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Autor:
Saadia Eddahibi, Marc Humbert, Marie Pia d'Ortho, H. Lepetit, E. Fadel, Serge Adnot, C. Lafuma, Agnès Noël, Carine Munaut, Eric Frisdal
Publikováno v:
European Respiratory Journal. 25:834-842
Pulmonary arterial hypertension (PAH) results from persistent vasoconstriction, smooth muscle growth and extracellular matrix (ECM) remodelling of pulmonary arteries (PAs). Matrix metalloproteinases (MMPs) are matrix-degrading enzymes involved in ECM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56410dc7a98f848a68e06e4de7a581e7
https://doi.org/10.1183/09031936.05.00072504
https://doi.org/10.1183/09031936.05.00072504
Autor:
Marie Pia d'Ortho, Daniel Jean, Andry Van de Louw, C. Lafuma, Christophe Delclaux, Andrew H. Baker, Charles Cerf, Eric Frisdal, Philippe Duvaldestin, Alain Harf
Publikováno v:
Laboratory Investigation. 82:133-145
We investigated the role of polymorphonuclear neutrophil (PMN) proteinases, elastase, and gelatinase B in rat models of acute lung injury. Three groups of rats were studied 6 hours after unilateral instillation of hydrochloric acid (HCl; 0.1 N), lipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7104463d90b82e4b2a80b54b97fb20
https://doi.org/10.1038/labinvest.3780406
https://doi.org/10.1038/labinvest.3780406
Autor:
M Levame, Eric Frisdal, Saadia Eddahibi, Marie Pia d'Ortho, Serge Adnot, Antoine Vieillard-Baron, H. Lepetit, C. Lafuma, V Gest, Alain Harf
Publikováno v:
European Respiratory Journal. 18:838-845
Structural remodelling of pulmonary vessels is an important feature of pulmonary hypertension (PH), which reflects distal artery muscularization and matrix remodelling. The matrix metalloproteinases (MMPs) are involved in extracellular matrix turnove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762b5b05915411c94bfbd2be0b609f8a
https://doi.org/10.1183/09031936.01.00084601
https://doi.org/10.1183/09031936.01.00084601
Autor:
Eric Frisdal, Estelle Escudier, Alain Harf, Marie Pia d'Ortho, Emmanuèle Lechapt-Zalcman, André Coste, C. Lafuma
Publikováno v:
The Journal of Pathology. 193:233-241
To investigate the role of gelatinases in nasal polyposis, a common and disabling airway disease characterized by chronic inflammation and tissue remodelling, matrix metalloproteinase-2 (MMP-2) and MMP-9 expression was investigated in the nasal polyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce85e9d0d48eea4df82c39474574f571
https://doi.org/10.1002/1096-9896(2000)9999:9999<::aid-path771>3.0.co
https://doi.org/10.1002/1096-9896(2000)9999:9999<::aid-path771>3.0.co
Autor:
Sophie Pezet, J. P. Bertrand, Quang Thieu Pham, C. Frette, Francine Kauffmann, Rita Azzi El Nabout, C. Lafuma
Publikováno v:
Alcoholism: Clinical and Experimental Research. 22:1405-1408
Neutral endopeptidase (NEP) is an ubiquitous enzyme that inactivates numerous endogenous peptides in the brain, kidney, and lung in vivo. The origin of the circulating soluble form and its determinants are largely unknown. The relationships of smokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68ed7f0fe36002e7ec9a5a255e3a375
https://doi.org/10.1111/j.1530-0277.1998.tb03927.x
https://doi.org/10.1111/j.1530-0277.1998.tb03927.x
Autor:
Marie Pia d'Ortho, Bruno Housset, Christophe Delacourt, C. Lafuma, Alain Harf, Sophie Pezet, Isabelle Macquin-Mavier
Publikováno v:
European Respiratory Journal. 9:2517-2524
An oxidant-antioxidant imbalance in neonatal alveolar macrophages (AMs) may contribute to the increased susceptibility to lung injury described in the neonatal period. We therefore evaluated oxygen radical production by rat AMs at various postnatal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80089a7fa4f6bc86652c341c72c98ba0
https://doi.org/10.1183/09031936.96.09122517
https://doi.org/10.1183/09031936.96.09122517
Publikováno v:
European Journal of Clinical Investigation. 26:1011-1017
A previous epidemiological study has reported the elevation of a serum metalloendopeptidase activity for underground coalminers exposed to chronic inhalation of coal mine dust particles. In this work, we have unambiguously characterized this activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f644c4b33dd807bb37fb74cef80dccd9
https://doi.org/10.1046/j.1365-2362.1996.2420580.x
https://doi.org/10.1046/j.1365-2362.1996.2420580.x
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 1996, 270 (5), pp.L761-L771
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 1996, 270 (5), pp.L761-L771
After isolation, purification, and radiolabeling of elastin from baboon aorta and lung, the rates of hydrolysis of both 3H-labeled elastins by porcine pancreatic elastase (PPE or by human leukocyte elastase (HLE) were compared. PPE (30 nM) degraded a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63149e7eea4bace50a67db40753d486
https://doi.org/10.1152/ajplung.1996.270.5.l761
https://doi.org/10.1152/ajplung.1996.270.5.l761
Publikováno v:
Pathology - Research and Practice. 190:895-902
Heparin and heparan sulfate, exhibiting wide biological interactions, are constituted of block structures. A defined pentasaccharide motif was found responsible for the enhancement of the rate of inactivation of factor Xa by antithrombin III. Heparin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::584280adec5b3c7828a903112bc57433
https://doi.org/10.1016/s0344-0338(11)80993-3
https://doi.org/10.1016/s0344-0338(11)80993-3