Zobrazeno 1 - 10
of 343
pro vyhledávání: '"C, Samuelson"'
Autor:
Eun-Kyung Choi, Thekkelnaycke M. Rajendiran, Tanu Soni, Jin-Ho Park, Luisa Aring, Chithra K. Muraleedharan, Vicky Garcia-Hernandez, Nobuhiko Kamada, Linda C. Samuelson, Asma Nusrat, Shigeki Iwase, Young Ah Seo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The metal ion transporter SLC39A8 is associated with physiological traits and diseases, including blood manganese (Mn) levels and inflammatory bowel diseases (IBD). The mechanisms by which SLC39A8 controls Mn homeostasis and epithelial integ
Externí odkaz:
https://doaj.org/article/01f9780565ff47d7966f8adea0d65f6b
Autor:
Minyong Chen, Diego M. Assis, Matthieu Benet, Colleen M. McClung, Elizabeth A. Gordon, Shourjo Ghose, Steven J. Dupard, Matthew Willetts, Christopher H. Taron, James C. Samuelson
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Comparative site-specific N-glycoproteome analysis of tumorigenic and non-tumorigenic colon cancer cells provides a pool of potential N-glycosylation related cancer biomarkers and insights into the mannose-6-phosphate pathway in cancer.
Externí odkaz:
https://doaj.org/article/42fc7757cb6f4c4ab40393030e26e664
Autor:
Nobukatsu Horita, Theresa M. Keeley, Elise S. Hibdon, Elizabeth Delgado, Daniel Lafkas, Christian W. Siebel, Linda C. Samuelson
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 275-287 (2022)
Background & Aims: Notch pathway signaling maintains gastric epithelial cell homeostasis by regulating stem cell proliferation and differentiation. We previously identified NOTCH1 and NOTCH2 as the key Notch receptors controlling gastric stem cell fu
Externí odkaz:
https://doaj.org/article/c9c7c90acdba43d3b35b4515ca88e447
Autor:
Breanna J. Sheahan, Ally N. Freeman, Theresa M. Keeley, Linda C. Samuelson, Jatin Roper, Stephanie Hasapis, Chang-Lung Lee, Christopher M. Dekaney
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 119-140 (2021)
Background & Aims: aISCs (aISCs) are sensitive to acute insults including chemotherapy and irradiation. Regeneration after aISC depletion has primarily been explored in irradiation (IR). However, the cellular origin of epithelial regeneration after d
Externí odkaz:
https://doaj.org/article/1fdc8017627a4936aaa507c1c7059457
Autor:
Natacha Bohin, Kevin P. McGowan, Theresa M. Keeley, Elizabeth A. Carlson, Kelley S. Yan, Linda C. Samuelson
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 797-810 (2020)
Background & Aims: Intestinal crypts have a remarkable capacity to regenerate after injury from loss of crypt base columnar (CBC) stem cells. After injury, facultative stem cells (FSCs) are activated to replenish the epithelium and replace lost CBCs.
Externí odkaz:
https://doaj.org/article/5de53985d03c4f63b42bc31b9a96944e
Autor:
Elise S. Hibdon, Nataliya Razumilava, Theresa M. Keeley, Gabriela Wong, Sumeet Solanki, Yatrik M. Shah, Linda C. Samuelson
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 7, Pp 702-712 (2019)
Notch pathway signaling is known to promote gastric stem cell proliferation, and constitutive pathway activation induces gastric tumors via mTORC1 activation in mouse genetic models. The purpose of this study was to determine whether human gastric ad
Externí odkaz:
https://doaj.org/article/d662b33e3cc24f239c347489e3a6e4e3
Publikováno v:
Stem Cell Reports, Vol 11, Iss 6, Pp 1337-1346 (2018)
Summary: With the tamoxifen-inducible CreERT2 system, genetic recombination can be temporally controlled in a cell-type-specific manner in intact animals, permitting dissection of the molecular underpinnings of mammalian physiology. Here we present a
Externí odkaz:
https://doaj.org/article/0cf764cade604e04ab24b63596cf0e25
Autor:
Wei Ye, Hidehiko Takabayashi, Yitian Yang, Maria Mao, Elise S. Hibdon, Linda C. Samuelson, Kathryn A. Eaton, Andrea Todisco
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 523-538 (2018)
Background & Aims: Gastric Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) cells exert important functions during injury and homeostasis. Bone morphogenetic protein (BMP) signaling regulates gastric inflammation and epithelial home
Externí odkaz:
https://doaj.org/article/fe0190a8d65547f2b4ff0a3ad63da261
Autor:
Li Liu, Jiri Veis, Wolfgang Reiter, Edwin Motari, Catherine E. Costello, John C. Samuelson, Gustav Ammerer, David E. Levin
Publikováno v:
Journal of Fungi, Vol 7, Iss 10, p 874 (2021)
The cell wall integrity (CWI) signaling pathway is best known for its roles in cell wall biogenesis. However, it is also thought to participate in the response to genotoxic stress. The stress-activated protein kinase Mpk1 (Slt2, is activated by DNA d
Externí odkaz:
https://doaj.org/article/7b30010b9224463eaaf46e83f58641bf
Autor:
Minyong Chen, Xiaofeng Shi, Rebecca M. Duke, Cristian I. Ruse, Nan Dai, Christopher H. Taron, James C. Samuelson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Protein glycosylation is an essential post-translational modification which analysis is complicated by the diversity of glycan composition and heterogeneity at individual attachment sites. Here the authors describe a method to selectively enrich N-li
Externí odkaz:
https://doaj.org/article/63d113807aad4b368c472143cfecb909