Zobrazeno 1 - 10
of 453
pro vyhledávání: '"C, Pflugfelder"'
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
PurposeThe purpose of this study is to characterize and discuss the difference between software-detected non-invasive tear break-up time (NIBUT) and the traditional clinical method of fluorescein break-up time (FBUT).MethodsTear interferometry with t
Externí odkaz:
https://doaj.org/article/dc69bdc84f5143d1b4af5cfb09741286
Autor:
Jehan Alam, Ebru Yaman, Gerda Cristal Villalba Silva, Rui Chen, Cintia S. de Paiva, Mary Ann Stepp, Stephen C. Pflugfelder
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundDry eye causes corneal inflammation, epitheliopathy and sensorineural changes. This study evaluates the hypothesis that dry eye alters the percentages and transcriptional profiles of immune cell populations in the cornea.MethodsDesiccating
Externí odkaz:
https://doaj.org/article/c8e026646a93472e9ccdb513fbe761c9
Autor:
Xin Chen, Na Lin, Jin-Miao Li, Haixia Liu, Anmar Abu-Romman, Ebru Yaman, Fang Bian, Cintia S. de Paiva, Stephen C. Pflugfelder, De-Quan Li
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 236 (2024)
Ectoine, a novel natural osmoprotectant, protects bacteria living in extreme environments. This study aimed to explore the therapeutic effect of ectoine for dry eye disease. An experimental dry eye model was created in C57BL/6 mice exposed to desicca
Externí odkaz:
https://doaj.org/article/ad818e3812ca4ed39de3fc488946258a
Autor:
Laura Schaefer, Humberto Hernandez, Rosalind A. Coats, Zhiyuan Yu, Stephen C. Pflugfelder, Robert A. Britton, Cintia de Paiva
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Dry eye is a common ocular inflammatory disorder characterized by tear film instability and reduced tear production. There is increasing evidence that homeostasis of the ocular surface is impacted by the intestinal microbiome. We are interes
Externí odkaz:
https://doaj.org/article/1f1be2f4e7094b8180537e0a031637bb
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0282973 (2023)
PurposeDry eye disease affects hundreds of millions of people worldwide and is one of the most common causes for visits to eye care practitioners. The fluorescein tear breakup time test is currently widely used to diagnose dry eye disease, but it is
Externí odkaz:
https://doaj.org/article/d21ed547414f40f3a8208b323e5d2bd0
Autor:
Laura Schaefer, Claudia M. Trujillo-Vargas, Firas S. Midani, Stephen C. Pflugfelder, Robert A. Britton, Cintia S. de Paiva
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Sjögren syndrome (SS) is an autoimmune inflammatory disorder characterized by secretory dysfunction in the eye and mouth; in the eye, this results in tear film instability, reduced tear production, and corneal barrier disruption. A growing number of
Externí odkaz:
https://doaj.org/article/82f81fe5100840b3a77b5388b138b2a0
Autor:
Jehan Alam, Ghasem Yazdanpanah, Rinki Ratnapriya, Nicholas Borcherding, Cintia S. de Paiva, DeQuan Li, Rodrigo Guimaraes de Souza, Zhiyuan Yu, Stephen C. Pflugfelder
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
PurposeTo investigate IL-17 related mechanisms for developing dry eye disease in the Pinkie mouse strain with a loss of function RXRα mutation.MethodsMeasures of dry eye disease were assessed in the cornea and conjunctiva. Expression profiling was p
Externí odkaz:
https://doaj.org/article/29afba3f78fa49938e0e6e66b5c929a5
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundLacrimal gland secretory dysfunction in Sjögren syndrome (SS) causes ocular surface desiccation that is associated with increased cytokine expression and number of antigen-presenting cells (APCs) in the conjunctiva. This study evaluated th
Externí odkaz:
https://doaj.org/article/18b35be4d3da43db889ab24d2f012afd
Autor:
Cintia S. de Paiva, Claudia M. Trujillo-Vargas, Laura Schaefer, Zhiyuan Yu, Robert A. Britton, Stephen C. Pflugfelder
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Sjögren syndrome (SS) is an autoimmune condition that targets the salivary and lacrimal glands, with cardinal clinical signs of dry eye (keratoconjunctivitis sicca, KCS) and dry mouth. The conjunctiva of SS patients is often infiltrated by immune ce
Externí odkaz:
https://doaj.org/article/291289ef77dd440e97e9a018bfa9dc89
Autor:
Laura Schaefer, Humberto Hernandez, Rosalind A. Coats, Zhiyuan Yu, Stephen C. Pflugfelder, Robert A. Britton, Cintia S. de Paiva
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/3f96fca41920452d9b4f8698ba211233