Výsledky vyhledávání - "C, Sudandiradoss"

Akademický článek

Discovery of andrographolide hit analog as a potent cyclooxygenase-2 inhibitor through consensus MD-simulation, electrostatic potential energy simulation and ligand efficiency metrics

Autor: Priyanka Jain, Jitendra Satija, C. Sudandiradoss

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)

Abstract Cyclooxygenase-2 (COX-2) is the key enzyme responsible for the conversion of arachidonic acid to prostaglandins that display pro-inflammatory properties and thus, it is a potential target protein to develop anti-inflammatory drugs. In this s

Externí odkaz: https://doaj.org/article/863729de5da34672982582f45e7e87a9

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Structural localization of pathogenic mutations in the central nucleotide-binding domain (NBD) of nucleotide-binding oligomerization domain-2 (NOD2) protein and their inference in inflammatory disorders

Autor: Sayani Mukherjee, Sulagno Chakraborty, P. Raghuraman, Sriroopreddy Ramireddy, J. Sreeshma, C. Sudandiradoss

Publikováno v: Nucleosides, Nucleotides & Nucleic Acids. 40:1198-1219

The human NBD domain which is centrally located in the NOD2 protein displays an essential role in oligomerization and initiates the immune response via CARD-RIPK2 interaction. The mutations associated with the NBD domain have been largely implicated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a77205573e3cbb36f0c1ba8679bd8a5
https://doi.org/10.1080/15257770.2021.1986719

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Akademický článek

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Transcriptomic analysis of castration, chemo-resistant and metastatic prostate cancer elucidates complex genetic crosstalk leading to disease progression

Autor: C. Sudandiradoss, Sayani Mukherjee

Publikováno v: Functional & Integrative Genomics. 21:451-472

Prostate adenocarcinoma, with its rising numbers and high fatality rate, is a daunting healthcare challenge to clinicians and researchers alike. The mainstay of our meta-analysis was to decipher differentially expressed genes (DEGs), their correspond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7385662061f3206a132a06c8a92bc91d
https://doi.org/10.1007/s10142-021-00789-6

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Akademický článek

Evaluation of peptide designing strategy against subunit reassociation in mucin 1: A steered molecular dynamics approach.

Autor: J Lesitha Jeeva Kumari, R Jesu Jaya Sudan, C Sudandiradoss

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0183041 (2017)

Subunit reassociation in mucin 1, a breast cancer tumor marker, is reported as one of the critical factors for its cytoplasmic activation. Inhibition of its heterodimeric association would therefore result in loss of its function and alter disease pr

Externí odkaz: https://doaj.org/article/66882ea9ee0046838cf3ab36427e3e8a

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Identification of metal binding motifs in protein frameworks to develop novel remediation strategies for Hg2+ and Cr(VI)

Autor: C. Sudandiradoss, J. Sreeshma

Publikováno v: BioMetals. 34:621-638

Amino acid sequences in metal-binding proteins with chelating properties offer exciting applications in biotechnology and medical research. To enhance their application in bioremediation studies, we explicitly aimed to identify specific metal-binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d256d8519d644f2f0cd5e789c794146
https://doi.org/10.1007/s10534-021-00300-5

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Delineating the folding perturbations and molecular mechanisms of Thr-Ala 642 mutation in Rab-GTPase activating protein Akt substrate of 160kDa and its impact on the aetiology of diabetes

Autor: C. Sudandiradoss, P. Raghuraman, Utkarsh Nagpal, D Kamalesh, Sriroopreddy Ramireddy

Publikováno v: Journal of Biomolecular Structure and Dynamics. 39:409-420

Diabetes Mellitus is a complex metabolic disorder with one of the highest prevalence rates in the world. The present study probes into the Thr-Ala 642 mutation of Akt substrate of 160 kDa (AS160) which has been implicated in diabetes by the dysregula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01e33d15871fc613217975f582d796c
https://doi.org/10.1080/07391102.2020.1726814

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Akademický článek

Ab initio coordination chemistry for nickel chelation motifs.

Autor: R Jesu Jaya Sudan, J Lesitha Jeeva Kumari, C Sudandiradoss

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0126787 (2015)

Chelation therapy is one of the most appreciated methods in the treatment of metal induced disease predisposition. Coordination chemistry provides a way to understand metal association in biological structures. In this work we have implemented coordi

Externí odkaz: https://doaj.org/article/39895128a31d4c1fbacdbbd467b2e83a

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Streptozocin; a GLUT2 binding drug, interacts with human serum albumin at loci h6DOM3-h7DOM3

Autor: Amogh S. Deshpande, Ayesha Noor, Sriroopreddy Ramireddy, C. Sudandiradoss, Priyankar Sen

Publikováno v: International Journal of Biological Macromolecules. 128:923-933

Streptozocin (STZ) is a broad range antibiotic, highly genotoxic, antineoplastic and hyperglycemic. HSA is the most abundant protein in physiology and it binds to almost all exogenic and endogenic ligands, including drugs. STZ-induced fluorescence qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::caf3e3363f5004a2cf7510667ca93736
https://doi.org/10.1016/j.ijbiomac.2019.01.217

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