Zobrazeno 1 - 10
of 769
pro vyhledávání: '"C, Léger"'
Autor:
Howard H Feldman, José A Luchsinger, Gabriel C Léger, Curtis Taylor, Diane M Jacobs, David P Salmon, Steven D Edland, Karen Messer, Carolyn Revta, Sarah A Flowers, Kerry S Jones, Albert Koulman, Kevin E Yarasheski, Philip B Verghese, Venky Venkatesh, Henrik Zetterberg, January Durant, Jody-Lynn Lupo, Gary E Gibson, ADCS BenfoTeam Study Group
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0302998 (2024)
BackgroundBenfotiamine provides an important novel therapeutic direction in Alzheimer's disease (AD) with possible additive or synergistic effects to amyloid targeting therapeutic approaches.ObjectiveTo conduct a seamless phase 2A-2B proof of concept
Externí odkaz:
https://doaj.org/article/1adfda9ed09d49c99461ba5018b477fc
Autor:
M. Gomes, A. Fleck, A. Degaugue, F. Gourmelon, C. Léger, M. Aumont-Nicaise, A. Mesneau, H. Jean-Jacques, G. Hassaine, A. Urvoas, P. Minard, M. Valerio-Lepiniec
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Scaffold-based protein libraries are designed to be both diverse and rich in functional/folded proteins. However, introducing an extended diversity while preserving stability of the initial scaffold remains a challenge. Here we developed an
Externí odkaz:
https://doaj.org/article/4bfbb5443a2448978fe944ae8711bf91
Autor:
Julia Ting Bu, Dolores Torres, Adam Robinson, Corey Malone, Juan Carlos Vera, Shadi Daghighi, Anastasie Dunn-Pirio, Suzan Khoromi, Justin Nowell, Gabriel C. Léger, Joseph D. Ciacci, Vanessa S. Goodwill, Melanie Estrella, David G. Coughlin, Yueyang Guo, Nikdokht Farid
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Neuronal intranuclear inclusion disease (NIID), a neurodegenerative disease previously thought to be rare, is increasingly recognized despite heterogeneous clinical presentations. NIID is pathologically characterized by ubiquitin and p-62 positive in
Externí odkaz:
https://doaj.org/article/77c025534afb48718ca78af0976c0b92
Autor:
Léo Varnet, Agnès C. Léger, Sophie Boucher, Crystel Bonnet, Christine Petit, Christian Lorenzi
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
The decline of speech intelligibility in presbycusis can be regarded as resulting from the combined contribution of two main groups of factors: (1) audibility-related factors and (2) age-related factors. In particular, there is now an abundant scient
Externí odkaz:
https://doaj.org/article/fbb9a160d12d492fb713d905506c2230
Publikováno v:
Ergonomics. :1-18
This cross-sectional study examined the biomechanical effects of two active chairs (AC1: had the feature to pedal and slide forward on the seat pan; AC2: a multiaxial motion seat pan) compared to a traditional office chair and standing workstation. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173227d04120e781ee9a4649a369c31c
https://doi.org/10.1080/00140139.2022.2132298
https://doi.org/10.1080/00140139.2022.2132298
Akademický článek
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Autor:
Sheridan D. Chappelle, Christina Gigliotti, Gabriel C. Léger, Guerry M. Peavy, Diane M. Jacobs, Sarah J. Banks, Emily A. Little, Douglas Galasko, David P. Salmon
Publikováno v:
Alzheimer's & Dementia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db800a0293b10494726dbcd8baafec30
https://doi.org/10.1002/alz.13039
https://doi.org/10.1002/alz.13039
Autor:
Neal R. Swerdlow, Yash B. Joshi, Joyce Sprock, Jo Talledo, Juan L. Molina, Lisa Delano-Wood, Dylan Iwanaga, Juliana E. Kotz, Steven Huege, Gabriel C. Léger, Gregory A. Light
Publikováno v:
Journal of Alzheimer's disease : JAD. 91(1)
Background: The uncompetitive NMDA antagonist, memantine (MEM), enhances prepulse inhibition of startle (PPI) across species. MEM is used to treat Alzheimer’s disease (AD); conceivably, its acute impact on PPI might be used to predict a patient’s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb1166f4cc1a2eba8bd172f71db6443
https://pubmed.ncbi.nlm.nih.gov/36404550
https://pubmed.ncbi.nlm.nih.gov/36404550
Akademický článek
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Autor:
M. Vion, G. Renard, C. Barbillon, V. Courtel, C. Léger, P. Verleye, S. Rodier, A. Fauchon, C. Dupuis
Publikováno v:
Le Pharmacien Hospitalier et Clinicien. 55:136-142
Resume Introduction Pour la semaine de la securite des patients (SSP) 2018, axee sur les erreurs medicamenteuses (EM), notre etablissement a souhaite developper un outil de simulation en sante innovant, ludique et pragmatique. L’objectif etait de c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c335f72c6934f425f1bbe1c7758c524a
https://doi.org/10.1016/j.phclin.2019.11.001
https://doi.org/10.1016/j.phclin.2019.11.001