Výsledky vyhledávání - "C, Schwanstecher"

Synthesis and evaluation of a glibenclamide glucose-conjugate: a potential new lead compound for substituted glibenclamide derivatives as islet imaging agents

Autor: M. Schwanstecher, C. Schwanstecher, A. Korobeynikov, E. Schirrmacher, H. H. Klein, Sandra Ueberberg, Stephan Schneider, W. Schechinger

Publikováno v: Regulatory peptides. 139(1-3)

The search for novel SUR1-ligands originates from the idea to influence the in vivo behaviour by adding new structural moieties to the glibenclamide structure while preserving its binding affinity. Important application of novel conjugates might be t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081710a937f7edf3ebbb7836bc96cb04
https://pubmed.ncbi.nlm.nih.gov/17222470

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In vitro and in vivo evaluation of novel glibenclamide derivatives as imaging agents for the non-invasive assessment of the pancreatic islet cell mass in animals and humans

Publikováno v: Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 113(7)

Pancreatic islet cell mass (PICM) is a major determinant of the insulin secretory capacity in humans. Currently, the only method for accurate assessment of the PICM is an autopsy study. Thus, development of a technique allowing the non-invasive quant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23f1819c9125848658d7d232302d6f6
https://pubmed.ncbi.nlm.nih.gov/16025400

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ATP4- mediates closure of pancreatic beta-cell ATP-sensitive potassium channels by interaction with 1 of 4 identical sites

Autor: C Schwanstecher, M Schwanstecher, E Markworth

Publikováno v: Diabetes. 49(9)

In pancreatic beta-cells, cytosolic [ATP(4-)] critically controls insulin secretion via inhibition of ATP-sensitive potassium (KATP) channels. These channels are heteromultimers composed with a 4:4 stoichiometry of an inwardly rectifying K+ channel s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c86b4570703bce0c0378e3362629fd5
https://pubmed.ncbi.nlm.nih.gov/10969823

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Interaction of N-benzoyl-D-phenylalanine and related compounds with the sulphonylurea receptor of beta-cells

Autor: C, Schwanstecher, M, Meyer, M, Schwanstecher, U, Panten

Publikováno v: British journal of pharmacology. 123(6)

1. The structure activity relationships for the insulin secretagogues N-benzoyl-D-phenylalanine (NBDP) and related compounds were examined at the sulphonylurea receptor level by use of cultured HIT-T15 and mouse pancreatic beta-cells. The affinities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30b2fcc66cb8742c4f72fd603329bb30
https://pubmed.ncbi.nlm.nih.gov/9559882

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Cytosolic nucleotides enhance the tolbutamide sensitivity of the ATP-dependent K+ channel in mouse pancreatic B cells by their combined actions at inhibitory and stimulatory receptors

Autor: C, Schwanstecher, C, Dickel, U, Panten

Publikováno v: Molecular pharmacology. 41(3)

In the plasma membrane of pancreatic B cells, a K+ channel (K-ATP channel) has been identified that is regulated by cytoplasmic nucleotides. This channel is inhibited by sulfonylureas. We have previously shown that the potency of tolbutamide is much

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c9310bac5ceb5ecc70d475b1e74e3ed7
https://pubmed.ncbi.nlm.nih.gov/1545776

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