Zobrazeno 1 - 10
of 122
pro vyhledávání: '"C, Puozzo"'
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 47:47-58
The biotransformation of vinorelbine (VRL), an anti-neoplastic vinca-alkaloid derivate already marketed for nonsmall cell lung cancer and advanced breast cancer as an i.v. form and currently registered in several countries as an oral form, was invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024d789d09c3074e2d9ab1a06ca02b58
https://doi.org/10.1016/j.jpba.2007.12.006
https://doi.org/10.1016/j.jpba.2007.12.006
Publikováno v:
Journal of Chromatography B. 853:294-302
A sensitive and specific liquid chromatographic method coupled with tandem mass spectrometric detection was set up and fully validated for the simultaneous quantification of vinflunine (VFL) and its pharmacologically active metabolite, 4-O-deacetyl v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57cb235dd3f0323e9147abcc77f268a8
https://doi.org/10.1016/j.jchromb.2007.03.030
https://doi.org/10.1016/j.jchromb.2007.03.030
Autor:
Gilles Vassal, Dominique Méry-Mignard, Charles Caulin, A. Baruchel, A. Benkritly, A. Benzohra, P. Chastagner, R. Defrance, F. Doz, S. Durrleman, J.C. Gentet, N. Hoog-Labouret, C. Lassale, A. Mathieu-Boué, V. Méresse, N. Milpied, L. Normand, C. Puozzo, R. Serreau, P. Trunet, P. Vella, C. Vergely
Publikováno v:
Therapies. 58:229-237
Les cancers de l'enfant et de l'adolescent sont des maladies rares. Malgre les progres therapeutiques accomplis (plus de deux cas sur trois gueris), le cancer demeure la premiere cause de deces par maladie chez l'enfant de plus de 1 an. L'acces a des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::916fa4daa4f8ae43985e037335c62b93
https://doi.org/10.2515/therapie:2003037
https://doi.org/10.2515/therapie:2003037
Autor:
Gilles Vassal, Pascal Chastagner, R. Defrance, P. Vella, C. Vergely, L. Normand, Dominique Méry-Mignard, N. Hoog-Labouret, A. Mathieu-Boué, A. Benkritly, A. Benzohra, C. Puozzo, André Baruchel, R. Serreau, Francois P. Doz, J-C. Gentet, V. Méresse, P. Trunet, N. Milpied, S. Durrleman, Charles Caulin, C. Lassale
Publikováno v:
Therapies. 58:239-246
Childhood and adolescent cancers are rare diseases. Despite the progress in treatment (more than two-thirds of all cases are cured), cancer remains the leading cause of death by disease in children older than 1 year. Access to new drugs that are more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::887e095f436dca4c1713e7acecb5d90f
https://doi.org/10.2515/therapie:2003038
https://doi.org/10.2515/therapie:2003038
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 23:273-279
The pharmacokinetics of single 50 mg oral and intravenous doses of milnacipran, a new non tricyclic antidepressant drug, were compared in 11 chronic liver impaired (LI) subjects and in 6 control subjects. Hepatic impairments, classified according to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc521ebf558b72e5b72fb56263b9df0
https://doi.org/10.1007/bf03189351
https://doi.org/10.1007/bf03189351
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 23:166-171
Milnacipran, a new non tricyclic antidepressant drug, is a racemic mixture (F2207) composed of two enantiomers: F2695 and F2696, both demonstrated to be active. A randomized open label, single-dose latin square study was undertaken in 24 healthy volu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1960719e74de3527b99cf0363c1b0e
https://doi.org/10.1007/bf03189334
https://doi.org/10.1007/bf03189334
Autor:
B E Leonard, C Puozzo
Publikováno v:
International Clinical Psychopharmacology. 11:15-28
Despite the large number of antidepressants currently available, it is still necessary to develop new drugs that combine the efficacy of the older antidepressant with improved safety, tolerability and therapeutic profile that will allow them to be us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf304643a26af85a6d07cd0920bf994
https://doi.org/10.1097/00004850-199609004-00003
https://doi.org/10.1097/00004850-199609004-00003
Publikováno v:
International journal of oncology. 9(5)
The P-glycoprotein (P-gp) multidrug transporter is present at the luminal face of the brain capillary endothelial cells that contribute to the blood-brain barrier. To study its role in transendothelial anticancer drug transport, we made use of a co-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cbac06461440e558a6f7ed30c5bedb6b
https://pubmed.ncbi.nlm.nih.gov/21541610
https://pubmed.ncbi.nlm.nih.gov/21541610
Publikováno v:
Neuropharmacology. 31:149-155
Most antidepressants produce changes in monoamine receptors in brain after chronic administration in animals. The most commonly described alterations are a decreased density and function of β-adrenergic receptors and have been postulated to be the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57cf0d05a3896808a0dc5077d6cd9e9c
https://doi.org/10.1016/0028-3908(92)90025-k
https://doi.org/10.1016/0028-3908(92)90025-k
Publikováno v:
European Journal of Clinical Pharmacology
European Journal of Clinical Pharmacology, Springer Verlag, 2009, 65 (9), pp.903-911. ⟨10.1007/s00228-009-0652-5⟩
European Journal of Clinical Pharmacology, Springer Verlag, 2009, 65 (9), pp.903-911. ⟨10.1007/s00228-009-0652-5⟩
This study was conducted to retrospectively compare the area under the curve (AUC) and the total clearance of busulfan (Bu) following oral and intravenous (IV) administrations and to determine which intravenous dose generated equivalent exposure to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb69ecca7f764fa010494ae127eef64b
https://hal.archives-ouvertes.fr/hal-00534956/document
https://hal.archives-ouvertes.fr/hal-00534956/document
