Zobrazeno 1 - 10
of 877
pro vyhledávání: '"C, Reinhold"'
Autor:
Camille Tlemsani, Christine M. Heske, Fathi Elloumi, Lorinc Pongor, Prashant Khandagale, Sudhir Varma, Augustin Luna, Paul S. Meltzer, Javed Khan, William C. Reinhold, Yves Pommier
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109781- (2024)
Summary: Sarcomas are a diverse group of rare malignancies composed of multiple different clinical and molecular subtypes. Due to their rarity and heterogeneity, basic, translational, and clinical research in sarcoma has trailed behind that of other
Externí odkaz:
https://doaj.org/article/ebd4320ef1c24a3cbaaa4ee2f674d992
Autor:
Tiannan Guo, Augustin Luna, Vinodh N. Rajapakse, Ching Chiek Koh, Zhicheng Wu, Wei Liu, Yaoting Sun, Huanhuan Gao, Michael P. Menden, Chao Xu, Laurence Calzone, Loredana Martignetti, Chiara Auwerx, Marija Buljan, Amir Banaei-Esfahani, Alessandro Ori, Murat Iskar, Ludovic Gillet, Ran Bi, Jiangnan Zhang, Huanhuan Zhang, Chenhuan Yu, Qing Zhong, Sudhir Varma, Uwe Schmitt, Peng Qiu, Qiushi Zhang, Yi Zhu, Peter J. Wild, Mathew J. Garnett, Peer Bork, Martin Beck, Kexin Liu, Julio Saez-Rodriguez, Fathi Elloumi, William C. Reinhold, Chris Sander, Yves Pommier, Ruedi Aebersold
Publikováno v:
iScience, Vol 21, Iss , Pp 664-680 (2019)
Summary: Here we describe a proteomic data resource for the NCI-60 cell lines generated by pressure cycling technology and SWATH mass spectrometry. We developed the DIA-expert software to curate and visualize the SWATH data, leading to reproducible d
Externí odkaz:
https://doaj.org/article/ccb6206f1f4f4ccf946fcd290d879f5e
Autor:
Vinodh N. Rajapakse, Augustin Luna, Mihoko Yamade, Lisa Loman, Sudhir Varma, Margot Sunshine, Francesco Iorio, Fabricio G. Sousa, Fathi Elloumi, Mirit I. Aladjem, Anish Thomas, Chris Sander, Kurt W. Kohn, Cyril H. Benes, Mathew Garnett, William C. Reinhold, Yves Pommier
Publikováno v:
iScience, Vol 10, Iss , Pp 247-264 (2018)
Summary: CellMinerCDB provides a web-based resource (https://discover.nci.nih.gov/cellminercdb/) for integrating multiple forms of pharmacological and genomic analyses, and unifying the richest cancer cell line datasets (the NCI-60, NCI-SCLC, Sanger/
Externí odkaz:
https://doaj.org/article/735107384b444a4dbe5dd2d94924a21a
Autor:
Camille Tlemsani, Lorinc Pongor, Fathi Elloumi, Luc Girard, Kenneth E. Huffman, Nitin Roper, Sudhir Varma, Augustin Luna, Vinodh N. Rajapakse, Robin Sebastian, Kurt W. Kohn, Julia Krushkal, Mirit I. Aladjem, Beverly A. Teicher, Paul S. Meltzer, William C. Reinhold, John D. Minna, Anish Thomas, Yves Pommier
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108296- (2020)
Summary: CellMiner-SCLC (https://discover.nci.nih.gov/SclcCellMinerCDB/) integrates drug sensitivity and genomic data, including high-resolution methylome and transcriptome from 118 patient-derived small cell lung cancer (SCLC) cell lines, providing
Externí odkaz:
https://doaj.org/article/c3a89008a1ef48f497155a5b22995bc3
Autor:
William C. Reinhold, Fathi Elloumi, Sudhir Varma, Jacques Robert, Gordon B. Mills, Yves Pommier
Publikováno v:
Translational Oncology, Vol 13, Iss 10, Pp 100830- (2020)
