Zobrazeno 1 - 10 of 4 595 pro vyhledávání: '"C, Ou"'
1
Akademický článek
In vivo screening for toxicity-modulating drug interactions identifies antagonism that protects against ototoxicity in zebrafish
Autor: Ethan Bustad, Emma Mudrock, Elizabeth M. Nilles, Andrea Mcquate, Monica Bergado, Alden Gu, Louie Galitan, Natalie Gleason, Henry C. Ou, David W. Raible, Rafael E. Hernandez, Shuyi Ma
Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Ototoxicity is a debilitating side effect of over 150 medications with diverse mechanisms of action, many of which could be taken concurrently to treat multiple conditions. Approaches for preclinical evaluation of drug-drug interactions
Externí odkaz: https://doaj.org/article/5b337905b38c463383e4f19a5a9a8ec3
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3
Akademický článek
Comprehensive PBPK model to predict drug interaction potential of Zanubrutinib as a victim or perpetrator
Autor: Kun Wang, Xueting Yao, Miao Zhang, Dongyang Liu, Yuying Gao, Srikumar Sahasranaman, Ying C. Ou
Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 5, Pp 441-454 (2021)
Abstract A physiologically based pharmacokinetic (PBPK) model was developed to evaluate and predict (1) the effect of concomitant cytochrome P450 3A (CYP3A) inhibitors or inducers on the exposures of zanubrutinib, (2) the effect of zanubrutinib on th
Externí odkaz: https://doaj.org/article/c6ef1cbd2e704a50ba2bf248d270e404
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4
Akademický článek
Population Pharmacokinetic Analysis of the BTK Inhibitor Zanubrutinib in Healthy Volunteers and Patients With B‐Cell Malignancies
Autor: Ying C. Ou, Lucy Liu, Bilal Tariq, Kun Wang, Ashutosh Jindal, Zhiyu Tang, Yuying Gao, Srikumar Sahasranaman
Publikováno v: Clinical and Translational Science, Vol 14, Iss 2, Pp 764-772 (2021)
Zanubrutinib is a potent, second‐generation Bruton’s tyrosine kinase inhibitor that is currently being investigated in patients with B‐cell malignancies and recently received accelerated approval in the United States for treatment of relapsed/r
Externí odkaz: https://doaj.org/article/879d1e514a2645fb9a2b15ee786ead7c
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5
Akademický článek
No QTc Prolongation With Zanubrutinib: Results of Concentration‐QTc Analysis From a Thorough QT Study in Healthy Subjects
Autor: Song Mu, Borje Darpo, Zhiyu Tang, William Novotny, Manal Tawashi, Hongqi Xue, Michael Willett, Leo Lin, Sri Sahasranaman, Ying C. Ou
Publikováno v: Clinical and Translational Science, Vol 13, Iss 5, Pp 923-931 (2020)
This thorough QT (TQT) study evaluated the effect of zanubrutinib on electrocardiogram (ECG) parameters by using concentration‐QTc (C‐QTc) analysis as the primary analysis for this study. Part A of the study determined the safety and tolerability
Externí odkaz: https://doaj.org/article/e0ea160c88114e70927aa41ba7867992
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6
Akademický článek
In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor
Autor: Heather Zhang, Ying C. Ou, Dan Su, Fan Wang, Lai Wang, Srikumar Sahasranaman, Zhiyu Tang
Publikováno v: Pharmacology Research & Perspectives, Vol 9, Iss 6, Pp n/a-n/a (2021)
Abstract Zanubrutinib is a highly selective, potent, orally available, targeted covalent inhibitor (TCI) of Bruton's tyrosine kinase (BTK). This work investigated the in vitro drug metabolism and transport of zanubrutinib, and its potential for clini
Externí odkaz: https://doaj.org/article/5b5ab68ce63d4effa6ef18a32a9a79e9
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8
Akademický článek
Robotic-assisted radical prostatectomy in kidney transplant patients: An initial experience in Taiwan
Autor: W-S. Hu, Y-S. Lin, Y-C. Ou, C-Y. Shu, M-C. Tung
Publikováno v: European Urology Open Science, Vol 19, Iss , Pp e2366- (2020)
Externí odkaz: https://doaj.org/article/dce7195bcd654ce1a450a0e53bc82887
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