Zobrazeno 1 - 10
of 524
pro vyhledávání: '"C, Kind"'
Autor:
Laura Simões de Oliveira, Heather E. O’Leary, Sarfaraz Nawaz, Rita Loureiro, Elizabeth C. Davenport, Paul Baxter, Susana R. Louros, Owen Dando, Emma Perkins, Julien Peltier, Matthias Trost, Emily K. Osterweil, Giles E. Hardingham, Michael A. Cousin, Sumantra Chattarji, Sam A. Booker, Tim A. Benke, David J. A Wyllie, Peter C. Kind
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Background Mutations in the X-linked gene cyclin-dependent kinase-like 5 (CDKL5) cause a severe neurological disorder characterised by early-onset epileptic seizures, autism and intellectual disability (ID). Impaired hippocampal function has
Externí odkaz:
https://doaj.org/article/ae255dae432e41748c4459655b5be30f
Autor:
PA Crisinel, P Paioni, N Müller, A Anagnostopoulos, M Hoffmann, Huldrych Günthard, J Böni, J Schüpbach, M Baumann, D Nadal, Christoph Rudin, M Egger, C-A Siegrist, N Wagner, J Németh, A Duppenthaler, J Notter, L Kaiser, J-J CHESEAUX, P Schmid, A Rauch, M Huber, C Rudin, B Ledergerber, A Calmy, M Cavassini, M Rickenbach, H Furrer, M Battegay, L Elzi, Andri Rauch, B Hirschel, E Bernasconi, HC Bucher, J Fehr, J Fellay, CA Fux, D Haerry, B Hasse, HH Hirsch, I Hösli, O Keiser, T Klimkait, H Kovari, B Martinez de Tejada, G Pantaleo, R Speck, P Tarr, A Trkola, S Yerly, P Francioli, Andrea Duppenthaler, Karoline Aebi-Popp, Noemie Wagner, Paolo Paioni, Murezi Capaul, Anja Brunner, Anna Traytel, Pierre-Alex Crisinel, Begona Martinez De Tejada, Lisa Kottanattu, Marcel Stöckle, Irene Hösli, Alexandra Scherrer, Katharina Kusejko, Christian R Kahlert, I Abela, K Aebi-Popp, DL Braun, A Ciuffi, K Darling, G Dollenmaier, K Francini, HF Günthard, A Hachfeld, D Jackson-Perry, CR Kahlert, E Kapfhammer, M Kohns, L Kottanattu, RD Kouyos, K Kusejko, N Labhardt, C Marzolini, KJ Metzner, D Nicca, M Perreau, Polli Ch, L Salazar-Vizcaya, M Stöckle, M Thanh Lecompte, G Wandeler, M Weisser, C Kind
Publikováno v:
BMJ Open, Vol 14, Iss 9 (2024)
Purpose Prospective, multicentric observational cohort study in Switzerland investigating measures to prevent mother-to-child transmission in pregnant women with HIV (WWH) and assessing health and development of their exposed children as well as of c
Externí odkaz:
https://doaj.org/article/141a8a7fc8fb4df38900406381bf05e0
Autor:
Owen Dando, Jamie McQueen, Karen Burr, Peter C. Kind, Siddharthan Chandran, Giles E. Hardingham, Jing Qiu
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Rodent studies have shown that alternative splicing in neurons plays important roles in development and maturity, and is regulatable by signals such as electrical activity. However, rodent-human similarities are less well explored. We compared basal
Externí odkaz:
https://doaj.org/article/ce260b833ff24902a5ce953b3917db8a
Publikováno v:
Frontiers in Systems Neuroscience, Vol 17 (2023)
Cerebellar networks have traditionally been linked to sensorimotor control. However, a large body of evidence suggests that cerebellar functions extend to non-motor realms, such as fear-based emotional processing and that these functions are supporte
Externí odkaz:
https://doaj.org/article/fc3dc02dc44d4dc4b108e9cd2f4d1769
Autor:
Yifei Yang, Sam A. Booker, James M. Clegg, Idoia Quintana-Urzainqui, Anna Sumera, Zrinko Kozic, Owen Dando, Sandra Martin Lorenzo, Yann Herault, Peter C. Kind, David J. Price, Thomas Pratt
Publikováno v:
