Zobrazeno 1 - 10
of 187
pro vyhledávání: '"C, Panchal"'
Autor:
Eric R. Goedken, Maria A. Argiriadi, Justin D. Dietrich, Andrew M. Petros, Navasona Krishnan, Sanjay C. Panchal, Wei Qiu, Haihong Wu, Haizhong Zhu, Ashley M. Adams, Pierre M. Bodelle, Lucas Goguen, Paul L. Richardson, Peter F. Slivka, Myron Srikumaran, Anup K. Upadhyay, Bainan Wu, Russell A. Judge, Anil Vasudevan, Sujatha M. Gopalakrishnan, Philip B. Cox, Vincent S. Stoll, Chaohong Sun
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Anti-IL17A therapies have proven effective for numerous inflammatory diseases including psoriasis, axial spondylitis and psoriatic arthritis. Modulating and/or antagonizing protein–protein interactions of IL17A cytokine binding to its cell
Externí odkaz:
https://doaj.org/article/73a129f16e244becaaa09ce714e81a66
Autor:
John T. Randolph, Matthew J. O’Connor, Fei Han, Charles W. Hutchins, Y. Amy Siu, Min Cho, Yunan Zheng, Jonathan A. Hickson, Jana L. Markley, Vlasios Manaves, Mikkel Algire, Kenton A. Baker, Alex M. Chapman, Sujatha M. Gopalakrishnan, Sanjay C. Panchal, Kelly Foster-Duke, DeAnne F. Stolarik, Anita Kempf-Grote, Darby Dammeier, Stacey Fossey, Qi Sun, Chaohong Sun, Yu Shen, Michael J. Dart, Warren M. Kati, Albert Lai, Ari J. Firestone, Michael E. Kort
Publikováno v:
Journal of Medicinal Chemistry. 66:3852-3865
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::941bc4bfb75cae4284f6cb7de0cad715
https://doi.org/10.1021/acs.jmedchem.2c01415
https://doi.org/10.1021/acs.jmedchem.2c01415
Autor:
David Maag, Julie L. Wilsbacher, Eric F. Johnson, Amanda M. Olson, Yan Shi, Mikkel A. Algire, Vivek C. Abraham, Sanjay C. Panchal, Enrico L. DiGiammarino, Cherrie K. Donawho, Paul A. Ellis, William B. Ainsworth, Todd A. Hopkins
Bone Marrow IC50s broken into cell type.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e498c80f13b9c6f3eef5213b00c9a4
https://doi.org/10.1158/1541-7786.22514770
https://doi.org/10.1158/1541-7786.22514770
Autor:
David Maag, Eric F. Johnson, Donald J. Osterling, DeAnne F. Stolarik, Amanda M. Olson, Wenqing Gao, Julie L. Wilsbacher, Sanjay C. Panchal, Enrico L. DiGiammarino, Cherrie K. Donawho, Larry R. Solomon, Luis E. Rodriguez, Yan Shi, Todd A. Hopkins
Supplementary figures S1-S6, tables 1 and 2. Table S1. Body weight loss and health observations in HeyA8 xenograft tumor-bearing mice treated with PARP inhibitors or TMZ alone or in combination. Table S2. Summary of PK parameters in HeyA8 xenograft t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcfa08a35c000c13a490792d1596a75
https://doi.org/10.1158/1541-7786.22514481.v1
https://doi.org/10.1158/1541-7786.22514481.v1
Autor:
David Maag, Julie L. Wilsbacher, Eric F. Johnson, Amanda M. Olson, Yan Shi, Mikkel A. Algire, Vivek C. Abraham, Sanjay C. Panchal, Enrico L. DiGiammarino, Cherrie K. Donawho, Paul A. Ellis, William B. Ainsworth, Todd A. Hopkins
Association of PARP1 and H2A.X detected by Proximity Ligation Assay (PLA).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d490333306545aace2682f34c3fb2b1
https://doi.org/10.1158/1541-7786.22514785.v1
https://doi.org/10.1158/1541-7786.22514785.v1
Autor:
