Zobrazeno 1 - 10
of 1 119
pro vyhledávání: '"C, Luca"'
Autor:
Gregory Foran, Ryan Douglas Hallam, Marvel Megaly, Anel Turgambayeva, Daniel Antfolk, Yifeng Li, Vincent C. Luca, Aleksandar Necakov
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-24 (2024)
Abstract The Notch receptor is a pleiotropic signaling protein that translates intercellular ligand interactions into changes in gene expression via the nuclear localization of the Notch intracellular Domain (NICD). Using a combination of immunohisto
Externí odkaz:
https://doaj.org/article/6d4d0b894b754364b151eb9c1ceaea6b
Autor:
Qianqian Ming, Daniel Antfolk, David A. Price, Anna Manturova, Elliot Medina, Srishti Singh, Charlotte Mason, Timothy H. Tran, Keiran S. M. Smalley, Daisy W. Leung, Vincent C. Luca
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The immune checkpoint protein, Lymphocyte activation gene-3 (LAG3), binds Major Histocompatibility Complex Class II (MHC-II) and suppresses T cell activation. Despite the recent FDA approval of a LAG3 inhibitor for the treatment of melanoma,
Externí odkaz:
https://doaj.org/article/7b12d9f7a4494fceb98b9a25a6dc0b12
Autor:
Ioanna Smyrlaki, Ferenc Fördős, Iris Rocamonde-Lago, Yang Wang, Boxuan Shen, Antonio Lentini, Vincent C. Luca, Björn Reinius, Ana I. Teixeira, Björn Högberg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The Notch signaling pathway has fundamental roles in embryonic development and in the nervous system. The current model of receptor activation involves initiation via a force-induced conformational change. Here, we define conditions that rev
Externí odkaz:
https://doaj.org/article/e0cd4cdde23c495385b0467afe5fe727
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Fat and Dachsous are large cadherins that regulate planar polarity as a receptor:ligand pair. Here, authors determine the structure of the Fat:Dachsous complex to uncover the molecular determinants of binding and posttranslational modification.
Externí odkaz:
https://doaj.org/article/26c914ba27a3409fbe4efea1685f878a
Autor:
Paulo F. Santos, Beatriz Fazendeiro, Francis C. Luca, António Francisco Ambrósio, Hélène Léger
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 2, Pp 151333- (2023)
Nuclear Dbf2-related (NDR) kinases are a subgroup of evolutionarily conserved AGC protein kinases that regulate various aspects of cell growth and morphogenesis. There are 4 NDR protein kinases in mammals, LATS1, LATS2 and STTK8/NDR1, STK38L/NDR2 pro
Externí odkaz:
https://doaj.org/article/36fd8a03331e478399c077f03bde73f4
Autor:
H. SĂRĂNDAN, ANA PIVODĂ, D. DRÎNCEANU, ANA SAUER, OLGA RADA, LILIANA CĂRPINIŞAN, CLAUDIA SALA, S. VOIA, C. LUCA
Publikováno v:
Scientific Papers Animal Science and Biotechnologies, Vol 42, Iss 1, Pp 267-267 (2023)
In the extraction process of the vegetable soy oils and sun-flower oils results in large quantities a waste that contains approximately 45% fat from which 58% is lecithin. This waste called “dreg” creates problems of environment pollution because
Externí odkaz:
https://doaj.org/article/70823be090734fd5a5cf6e5bc6fc66d8
Autor:
Erika d. l. R. M. Cabrera Ranaldi, Karen Nuytemans, Anisley Martinez, Corneliu C. Luca, Robert W. Keane, Juan Pablo de Rivero Vaccari
Publikováno v:
Pharmaceuticals, Vol 16, Iss 6, p 883 (2023)
Parkinson’s disease (PD) is a neurodegenerative disorder marked by the death of dopaminergic neurons in the midbrain, the accumulation of α-synuclein aggregates, and motor deficits. A major contributor to dopaminergic neuronal loss is neuroinflamm
Externí odkaz:
https://doaj.org/article/331846a8ebea45b381b9a5bbbe923df4
Autor:
Stephano J. Chang, Iahn Cajigas, James D. Guest, Brian R. Noga, Eva Widerström-Noga, Ihtsham Haq, Letitia Fisher, Corneliu C. Luca, Jonathan R. Jagid
Publikováno v:
Pilot and Feasibility Studies, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Background Freezing of gait (FOG) is a particularly debilitating motor deficit seen in a subset of Parkinson’s disease (PD) patients that is poorly responsive to standard levodopa therapy or deep brain stimulation (DBS) of established PD t
Externí odkaz:
https://doaj.org/article/e8b04a178551404f86616752154e9bfe
Autor:
J. Sebastian Marquez, S. M. Shafiul Hasan, Masudur R. Siddiquee, Corneliu C. Luca, Virendra R. Mishra, Zoltan Mari, Ou Bai
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/c03932da885c4f56b106fe4483e3cf31
Autor:
Laura M. Trandafir, Gianina Dodi, Otilia Frasinariu, Alina C. Luca, Lacramioara I. Butnariu, Elena Tarca, Stefana M. Moisa
Publikováno v:
Nutrients, Vol 14, Iss 18, p 3774 (2022)
Obesity and dyslipidemia are the main features of metabolic syndrome, expressed mainly by adipose tissue dysfunction and connected by similar pathways and pharmacotherapy. Conventional drugs used in these two associated disorders are limited due to p
Externí odkaz:
https://doaj.org/article/fec5653e715145beb1b233f55314d6e2