BMC Neuroscience, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Background Autism spectrum condition or ‘autism’ is associated with numerous genetic risk factors including the polygenic 16p11.2 microdeletion. The balance between excitatory and inhibitory neurons in the cerebral cortex is hypothesised
Externí odkaz:
https://doaj.org/article/94e25852ab114ae8b3fe8bb4a3c913b2
Autor:
Antonis Asiminas, Sam A. Booker, Owen R. Dando, Zrinko Kozic, Daisy Arkell, Felicity H. Inkpen, Anna Sumera, Irem Akyel, Peter C. Kind, Emma R. Wood
Publikováno v:
Molecular Autism, Vol 13, Iss 1, Pp 1-29 (2022)
Abstract Background Fragile X syndrome (FXS) is a common single gene cause of intellectual disability and autism spectrum disorder. Cognitive inflexibility is one of the hallmarks of FXS with affected individuals showing extreme difficulty adapting t
Externí odkaz:
https://doaj.org/article/e0dabc1eced84dd8ab6b7b80f7f03aae
Autor:
Natasha J. Anstey, Vijayakumar Kapgal, Shashank Tiwari, Thomas C. Watson, Anna K. H. Toft, Owen R. Dando, Felicity H. Inkpen, Paul S. Baxter, Zrinko Kozić, Adam D. Jackson, Xin He, Mohammad Sarfaraz Nawaz, Aiman Kayenaat, Aditi Bhattacharya, David J. A. Wyllie, Sumantra Chattarji, Emma R. Wood, Oliver Hardt, Peter C. Kind
Publikováno v:
Molecular Autism, Vol 13, Iss 1, Pp 1-19 (2022)
Abstract Background Mutations in the postsynaptic transmembrane protein neuroligin-3 are highly correlative with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Fear learning is well studied in models of these disorders, however
Externí odkaz:
https://doaj.org/article/3d9e90cbc8e047a6a47ce223c07a8fd8
Autor:
Shreya Das Sharma, Bharath Kumar Reddy, Rakhi Pal, Tuula E. Ritakari, James D. Cooper, Bhuvaneish T. Selvaraj, Peter C. Kind, Siddharthan Chandran, David J.A. Wyllie, Sumantra Chattarji
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112344- (2023)
Summary: Pre-clinical studies of fragile X syndrome (FXS) have focused on neurons, with the role of glia remaining largely underexplored. We examined the astrocytic regulation of aberrant firing of FXS neurons derived from human pluripotent stem cell
Externí odkaz:
https://doaj.org/article/07393c8817104f9e9f38c64e50f84baa
Autor:
Sang S. Seo, Susana R. Louros, Natasha Anstey, Miguel A. Gonzalez-Lozano, Callista B. Harper, Nicholas C. Verity, Owen Dando, Sophie R. Thomson, Jennifer C. Darnell, Peter C. Kind, Ka Wan Li, Emily K. Osterweil
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Dysregulated protein synthesis is key contributor to Fragile X syndrome. Here the authors identify a relationship between ribosome expression and the translation of long mRNAs that contributes to synaptic weakening in a model of Fragile X syndrome.
Externí odkaz:
https://doaj.org/article/8ae6ea90e044406685e3c0bd724e960e
Autor:
Zoeb Jiwaji, Sachin S. Tiwari, Rolando X. Avilés-Reyes, Monique Hooley, David Hampton, Megan Torvell, Delinda A. Johnson, Jamie McQueen, Paul Baxter, Kayalvizhi Sabari-Sankar, Jing Qiu, Xin He, Jill Fowler, James Febery, Jenna Gregory, Jamie Rose, Jane Tulloch, Jamie Loan, David Story, Karina McDade, Amy M. Smith, Peta Greer, Matthew Ball, Peter C. Kind, Paul M. Matthews, Colin Smith, Owen Dando, Tara L. Spires-Jones, Jeffrey A. Johnson, Siddharthan Chandran, Giles E. Hardingham
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Alzheimer’s disease is associated with changes in astrocytes. Here the authors investigated the astrocyte translatome associated with amyloid-ß and tau pathology.
Externí odkaz:
https://doaj.org/article/3684566e972d48bda37be69378c00e42