Edward B. Reilly, Andrew M. Scott, Hui K. Gan, Diana Cao, Sherry L. Ralston, Lise I. Loberg, Sarah R. Mudd, David R. Reuter, Martin J. Voorbach, Kenneth R. Durbin, Fritz G. Buchanan, Sanjay C. Panchal, Jonathan A. Meulbroek, Chung-Ming Hsieh, Lorenzo Benatuil, Peter J. DeVries, Michael J. Mitten, Hugh D. Falls, Kedar S. Vaidya, Erwin R. Boghaert, Andrew C. Phillips
Amino Acid Sequence of AM-1 VH Region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4690d3c6ba234726f181827c74d28b66
https://doi.org/10.1158/1535-7163.22505197
https://doi.org/10.1158/1535-7163.22505197
Autor:
Susan E. Morgan-Lappe, Jijie Gu, Louie Naumovski, Sherry L. Ralston, Wenqing Gao, Surekha S. Akella, Catherine Zhang, Sarah R. Mudd, Fang Jiang, Sanjay C. Panchal, Enrico L. DiGiammarino, Lucia J. Eaton, Kelly D. Foster-Duke, Deanna L. Haasch, Dominic J. Ambrosi, Jonathan A. Hickson, Yingchun Li
Table S1: ABT-165 binding affinity; Table S2: ABT-165 in vitro potency; Table S3: Effect of VEGF on anti-DLL4 cellular potency of ABT-165; Table S4: Summary of in vivo efficacy; Table S5: Key safety findings of ABT-487 and ABT-165; Figure S1: Serum c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948fdfba3f05b8a422e19034176fe36d
https://doi.org/10.1158/1535-7163.22505686
https://doi.org/10.1158/1535-7163.22505686
Autor:
Edward B. Reilly, Andrew M. Scott, Hui K. Gan, Diana Cao, Sherry L. Ralston, Lise I. Loberg, Sarah R. Mudd, David R. Reuter, Martin J. Voorbach, Kenneth R. Durbin, Fritz G. Buchanan, Sanjay C. Panchal, Jonathan A. Meulbroek, Chung-Ming Hsieh, Lorenzo Benatuil, Peter J. DeVries, Michael J. Mitten, Hugh D. Falls, Kedar S. Vaidya, Erwin R. Boghaert, Andrew C. Phillips
Depatuxizumab mafodotin (depatux-m, ABT-414) is a tumor-selective antibody drug conjugate (ADC) comprised of the anti-EGFR antibody ABT-806 and the monomethyl auristatin F (MMAF) warhead. Depatux-m has demonstrated promising clinical activity in glio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::313f2d242d9ae4aea09b4db055c77042
https://doi.org/10.1158/1535-7163.c.6537985.v1
https://doi.org/10.1158/1535-7163.c.6537985.v1
Autor:
David Maag, Julie L. Wilsbacher, Eric F. Johnson, Amanda M. Olson, Yan Shi, Mikkel A. Algire, Vivek C. Abraham, Sanjay C. Panchal, Enrico L. DiGiammarino, Cherrie K. Donawho, Paul A. Ellis, William B. Ainsworth, Todd A. Hopkins
Association of PARP1 and other histone proteins detected by Proximity Ligation Assay (PLA).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a73200cd0e0b2826cfb29f9594a526
https://doi.org/10.1158/1541-7786.22514782
https://doi.org/10.1158/1541-7786.22514782
Autor:
Susan E. Morgan-Lappe, Jijie Gu, Louie Naumovski, Sherry L. Ralston, Wenqing Gao, Surekha S. Akella, Catherine Zhang, Sarah R. Mudd, Fang Jiang, Sanjay C. Panchal, Enrico L. DiGiammarino, Lucia J. Eaton, Kelly D. Foster-Duke, Deanna L. Haasch, Dominic J. Ambrosi, Jonathan A. Hickson, Yingchun Li
This file describes the binding assay details of surface plasmon resonance technology, ligand and receptor binding competition assays, western blot detection of DLL4 protein down-regulation, and the methods to measure total circulating soluble DLL4 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267ca9367d459176dea46bdd55158c64
https://doi.org/10.1158/1535-7163.22505689.v1
https://doi.org/10.1158/1535-7163.22505689.v1