Using the information from our CellMiner (https://discover.nci.nih.gov/cellminer/) and CellMinerCDB (https://discover.nci.nih.gov/cellminercdb/) web-based applications, we identified 3978 molecular events with significant links to pharmacological res
Externí odkaz:
https://doaj.org/article/45bbf53bf33a4ae8be3da72f92ff5527
Autor:
Xi Jiang, Chao Hu, Kyle Ferchen, Ji Nie, Xiaolong Cui, Chih-Hong Chen, Liting Cheng, Zhixiang Zuo, William Seibel, Chunjiang He, Yixuan Tang, Jennifer R. Skibbe, Mark Wunderlich, William C. Reinhold, Lei Dong, Chao Shen, Stephen Arnovitz, Bryan Ulrich, Jiuwei Lu, Hengyou Weng, Rui Su, Huilin Huang, Yungui Wang, Chenying Li, Xi Qin, James C. Mulloy, Yi Zheng, Jiajie Diao, Jie Jin, Chong Li, Paul P. Liu, Chuan He, Yuan Chen, Jianjun Chen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Ten-eleven translocation 1 (TET1) is a critical oncoprotein in AML. Here, the authors identify 2 compounds that target the binding of STAT3/5 specifically to the TET1 promoter, inhibiting its expression and AML cell viability.
Externí odkaz:
https://doaj.org/article/a69ded8bba8e453aab53549f9efffc05
Autor:
William C. Reinhold, Kelli Wilson, Fathi Elloumi, Katie R. Bradwell, Michele Ceribelli, Sudhir Varma, Yanghsin Wang, Damien Duveau, Nikhil Menon, Jane Trepel, Xiaohu Zhang, Carleen Klumpp-Thomas, Samuel Michael, Paul Shinn, Augustin Luna, Craig Thomas, Yves Pommier
Publikováno v:
Cancer Research.
Major advances have been made in the field of precision medicine for treating cancer. However, many open questions remain that need to be answered to realize the goal of matching every cancer patient to the most efficacious therapy. To facilitate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28d91ec5c0afec3876524a7a34b42522
https://doi.org/10.1158/0008-5472.can-22-2996
https://doi.org/10.1158/0008-5472.can-22-2996
Autor:
Susan E. Bates, Antonio T. Fojo, Yves Pommier, Owen A. O'Connor, Luigi Scotto, Lubov Petrukhin, Agnes Basseville, William C. Reinhold, Arup R. Chakraborty, Andrés Aguilera, Robert W. Robey, Thomas Litman, Maryam Safari
Supplementary Figures 1-7 and Supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f04256416c03461c4a156fd5e33fa8
https://doi.org/10.1158/1541-7786.22526984
https://doi.org/10.1158/1541-7786.22526984
A profile of microRNA (miRNA) and mRNA expression patterns across the NCI-60 cell-line screen was analyzed to identify expression signatures that correlate with sensitivity to FdUMP[10], fluorouracil (5FU), floxuridine (FdU), topotecan, and irinoteca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53c6ea85db6c6d97ae639d0d8f2727f4
https://doi.org/10.1158/1535-7163.c.6536625.v1
https://doi.org/10.1158/1535-7163.c.6536625.v1
Autor:
Mounira Amor-Guéret, Yves Pommier, William C. Reinhold, Sudhir Varma, Vinodh Rajapakse, Rosine Onclercq-Delic, Sophie Vacher, André Nicolas, Géraldine Buhagiar-Labarchède, Elisabetta Marangoni, Didier Meseure, Ivan Bièche, Hamza Mameri
Purpose: One of the main challenges in cancer therapy is the identification of molecular mechanisms mediating resistance or sensitivity to treatment. Cytidine deaminase (CDA) was reported to be downregulated in cells derived from patients with Bloom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53af0a3890049262cd121f9302d6aff8
https://doi.org/10.1158/1078-0432.c.6526169
https://doi.org/10.1158/1078-0432.c.6526169