Zobrazeno 1 - 10
of 824
pro vyhledávání: '"C, Straub"'
Autor:
Fabliha A. Chowdhury, Malini Sharma, Desiree Schafer, Seyed M. Nouraie, Mark T. Gladwin, Adam C. Straub, Katherine C. Wood
Publikováno v:
Blood Advances, Vol 8, Iss 23, Pp 6098-6103 (2024)
Externí odkaz:
https://doaj.org/article/c9d4be83ff01468c92c0a2135d327555
Autor:
Tracey D. Myers, Yizhi Li, Stefanie Taiclet, Paulina Cabada-Aguirre, Emily Kuti, Kaitlin McClure, Christopher Blanchard, Marta Wolosowicz, Gregg E. Homanics, Adam C. Straub, Stephen D. Meriney, Michael J. Palladino
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Triosephosphate isomerase deficiency (TPI Df) is a rare multisystem disorder with severe neuromuscular symptoms which arises exclusively from mutations within the TPI1 gene. Studies of TPI Df have been limited due to the absence of mammalian
Externí odkaz:
https://doaj.org/article/cadf9011a35d4760a00e26990a31124a
Autor:
Shuai Yuan, Adam C Straub
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0303472 (2024)
Plasmid transfection in cells is widely employed to express exogenous proteins, offering valuable mechanistic insight into their function(s). However, plasmid transfection efficiency in primary vascular endothelial cells (ECs) and smooth muscle cells
Externí odkaz:
https://doaj.org/article/355f42022c5c4e6bbf85b89551e87b39
Autor:
Fabliha A. Chowdhury, Nicole Colussi, Malini Sharma, Katherine C. Wood, Julia Z. Xu, Bruce A. Freeman, Francisco J. Schopfer, Adam C. Straub
Publikováno v:
Redox Biology, Vol 68, Iss , Pp 102941- (2023)
Sickle cell disease (SCD) is a hereditary hematological disease with high morbidity and mortality rates worldwide. Despite being monogenic, SCD patients display a plethora of disease-associated complications including anemia, oxidative stress, steril
Externí odkaz:
https://doaj.org/article/e1bc2e80353f4d6091066d02a5726433
Autor:
Evan R. DeVallance, Heidi M. Schmidt, Madison Seman, Sara E. Lewis, Katherine C. Wood, Schuyler D. Vickers, Scott A. Hahn, Murugesan Velayutham, Emily A. Hileman, Dario A. Vitturi, Roberta Leonardi, Adam C. Straub, Eric E. Kelley
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102866- (2023)
We recently reported a previously unknown salutary role for xanthine oxidoreductase (XOR) in intravascular heme overload whereby hepatocellular export of XOR to the circulation was identified as a seminal step in affording protection. However, the ce
Externí odkaz:
https://doaj.org/article/87ca64a023a542648045412108a3db24
Autor:
Heidi M. Schmidt, Evan R. DeVallance, Sara E. Lewis, Katherine C. Wood, Gowtham K. Annarapu, Mara Carreño, Scott A. Hahn, Madison Seman, Brooke A. Maxwell, Emily A. Hileman, Julia Z. Xu, Murugesan Velayutham, Werner J. Geldenhuys, Dario A. Vitturi, Sruti Shiva, Eric E. Kelley, Adam C. Straub
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102636- (2023)
Xanthine oxidase (XO) catalyzes the catabolism of hypoxanthine to xanthine and xanthine to uric acid, generating oxidants as a byproduct. Importantly, XO activity is elevated in numerous hemolytic conditions including sickle cell disease (SCD); howev
Externí odkaz:
https://doaj.org/article/fc1d13f5ed7a4f76bf1f12017427f9c4
Publikováno v:
Chemistry, Vol 4, Iss 3, Pp 647-654 (2022)
A new synthesis strategy towards gold-coated silica nanoparticles is presented. The method provides an efficient, reliable and facile-coating process of well-defined star-shaped shell structures, characterized by UV-Vis, TEM, PXRD, DLS and zeta-poten
Externí odkaz:
https://doaj.org/article/f7f0d7d6b15845f5bd7dff407f5852e5
Autor:
Marta Bueno, Jazmin Calyeca, Timur Khaliullin, Megan P. Miller, Diana Alvarez, Lorena Rosas, Judith Brands, Christian Baker, Amro Nasser, Stephanie Shulkowski, August Mathien, Nneoma Uzoukwu, John Sembrat, Brenton G. Mays, Kaitlin Fiedler, Scott A. Hahn, Sonia R. Salvatore, Francisco J. Schopfer, Mauricio Rojas, Peter Sandner, Adam C. Straub, Ana L. Mora
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
Type II alveolar epithelial cell (AECII) redox imbalance contributes to the pathogenesis of idiopathic pulmonary fibrosis (IPF), a deadly disease with limited treatment options. Here, we show that expression of membrane-bound cytochrome B5 reductase
Externí odkaz:
https://doaj.org/article/c430eef5b8e94876abbd6d496306422d
Autor:
Scott M Emrich, Ryan E Yoast, Xuexin Zhang, Adam J Fike, Yin-Hu Wang, Kristen N Bricker, Anthony Y Tao, Ping Xin, Vonn Walter, Martin T Johnson, Trayambak Pathak, Adam C Straub, Stefan Feske, Ziaur SM Rahman, Mohamed Trebak
Publikováno v:
eLife, Vol 12 (2023)
The essential role of store-operated Ca2+ entry (SOCE) through Ca2+ release-activated Ca2+ (CRAC) channels in T cells is well established. In contrast, the contribution of individual Orai isoforms to SOCE and their downstream signaling functions in B
Externí odkaz:
https://doaj.org/article/5b4624a722da497c9f2661a9b380baec
Autor:
Nolan T. Carew, Heidi M. Schmidt, Shuai Yuan, Joseph C. Galley, Robert Hall, Helene M. Altmann, Scott A. Hahn, Megan P. Miller, Katherine C. Wood, Bethann Gabris, Margaret C. Stapleton, Sean Hartwick, Marco Fazzari, Yijen L. Wu, Mohamed Trebak, Brett A. Kaufman, Charles F. McTiernan, Francisco J. Schopfer, Placido Navas, Patrick H. Thibodeau, Dennis M. McNamara, Guy Salama, Adam C. Straub
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
Sudden cardiac death (SCD) in patients with heart failure (HF) is allied with an imbalance in reduction and oxidation (redox) signaling in cardiomyocytes; however, the basic pathways and mechanisms governing redox homeostasis in cardiomyocytes are no
Externí odkaz:
https://doaj.org/article/347f7b78e498476bb1cd8f897c890698