Zobrazeno 1 - 10
of 597
pro vyhledávání: '"C, Spray"'
Autor:
Qu Xing, Antonio Cibelli, Greta Luyuan Yang, Preeti Dohare, Qing-Hua Li, Eliana Scemes, Fang-Xia Guan, David C. Spray
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-16 (2024)
Abstract Background The channel-forming protein Pannexin1 (Panx1) has been implicated in both human studies and animal models of chronic pain, but the underlying mechanisms remain incompletely understood. Methods Wild-type (WT, n = 24), global Panx1
Externí odkaz:
https://doaj.org/article/d51e0c3456d9496184d8ab31b7ea130d
Autor:
Antonio Cibelli, David Ballesteros-Gomez, Sean McCutcheon, Greta L. Yang, Ashley Bispo, Michael Krawchuk, Giselle Piedra, David C. Spray
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110069- (2024)
Summary: Astrocyte endfeet enwrap brain vasculature, forming a boundary for perivascular glymphatic flow of fluid and solutes along and across the astrocyte endfeet into the brain parenchyma. We evaluated astrocyte sensitivity to shear stress generat
Externí odkaz:
https://doaj.org/article/e785a16960634e1ab01957d07650810f
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0295710 (2023)
Pannexins are ubiquitously expressed in human and mouse tissues. Pannexin 1 (Panx1), the most thoroughly characterized member of this family, forms plasmalemmal membrane channels permeable to relatively large molecules, such as ATP. Although human an
Externí odkaz:
https://doaj.org/article/ecc452b2ac014e4ebd47f6fa42845f4b
Autor:
Antonio Cibelli, Randy Stout, Aline Timmermann, Laura de Menezes, Peng Guo, Karen Maass, Gerald Seifert, Christian Steinhäuser, David C. Spray, Eliana Scemes
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The neurovascular unit (NVU) consists of cells intrinsic to the vessel wall, the endothelial cells and pericytes, and astrocyte endfeet that surround the vessel but are separated from it by basement membrane. Endothelial cells are primarily
Externí odkaz:
https://doaj.org/article/ad79486a15d049f9b8d3ca38056578a7
Autor:
Ciaran Murphy-Royal, April D. Johnston, Andrew K. J. Boyce, Blanca Diaz-Castro, Adam Institoris, Govind Peringod, Oliver Zhang, Randy F. Stout, David C. Spray, Roger J. Thompson, Baljit S. Khakh, Jaideep S. Bains, Grant R. Gordon
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Enduring changes in synaptic efficacy are highly sensitive to stress. Here, the authors show that astrocytic delivery of metabolites has an important role in the stress-mediated impairment of synaptic plasticity.
Externí odkaz:
https://doaj.org/article/a10e4cb6fa8941679643d05fade21f65
Autor:
Ross Luu, Silvana Valdebenito, Eliana Scemes, Antonio Cibelli, David C. Spray, Maximiliano Rovegno, Juan Tichauer, Andrea Cottignies-Calamarte, Arielle Rosenberg, Calude Capron, Sandrine Belouzard, Jean Dubuisson, Djillali Annane, Geoffroy Lorin de la Grandmaison, Elisabeth Cramer-Bordé, Morgane Bomsel, Eliseo Eugenin
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103478- (2021)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly rampaged worldwide, causing a pandemic of coronavirus disease (COVID -19), but the biology of SARS-CoV-2 remains under investigation. We demonstrate that both SARS-CoV-2 sp
Externí odkaz:
https://doaj.org/article/90aa3a5ba1df4dd5a1cd73c53a82493c
Publikováno v:
Cells, Vol 11, Iss 20, p 3219 (2022)
Pannexin1 (Panx1) is expressed in both neurons and glia where it forms ATP-permeable channels that are activated under pathological conditions such as epilepsy, migraine, inflammation, and ischemia. Membrane lipid composition affects proper distribut
Externí odkaz:
https://doaj.org/article/87f5ef994f404b08a18c6f6e566a50c4
Autor:
Antonio Cibelli, Sandra Veronica Lopez-Quintero, Sean Mccutcheon, Eliana Scemes, David C. Spray, Randy F. Stout, Sylvia O. Suadicani, Mia M. Thi, Marcia Urban-Maldonado
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
We transduced mouse cortical astrocytes cultured from four litters of embryonic wildtype (WT) and connexin43 (Cx43) null mouse pups with lentiviral vector encoding hTERT and measured expression of astrocyte-specific markers up to passage 10 (p10). Th
Externí odkaz:
https://doaj.org/article/8040b483b6574b3d9e818fbff5a9e81b
Autor:
Lindice M. Nisimura, Laura L. Coelho, Tatiana G. de Melo, Paloma de Carvalho Vieira, Pedro H. Victorino, Luciana R. Garzoni, David C. Spray, Dumitru A. Iacobas, Sanda Iacobas, Herbert B. Tanowitz, Daniel Adesse
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Chagas disease is responsible for more than 10,000 deaths per year and about 6 to 7 million infected people worldwide. In its chronic stage, patients can develop mega-colon, mega-esophagus, and cardiomyopathy. Differences in clinical outcomes may be
Externí odkaz:
https://doaj.org/article/8d5c0668d6294b36980734a44734049d
Autor:
David C. Spray, Sean McCutcheon
Supplementary Data from Glioblastoma–Astrocyte Connexin 43 Gap Junctions Promote Tumor Invasion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1261dc3562af3f7fc5add2ba8d09f968
https://doi.org/10.1158/1541-7786.22528080
https://doi.org/10.1158/1541-7786.22528080
