Zobrazeno 1 - 10
of 201
pro vyhledávání: '"C, Schudt"'
Autor:
M-J, Sanz, J, Cortijo, M A, Taha, M, Cerdá-Nicolás, E, Schatton, B, Burgbacher, J, Klar, H, Tenor, C, Schudt, A C, Issekutz, A, Hatzelmann, E J, Morcillo
Publikováno v:
British journal of pharmacology. 152(4)
The present study addressed the effects of the investigational PDE4 inhibitor roflumilast on leukocyte-endothelial cell interactions and endothelial permeability in vivo and in vitro.In vivo, intravital video-microscopy was used to determine effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e16d545bfc172b84d2edc97420323c78
https://pubmed.ncbi.nlm.nih.gov/17704822
https://pubmed.ncbi.nlm.nih.gov/17704822
Autor:
A, Hatzelmann, C, Schudt
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 297(1)
From a series of benzamide derivatives, roflumilast (3-cyclo-propylmethoxy-4-difluoromethoxy-N-[3,5-di-chloropyrid-4-yl]-benzamide) was identified as a potent and selective PDE4 inhibitor. It inhibits PDE4 activity from human neutrophils with an IC(5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::062550e2b01bb0af66bc492e03b15ec6
https://pubmed.ncbi.nlm.nih.gov/11259554
https://pubmed.ncbi.nlm.nih.gov/11259554
Autor:
R T, Schermuly, A, Roehl, N, Weissmann, H A, Ghofrani, C, Schudt, H, Tenor, F, Grimminger, W, Seeger, D, Walmrath
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 292(2)
Aerosolized prostacyclin (PGI(2)) has been suggested for selective pulmonary vasodilation, but its effect rapidly levels off after termination of nebulization. Stabilization of the second-messenger cAMP by phosphodiesterase (PDE) inhibition may offer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e7cdf21e88abec92045e09d74cd78149
https://pubmed.ncbi.nlm.nih.gov/10640287
https://pubmed.ncbi.nlm.nih.gov/10640287
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 283(3)
Exposure of perfused rat lungs to lipopolysaccharides (LPS) causes induction of cyclooxygenase-2 followed by thromboxane (TX)-mediated bronchoconstriction (BC). Recently, phosphodiesterase (PDE) inhibitors have received much interest because they not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2420052955310a53f74da80abbd85e1f
https://pubmed.ncbi.nlm.nih.gov/9400021
https://pubmed.ncbi.nlm.nih.gov/9400021
Publikováno v:
British journal of pharmacology. 121(2)
1. During in vitro culture in 10% human AB serum, human peripheral blood monocytes acquire a macrophage-like phenotype. The underlying differentiation was characterized by increased activities of the macrophage marker enzymes unspecific esterase (NaF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d4ef9ecf75987e2a4724954dc9fbe3f
https://pubmed.ncbi.nlm.nih.gov/9154331
https://pubmed.ncbi.nlm.nih.gov/9154331
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(1)
Injection of the T cell mitogens concanavalin A (Con A) into nonsensitized or of staphylococcal enterotoxin B (SEB) into D-galactosamine (GalN)-sensitized mice is known to cause fulminant liver failure via a cytokine response syndrome with tumor necr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b184fd6dc3b1e185f0a92ebd0c7fe238
https://pubmed.ncbi.nlm.nih.gov/8996181
https://pubmed.ncbi.nlm.nih.gov/8996181
Publikováno v:
European journal of pharmacology. 298(3)
The present study was designed to characterize the effects of unselective and isoenzyme-selective phosphodiesterase inhibitors on airway mucus secretion. The isolated rat trachea was incubated in a modified Ussing chamber. Mucus macromolecules were m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a457ae976894aeabe4eda958838fefd
https://pubmed.ncbi.nlm.nih.gov/8846825
https://pubmed.ncbi.nlm.nih.gov/8846825
Publikováno v:
Wiener medizinische Wochenschrift (1946). 145(17-18)
An increased activity of the cAMP-degrading enzyme phosphodiesterase (PDE) has been observed in peripheral leukocytes from atopic patients. We studied 9 patients with seasonal allergic rhinoconjunctivitis and 9 controls during (summer) and out of sym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f4982ce29bbec82007180dbd0b6aaaa
https://pubmed.ncbi.nlm.nih.gov/8588365
https://pubmed.ncbi.nlm.nih.gov/8588365
Publikováno v:
The American journal of physiology. 266(5 Pt 1)
The effects of the nonselective phosphodiesterase (PDE) inhibitor 3-isobutyl-1-methylxanthine (IBMX) and the selective PDE inhibitors motapizone (type III), rolipram (type IV), zardaverine (type III/IV), and zaprinast (type V and I) on prostaglandin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bcbc1c61b4af4c17170e95afd7b9664
https://pubmed.ncbi.nlm.nih.gov/7515580
https://pubmed.ncbi.nlm.nih.gov/7515580