Response-rate suppression in operant paradigm as predictor of soporific potency in rats and identification of three novel sedative-hypnotic neuroactive steroids.

Autor: E, Vanover K, M, Edgar D, F, Seidel W, J, Hogenkamp D, B, Fick D, C, Lan N, W, Gee K, B, Carter R

Publikováno v: The Journal of Pharmacology and Experimental Therapeutics; December 1999, Vol. 291 Issue: 3 p1317-23, 7p

CCD-3693: an orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the rat.

Autor: M, Edgar D, F, Seidel W, W, Gee K, C, Lan N, G, Field, H, Xia, E, Hawkinson J, S, Wieland, B, Carter R, L, Wood P

Publikováno v: The Journal of Pharmacology and Experimental Therapeutics; July 1997, Vol. 282 Issue: 1 p420-9, 10p

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.

Autor: B, Carter R, L, Wood P, S, Wieland, E, Hawkinson J, D, Belelli, J, Lambert J, S, White H, H, Wolf H, S, Mirsadeghi, H, Tahir S, B, Bolger M, C, Lan N, W, Gee K

Publikováno v: The Journal of Pharmacology and Experimental Therapeutics; March 1997, Vol. 280 Issue: 3 p1284-95, 12p