-S-(2-hydroxypropyl)-L-cys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf405cf086c3e4031350c64cf3396ff
https://doi.org/10.3109/00498259009046824

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