Zobrazeno 1 - 10
of 120
pro vyhledávání: '"C, Pryde"'
Autor:
Monali Banerjee, Sandip Middya, Ritesh Shrivastava, Sourav Basu, Rajib Ghosh, David C Pryde, Dharmendra B Yadav, Arjun Surya
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0237743 (2020)
The cGAS/STING pathway initiates an innate immune response when DNA is detected in the cytosol. DNA bound cGAS synthesizes cyclic dinucleotides which bind and activate the adaptor STING, leading to downstream secretion of Type I interferons and other
Externí odkaz:
https://doaj.org/article/48220d5a7358405784d8b28a0d496dcd
Publikováno v:
The Medicinal Chemist's Guide to Solving ADMET Challenges ISBN: 9781788012270
Aldehyde oxidase (AO) and xanthine oxidase (XO) are metabolizing enzymes contained within the cytosolic compartments of many tissues and species. In recent years, as drug discovery efforts have increasingly targeted new gene families and new chemotyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2889eb0a82723f6d9d51ea919471284e
https://doi.org/10.1039/9781788016414-00248
https://doi.org/10.1039/9781788016414-00248
Autor:
Marianne Musinszki, Han Sun, Niels Decher, Cristina E. Constantin, Stephen J. Tucker, Marie Tegtmeier, Ümit Mert, Bert L. de Groot, Kirsty S Vowinkel, Thomas Baukrowitz, Bernd Fakler, Linus J. Conrad, Marc Nazaré, Marcus Schewe, Wendy González, David C. Pryde, Ashley C. W. Pike, Elisabeth P. Carpenter, Belabed Hassane, Alexandra Mackenzie, Friederike Schulz, Aytug K. Kiper
Publikováno v:
Science
Potassium (K+) channels have been evolutionarily tuned for activation by diverse biological stimuli, and pharmacological activation is thought to target these specific gating mechanisms. Here we report a class of negatively charged activators (NCAs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327cf97fbaf7dcd1b4aaf65f91eebd7e
https://doi.org/10.1126/science.aav0569
https://doi.org/10.1126/science.aav0569
Autor:
Susan C. Baker, Sabine Kasel, Gregory J. Jordan, Laura G. van Galen, Craig R. Nitschke, Elizabeth C. Pryde
Publikováno v:
Forest Ecology and Management. 433:73-84
In this study, we examined the associations between field-assessed floristic and structural habitat values for mature forest and GIS-derived variables to assess whether high conservation value forests could be predicted for strategic reservation at a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7123d855fca358c9dbf169e0c7a9fb71
https://doi.org/10.1016/j.foreco.2018.10.048
https://doi.org/10.1016/j.foreco.2018.10.048
Autor:
Ritesh Shrivastava, David C. Pryde, Dharmendra Yadav, Abhisek Chatterjee, Sandip Middya, Sameer Shaikh, Rajib Ghosh, Sabyasachi Debnath, Nagaswamy Mane, Anindita Middya, Nidhi Rawat, Anuj Gautam, Sourav Basu, Monali Banerjee, Arjun Surya
Publikováno v:
Cancer Research. 82:2122-2122
Background: Haematopoietic Progenitor Kinase (HPK-1, MAP4K1) is a member of the STE20 family of serine/threonine kinases, expressed predominantly in hematopoietic cells. The kinase activity of HPK-1 provides an inhibitory signal that dampens immune r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0da23ac4143440e1acea4f05f1fe35a4
https://doi.org/10.1158/1538-7445.am2022-2122
https://doi.org/10.1158/1538-7445.am2022-2122
Autor:
Monali Banerjee, Sourav Basu, Sandip Middya, Ritesh Shrivastava, Anindita Middya, Rajib Ghosh, Rubeena R. Mansuri, Nagaswamy Mane, Thanilsana Soram, Dharmendra Yadav, Debjani Chakraborty, Anuj Singh, David C. Pryde, Kavita Puniya, Nidhi Rawat, Arjun Surya
Publikováno v:
Cancer Research. 82:1996-1996
Background: Innate immune signaling mediated through STING (Stimulator of Interferon Genes) generates a Type I interferon (Type 1 IFN) signal that increases T cell infiltration into cold or non-inflamed tumors leading to significant regression1. CRD5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2e2aadea31097cc349261435502e014
https://doi.org/10.1158/1538-7445.am2022-1996
https://doi.org/10.1158/1538-7445.am2022-1996
Autor:
David C Pryde, Lyn H Jones, David P Gervais, David R Stead, David C Blakemore, Matthew D Selby, Alan D Brown, Jotham W Coe, Matthew Badland, David M Beal, Rebecca Glen, Yvonne Wharton, Gavin J Miller, Phil White, Ningli Zhang, Michelle Benoit, Karen Robertson, James R Merson, Heather L Davis, Michael J McCluskie
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76557 (2013)
Anti-nicotine vaccines may aid smoking cessation via the induction of anti-nicotine antibodies (Ab) which reduce nicotine entering the brain, and hence the associated reward. Ab function depends on both the quantity (titer) and the quality (affinity)
Externí odkaz:
https://doaj.org/article/d241124036e24c84ac8c79ff70c995d1
Autor:
Sourav Basu, Sandip Middya, Monali Banerjee, Rajib Ghosh, David C. Pryde, Dharmendra B. Yadav, Ritesh Shrivastava, Arjun Surya
Publikováno v:
European Journal of Medicinal Chemistry. 229:114087
STING mediates innate immune responses that are triggered by the presence of cytosolic DNA. Activation of STING to boost antigen recognition is a therapeutic modality that is currently being tested in cancer patients using nucleic-acid based macrocyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65575e0b01396720d6b390b61a01c364
https://doi.org/10.1016/j.ejmech.2021.114087
https://doi.org/10.1016/j.ejmech.2021.114087
Autor:
Richard O Oduor, Kayode K Ojo, Gareth P Williams, Francois Bertelli, James Mills, Louis Maes, David C Pryde, Tanya Parkinson, Wesley C Van Voorhis, Tod P Holler
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 5, Iss 4, p e1017 (2011)
Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (HAT), expresses two proteins with homology to human glycogen synthase kinase 3β (HsGSK-3) designated TbruGSK-3 short and TbruGSK-3 long. TbruGSK-3 short has previously been va
Externí odkaz:
https://doaj.org/article/93f326b6948e455bba876c91639f9f81
Autor:
Hugh P. Possingham, Steven Schilizzi, James E. M. Watson, Becky Twohey, Carissa J. Klein, Elizabeth C. Pryde, Sayed Iftekhar, Christopher J. Brown, Simon Linke, Glenn Althor, Benjamin S. Halpern
Publikováno v:
Fish and Fisheries. 19:107-116
Almost all environmental management comes at an economic cost that may not be borne equitably by all stakeholders. Here, we investigate how heterogeneity in catch and profits among fishers influences the trade-off among the triple-bottom-line objecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::589e82c9b13a44f942ca351e5b385db4
https://doi.org/10.1111/faf.12240
https://doi.org/10.1111/faf.12240