Zobrazeno 1 - 10
of 759
pro vyhledávání: '"C, Langston"'
Autor:
Archie A. Khan, Harry C. Langston, Louis Walsh, Rebecca Roscoe, Shiromani Jayawardhana, Amanda Fortes Francisco, Martin C. Taylor, Conor J. McCann, John M. Kelly, Michael D. Lewis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Digestive Chagas disease (DCD) is an enteric neuropathy caused by Trypanosoma cruzi infection. There is a lack of evidence on the mechanism of pathogenesis and rationales for treatment. We used a female C3H/HeN mouse model that recapitulates
Externí odkaz:
https://doaj.org/article/a4a52838d7184b1199e085504845f411
Autor:
Qingliang Yang, Jordan C. Langston, Roman Prosniak, Samantha Pettigrew, Huaqing Zhao, Edwin Perez, Hannah Edelmann, Nadia Mansoor, Carmen Merali, Salim Merali, Nathaniel Marchetti, Balabhaskar Prabhakarpandian, Mohammad F. Kiani, Laurie E. Kilpatrick
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
PurposeSepsis is a clinical syndrome defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis is a highly heterogeneous syndrome with distinct phenotypes that impact immune function and response to inf
Externí odkaz:
https://doaj.org/article/4a549513b5354850bcc150fe7987e872
Autor:
Dan Liu, Jordan C. Langston, Balabhaskar Prabhakarpandian, Mohammad F. Kiani, Laurie E. Kilpatrick
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2024)
Sepsis is a global health concern accounting for more than 1 in 5 deaths worldwide. Sepsis is now defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis can develop from bacterial (gram negative or g
Externí odkaz:
https://doaj.org/article/2075bf0ecf0a44f586a6623f3f920686
Autor:
Brandon J. Durr, Larry D. Ballard, Angela D. Knight, Keun-Seok Seo, Vernon C. Langston, Alexis C. Thompson, Jacob M. Shivley, W. Cooper Brookshire
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
The objective of this study was to assess the use of breakpoints in antibiotic susceptibility testing among veterinary diagnostic laboratories in the United States and Canada. An eight-question survey was conducted via phone and email to determine ho
Externí odkaz:
https://doaj.org/article/d1420ced16e84cd6a51946b8b0d627e5
Autor:
Jordan C Langston, Michael T Rossi, Qingliang Yang, William Ohley, Edwin Perez, Laurie E Kilpatrick, Balabhaskar Prabhakarpandian, Mohammad F Kiani
Publikováno v:
Vascular Biology, Vol 4, Iss 1, Pp R15-R34 (2022)
During sepsis, defined as life-threatening organ dysfunction due to dysregulated host response to infection, systemic inflammation activates endothelial cells and initiates a multifaceted cascade of pro-inflammatory signaling events, resulting in inc
Externí odkaz:
https://doaj.org/article/95cdab2dcca64d429a1149bc75f259c8
Autor:
Archie A Khan, Harry C Langston, Fernanda C Costa, Francisco Olmo, Martin C Taylor, Conor J McCann, John M Kelly, Michael D Lewis
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009864 (2021)
Digestive Chagas disease (DCD) is an enteric neuropathy caused by Trypanosoma cruzi infection. The mechanism of pathogenesis is poorly understood and the lack of a robust, predictive animal model has held back research. We screened a series of mouse
Externí odkaz:
https://doaj.org/article/ce5e49f6159a4b51957df35aa743d66a
Molecular Framework of Mouse Endothelial Cell Dysfunction during Inflammation: A Proteomics Approach
Autor:
Michael T. Rossi, Jordan C. Langston, Narender Singh, Carmen Merali, Qingliang Yang, Salim Merali, Balabhaskar Prabhakarpandian, Laurie E. Kilpatrick, Mohammad F. Kiani
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8399 (2022)
A key aspect of cytokine-induced changes as observed in sepsis is the dysregulated activation of endothelial cells (ECs), initiating a cascade of inflammatory signaling leading to leukocyte adhesion/migration and organ damage. The therapeutic targeti
Externí odkaz:
https://doaj.org/article/6887651aebb04a9bb11721d4229e01ab
Autor:
Yuan Tang, Fariborz Soroush, Shuang Sun, Elisabetta Liverani, Jordan C. Langston, Qingliang Yang, Laurie E. Kilpatrick, Mohammad F. Kiani
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-12 (2018)
Abstract Background Neuroinflammation often develops in sepsis leading to activation of cerebral endothelium, increased permeability of the blood-brain barrier (BBB), and neutrophil infiltration. We have identified protein kinase C-delta (PKCδ) as a
Externí odkaz:
https://doaj.org/article/9f091d5655cd4b088b3c8f43be588711
Publikováno v:
Shock. 59:224-231
Sepsis is a major health issue and a leading cause of death in hospitals globally. The treatment of sepsis is largely supportive and there are no therapeutics available that target the underlying pathophysiology of the disease. The development of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d74d34269cd4660e465ea751498454
https://doi.org/10.1097/shk.0000000000002047
https://doi.org/10.1097/shk.0000000000002047
Autor:
Qingliang Yang, Harshani Wijerathne, Jordan C. Langston, Mohammad F. Kiani, Laurie E. Kilpatrick
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 7770 (2021)
The endothelium is the inner layer of all blood vessels and it regulates hemostasis. It also plays an active role in the regulation of the systemic inflammatory response. Systemic inflammatory disease often results in alterations in vascular endothel
Externí odkaz:
https://doaj.org/article/c34f57b236214d4ba7a530a9d97e4d56