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Akademický článek

mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity

Autor: Joseph A. Waldron, David C. Tack, Laura E. Ritchey, Sarah L. Gillen, Ania Wilczynska, Ernest Turro, Philip C. Bevilacqua, Sarah M. Assmann, Martin Bushell, John Le Quesne

Publikováno v: Genome Biology, Vol 20, Iss 1, Pp 1-23 (2019)

Abstract Background The RNA helicase eIF4A1 is a key component of the translation initiation machinery and is required for the translation of many pro-oncogenic mRNAs. There is increasing interest in targeting eIF4A1 therapeutically in cancer, thus u

Externí odkaz: https://doaj.org/article/d794b67464054d98b003db09e6fd419c

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Akademický článek

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eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation

Autor: Tobias Schmidt, Adrianna Dabrowska, Joseph A Waldron, Kelly Hodge, Grigorios Koulouras, Mads Gabrielsen, June Munro, David C Tack, Gemma Harris, Ewan McGhee, David Scott, Leo M Carlin, Danny Huang, John Le Quesne, Sara Zanivan, Ania Wilczynska, Martin Bushell

Publikováno v: Nucleic acids research, vol 51, iss 4

Altered eIF4A1 activity promotes translation of highly structured, eIF4A1-dependent oncogene mRNAs at root of oncogenic translational programmes. It remains unclear how these mRNAs recruit and activate eIF4A1 unwinding specifically to facilitate thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd30af1f43661cd10c2521513853ddd
https://escholarship.org/uc/item/6xx8242v

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Purine-rich RNA sequences in the 5’UTR site-specifically regulate eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation

Autor: Tobias Schmidt, Adrianna Dabrowska, Joseph A. Waldron, Kelly Hodge, Grigorios Koulouras, Mads Gabrielsen, June Munro, David C. Tack, Gemma Harris, Ewan McGhee, David Scott, Leo M. Carlin, Danny Huang, John Le Quesne, Sara Zanivan, Ania Wilczynska, Martin Bushell

Oncogenic translational programmes underpin cancer development and are often driven by dysregulation of oncogenic signalling pathways that converge on the eukaryotic translation initiation (eIF) 4F complex. Altered eIF4F activity promotes translation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f236a5f2def6eb392d4e9a3432d9fb4a
https://doi.org/10.1101/2022.08.08.503179

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Transcriptome-wide probing reveals RNA thermometers that regulate translation of glycerol permease genes inBacillus subtilis

Autor: Elizabeth A Jolley, Helen Yakhnin, David C Tack, Paul Babitzke, Philip C Bevilacqua

Publikováno v: RNA. :rna.079652.123

RNA structure regulates bacterial gene expression by several distinct mechanisms via environmental and cellular stimuli, one of which is temperature. While some genome-wide studies have focused on heat shock treatments and the subsequent transcriptom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::570a6b962a8961bda465f645961083f8
https://doi.org/10.1261/rna.079652.123

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Structure-seq2 probing of RNA structure upon amino acid starvation reveals both known and novel RNA switches in Bacillus subtilis

Autor: Helen Yakhnin, Laura E. Ritchey, David C. Tack, Paul Babitzke, Philip C. Bevilacqua, Elizabeth A. Jolley, Sarah M. Assmann

Publikováno v: RNA. 26:1431-1447

RNA structure influences numerous processes in all organisms. In bacteria, these processes include transcription termination and attenuation, small RNA and protein binding, translation initiation, and mRNA stability, and can be regulated via metaboli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dcb2c834053a6d68262b16a7fd3aac9
https://doi.org/10.1261/rna.075986.120

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Therapeutic efficacy of the root tubers of Aconitum heterophyllum and its substitute Cyperus rotundus in the amelioration of pylorus ligation induced ulcerogenic and oxidative damage in rats

Autor: Young Ock Kim, P.B. Benil, J.-C. Tack, Abdullah Al-Ansari, R. Lekshmi, Hak-Jae Kim, R. Sreelakshmi, Ahmad Al-Farhan, R. Rajakrishnan, S.W. Na

Publikováno v: Saudi Journal of Biological Sciences, Vol 27, Iss 4, Pp 1124-1129 (2020)
Saudi Journal of Biological Sciences

The phenomenal increase in the demand of herbal drugs, leads to over exploitation of medicinal plants which ultimately resulted in the scarcity and endangerment of many valuable plant species. On observing the difficulties in procuring genuine herbal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc1d032406da47a52422bdd9a68db67
http://www.sciencedirect.com/science/article/pii/S1319562X19303250

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Green synthesis and characterization of gold nanoparticles using endophytic fungi Fusarium solani and its in-vitro anticancer and biomedical applications

Autor: Asad Syed, Hak-Jae Kim, Hind A. AL-Shwaiman, Paul Agastian, Prince Clarance, J.-C. Tack, Ben Luvankar, Manal M. Al Khulaifi, Abdallah M. Elgorban, Jerin Sales, Ameer Khusro

Publikováno v: Saudi Journal of Biological Sciences, Vol 27, Iss 2, Pp 706-712 (2020)
Saudi Journal of Biological Sciences

The present study aimed to explore the anticancer potentials of the gold nanoparticles (NPs) obtained by green synthesis method using an endophytic strain Fusarium solani ATLOY – 8 has been isolated from the plant Chonemorpha fragrans. The formatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57eccb5b25f25214dd16b9eb754ee9cc
https://doi.org/10.1016/j.sjbs.2019.12.026

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Tissue-specific changes in the RNA structurome mediate salinity response in Arabidopsis

Autor: Sarah M. Assmann, David C. Tack, Zhao Su, Yunqing Yu, Philip C. Bevilacqua

Publikováno v: RNA. 26:492-511

Little is known concerning the effects of abiotic factors on in vivo RNA structures. We applied Structure-seq to assess the in vivo mRNA structuromes of Arabidopsis thaliana under salinity stress, which negatively impacts agriculture. Structure-seq u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1276165cd4880e0786e17030f7a75620
https://doi.org/10.1261/rna.072850.119

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