Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV)

Autor: PA Crisinel, P Paioni, N Müller, A Anagnostopoulos, M Hoffmann, Huldrych Günthard, J Böni, J Schüpbach, M Baumann, D Nadal, Christoph Rudin, M Egger, C-A Siegrist, N Wagner, J Németh, A Duppenthaler, J Notter, L Kaiser, J-J CHESEAUX, P Schmid, A Rauch, M Huber, C Rudin, B Ledergerber, A Calmy, M Cavassini, M Rickenbach, H Furrer, M Battegay, L Elzi, Andri Rauch, B Hirschel, E Bernasconi, HC Bucher, J Fehr, J Fellay, CA Fux, D Haerry, B Hasse, HH Hirsch, I Hösli, O Keiser, T Klimkait, H Kovari, B Martinez de Tejada, G Pantaleo, R Speck, P Tarr, A Trkola, S Yerly, P Francioli, Andrea Duppenthaler, Karoline Aebi-Popp, Noemie Wagner, Paolo Paioni, Murezi Capaul, Anja Brunner, Anna Traytel, Pierre-Alex Crisinel, Begona Martinez De Tejada, Lisa Kottanattu, Marcel Stöckle, Irene Hösli, Alexandra Scherrer, Katharina Kusejko, Christian R Kahlert, I Abela, K Aebi-Popp, DL Braun, A Ciuffi, K Darling, G Dollenmaier, K Francini, HF Günthard, A Hachfeld, D Jackson-Perry, CR Kahlert, E Kapfhammer, M Kohns, L Kottanattu, RD Kouyos, K Kusejko, N Labhardt, C Marzolini, KJ Metzner, D Nicca, M Perreau, Polli Ch, L Salazar-Vizcaya, M Stöckle, M Thanh Lecompte, G Wandeler, M Weisser, C Kind

Publikováno v: BMJ Open, Vol 14, Iss 9 (2024)

Purpose Prospective, multicentric observational cohort study in Switzerland investigating measures to prevent mother-to-child transmission in pregnant women with HIV (WWH) and assessing health and development of their exposed children as well as of c

Externí odkaz: https://doaj.org/article/141a8a7fc8fb4df38900406381bf05e0

Cerebellar contributions to fear-based emotional processing: relevance to understanding the neural circuits involved in autism

Autor: Sabina Couto-Ovejero, Jingjing Ye, Peter C. Kind, Sally M. Till, Thomas C. Watson

Publikováno v: Frontiers in Systems Neuroscience, Vol 17 (2023)

Cerebellar networks have traditionally been linked to sensorimotor control. However, a large body of evidence suggests that cerebellar functions extend to non-motor realms, such as fear-based emotional processing and that these functions are supporte

Externí odkaz: https://doaj.org/article/fc3dc02dc44d4dc4b108e9cd2f4d1769

Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome

Autor: Antonis Asiminas, Sam A. Booker, Owen R. Dando, Zrinko Kozic, Daisy Arkell, Felicity H. Inkpen, Anna Sumera, Irem Akyel, Peter C. Kind, Emma R. Wood

Publikováno v: Molecular Autism, Vol 13, Iss 1, Pp 1-29 (2022)

Abstract Background Fragile X syndrome (FXS) is a common single gene cause of intellectual disability and autism spectrum disorder. Cognitive inflexibility is one of the hallmarks of FXS with affected individuals showing extreme difficulty adapting t

Externí odkaz: https://doaj.org/article/e0dabc1eced84dd8ab6b7b80f7f03aae

Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome

Autor: Sang S. Seo, Susana R. Louros, Natasha Anstey, Miguel A. Gonzalez-Lozano, Callista B. Harper, Nicholas C. Verity, Owen Dando, Sophie R. Thomson, Jennifer C. Darnell, Peter C. Kind, Ka Wan Li, Emily K. Osterweil

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Dysregulated protein synthesis is key contributor to Fragile X syndrome. Here the authors identify a relationship between ribosome expression and the translation of long mRNAs that contributes to synaptic weakening in a model of Fragile X syndrome.

Externí odkaz: https://doaj.org/article/8ae6ea90e044406685e3c0bd724e960e

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

Autor: Zoeb Jiwaji, Sachin S. Tiwari, Rolando X. Avilés-Reyes, Monique Hooley, David Hampton, Megan Torvell, Delinda A. Johnson, Jamie McQueen, Paul Baxter, Kayalvizhi Sabari-Sankar, Jing Qiu, Xin He, Jill Fowler, James Febery, Jenna Gregory, Jamie Rose, Jane Tulloch, Jamie Loan, David Story, Karina McDade, Amy M. Smith, Peta Greer, Matthew Ball, Peter C. Kind, Paul M. Matthews, Colin Smith, Owen Dando, Tara L. Spires-Jones, Jeffrey A. Johnson, Siddharthan Chandran, Giles E. Hardingham

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)

Alzheimer’s disease is associated with changes in astrocytes. Here the authors investigated the astrocyte translatome associated with amyloid-ß and tau pathology.

Externí odkaz: https://doaj.org/article/3684566e972d48bda37be69378c00e42