Zobrazeno 1 - 10
of 3 960
pro vyhledávání: '"C, Keen"'
Autor:
Alastair C. Keen, Maria Hauge Pedersen, Laura Lemel, Daniel J. Scott, Meritxell Canals, Dene R. Littler, Travis Beddoe, Yuki Ono, Lei Shi, Asuka Inoue, Jonathan A. Javitch, J. Robert Lane
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
A recently identified pertussis toxin-like AB5 toxin, OZITX, is found to inhibit Gαi/o and Gαz G proteins. In combination with directed mutations, it is a useful tool for interrogating Gαi/o/z G protein subunits individually.
Externí odkaz:
https://doaj.org/article/ac065c0033244eb3932a5b3f91103777
Autor:
Anika Mann, Alastair C. Keen, Hanka Mark, Pooja Dasgupta, Jonathan A. Javitch, Meritxell Canals, Stefan Schulz, J. Robert Lane
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The dopamine D2 receptor (D2R) is the target of drugs used to treat the symptoms of Parkinson’s disease and schizophrenia. The D2R is regulated through its interaction with and phosphorylation by G protein receptor kinases (GRKs) and inter
Externí odkaz:
https://doaj.org/article/ca749480bcc9489bb045eb4ed1f42bf3
Autor:
Eric C. Keen, JooHee Choi, Meghan A. Wallace, Michelle Azar, Carlos R. Mejia-Chew, Shail B. Mehta, Thomas C. Bailey, Lindsay J. Caverly, Carey-Ann D. Burnham, Gautam Dantas
Publikováno v:
mSystems, Vol 6, Iss 5 (2021)
ABSTRACT Nontuberculous mycobacteria, including those in the Mycobacterium avium complex (MAC), constitute an increasingly urgent threat to global public health. Ubiquitous in soil and water worldwide, MAC members cause a diverse array of infections
Externí odkaz:
https://doaj.org/article/8033b0c504ae4f659ef2ce119f3789a1
Autor:
Maxine J. Roberts, Lauren T. May, Alastair C. Keen, Bonan Liu, Terrance Lam, Steven J. Charlton, Elizabeth M. Rosethorne, Michelle L. Halls
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Idiopathic pulmonary fibrosis is a chronic and progressive fibrotic lung disease, and current treatments are limited by their side effects. Proliferation of human lung fibroblasts in the pulmonary interstitial tissue is a hallmark of this disease and
Externí odkaz:
https://doaj.org/article/5c85396c76d64dc79fc084910f1ff65a
Autor:
J Robert Lane, Ara M Abramyan, Pramisha Adhikari, Alastair C Keen, Kuo-Hao Lee, Julie Sanchez, Ravi Kumar Verma, Herman D Lim, Hideaki Yano, Jonathan A Javitch, Lei Shi
Publikováno v:
eLife, Vol 9 (2020)
By analyzing and simulating inactive conformations of the highly homologous dopamine D2 and D3 receptors (D2R and D3R), we find that eticlopride binds D2R in a pose very similar to that in the D3R/eticlopride structure but incompatible with the D2R/r
Externí odkaz:
https://doaj.org/article/22ae5702392642ec91760a357236acbd
Autor:
Paul Leary
Publikováno v:
Geological Journal. 26:186-187
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac349f1f77bc4c55a580ab9cc2fce221
https://doi.org/10.1002/gj.3350260211
https://doi.org/10.1002/gj.3350260211
Autor:
Yong-Gang Chang, Christopher J. Lupton, Charles Bayly-Jones, Alastair C. Keen, Laura D’Andrea, Christina M. Lucato, Joel R. Steele, Hari Venugopal, Ralf B. Schittenhelm, James C. Whisstock, Michelle L. Halls, Andrew M. Ellisdon
Publikováno v:
Nature Structural & Molecular Biology. 29:767-773
P-Rex (PI(3,4,5)P3-dependent Rac exchanger) guanine nucleotide exchange factors potently activate Rho GTPases. P-Rex guanine nucleotide exchange factors are autoinhibited, synergistically activated by Gβγ and PI(3,4,5)P3 binding and dysregulated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4933da63b86a93b7d7d691f3041d1107
https://doi.org/10.1038/s41594-022-00804-9
https://doi.org/10.1038/s41594-022-00804-9
Autor:
JooHee Choi, Eric C Keen, Meghan A Wallace, Skye Fishbein, Jerome Prusa, Madsen Zimbric, Carlos R Mejia-Chew, Shail B Mehta, Thomas C Bailey, Lindsay J Caverly, Carey-Ann D Burnham, Gautam Dantas
Publikováno v:
The Journal of Infectious Diseases.
Background Nontuberculous mycobacteria (NTM) are ubiquitous in the environment and an increasingly frequent cause of opportunistic infections. Mycobacterium abscessus complex (MAB) is one of the major NTM lung pathogens which disproportionately colon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::222e9c014439537b7debc565310ff291
https://doi.org/10.1093/infdis/jiad187
https://doi.org/10.1093/infdis/jiad187
Autor:
P.W. Jones, L. Belton, P.-R. Burgel, R. Hughes, C. Keen Fredriksson, B.J. Make, H. Müllerová, A. Papi, H.K. Reddel, E.L. Tomaszewski, null NOVELTY Scientific Community, null NOVELTY study investigators
Publikováno v:
B31. ASTHMA: FROM MICE TO MEN, AND BACK AGAIN.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3887839e79c767485f952fb2e75bae5d
https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3042
https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3042
Autor:
P.W. Jones, L. Belton, P.-R. Burgel, R. Hughes, C. Keen Fredriksson, B.J. Make, H. Müllerová, A. Papi, H.K. Reddel, E.L. Tomaszewski, null NOVELTY Scientific Community, null NOVELTY study investigators
Publikováno v:
B31. ASTHMA: FROM MICE TO MEN, AND BACK AGAIN.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6869e0a00f24cd468d3e0247d5a912c0
https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3043
https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3043