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Assessment of a defined approach based on a stacking prediction model to identify skin sensitization hazard

Autor: Silvia Teissier, Nathalie Alépée, Ann Detroyer, Thierry Pauloin, C. Piroird, L. Nardelli, Aurélia Del Bufalo, Hicham Noçairi, Fleur Tourneix, Joan Eilstein

Publikováno v: Toxicology in Vitro. 60:134-143

Skin sensitization is an important toxicological endpoint in the safety assessment of chemicals and cosmetic ingredients. Driven by ethical considerations and European Union (EU) legislation, its assessment has progressed from the reliance on traditi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a32b55f948ff069d343fef29814592
https://doi.org/10.1016/j.tiv.2019.05.008

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Accounting for data variability, a key factor inin vivo/in vitrorelationships: application to the skin sensitization potency (in vivoLLNA versusin vitroDPRA) example

Autor: Ovanes G. Mekenyan, Stephanie Ringeissen, Chanita Kuseva, Joan Eilstein, I. Popova, Thierry Pauloin, S. Dimitrov, Yordan H. Karakolev, Ann Detroyer, Hristiana Ivanova, C. Piroird, Charles Gomes

Publikováno v: Journal of Applied Toxicology. 36:1568-1578

When searching for alternative methods to animal testing, confidently rescaling an in vitro result to the corresponding in vivo classification is still a challenging problem. Although one of the most important factors affecting good correlation is sa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2556c7c842aa29c0c3b57617c1f446ca
https://doi.org/10.1002/jat.3318

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Prospective multicentre study of the U-SENS test method for skin sensitization testing

Autor: Nathalie Alépée, A. Hohenstein, Marisa Meloni, L. Nardelli, Cédric Gerbeix, Sebastian Hoffmann, S. Dreyfuss, M. Aujoulat, José Cotovio, C. Piroird

Publikováno v: Toxicology in Vitro. 30:373-382

The U-SENS™ is a test method based on the human myeloid U937 cell line to assess the skin sensitisation potential of substances. To demonstrate its robustness, a multicentre validation study with four laboratories testing 24 coded substances has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ef7e2aa26b881e81dbbb8d70f2cfd3
https://doi.org/10.1016/j.tiv.2015.09.028

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Skin sensitisation testing in practice: Applying a stacking meta model to cosmetic ingredients

Autor: Joan Eilstein, Hicham Noçairi, David A. Basketter, Aurélia Del Bufalo, Fleur Tourneix, Nathalie Alépée, C. Piroird, Mehdi Ez-Zoubir, Ann Detroyer, Silvia Teissier

Publikováno v: Toxicology in Vitro. 66:104831

Recently, several non-animal approaches contributing to the identification of skin sensitisation hazard have been introduced. Their validation and acceptance has largely been directed towards regulatory classification. Considering the driving force f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4375fd00478d8abfbedcf56bc7053bfa
https://doi.org/10.1016/j.tiv.2020.104831

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U-SENS™: A U937 Cell Line Activation Test for Skin Sensitization

Autor: C. Piroird, Nathalie Alépée, L. Nardelli

Publikováno v: Alternatives for Dermal Toxicity Testing ISBN: 9783319503516

The U-SENS™ assay is modelling the dendritic cell activation upon exposure to chemicals. Upon contact with sensitizers, U937 human histiocytic lymphoma cells are activated and increase the CD86 expression. The U-SENS™ assay addressing one biologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a42436274edfa44eea64e5593a595d9
https://doi.org/10.1007/978-3-319-50353-0_22

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Accounting for data variability, a key factor in in vivo/in vitro relationships: application to the skin sensitization potency (in vivo LLNA versus in vitro DPRA) example

Autor: S, Dimitrov, A, Detroyer, C, Piroird, C, Gomes, J, Eilstein, T, Pauloin, C, Kuseva, H, Ivanova, I, Popova, Y, Karakolev, S, Ringeissen, O, Mekenyan

Publikováno v: Journal of applied toxicology : JAT. 36(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a9861fcebbdab4fff8c1b96bc9a2ca3
https://pubmed.ncbi.nlm.nih.gov/27080242

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