Zobrazeno 1 - 10
of 1 249
pro vyhledávání: '"C, Irwin"'
Autor:
Tomiko T. Oskotsky, Arohee Bhoja, Daniel Bunis, Brian L. Le, Alice S. Tang, Idit Kosti, Christine Li, Sahar Houshdaran, Sushmita Sen, Júlia Vallvé-Juanico, Wanxin Wang, Erin Arthurs, Arpita Govil, Lauren Mahoney, Lindsey Lang, Brice Gaudilliere, David K. Stevenson, Juan C. Irwin, Linda C. Giudice, Stacy L. McAllister, Marina Sirota
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109388- (2024)
Summary: Existing medical treatments for endometriosis-related pain are often ineffective, underscoring the need for new therapeutic strategies. In this study, we applied a computational drug repurposing pipeline to stratified and unstratified diseas
Externí odkaz:
https://doaj.org/article/7cb7fa771de148cfb0ba716157579323
Autor:
Christina Lisk, Alex Fan, Francesca I. Cendali, Kenta Kakiuchi, Delaney Swindle, David I. Pak, Robert Tolson, Abby Grier, Keely Buesing, Seth Zaeske, Angelo D’Alessandro, Mark A. Borden, David C. Irwin
Publikováno v:
Bioengineering, Vol 11, Iss 8, p 761 (2024)
Administration of oxygen microbubbles (OMBs) has been shown to increase oxygen and decrease carbon dioxide in systemic circulation, as well as reduce lung inflammation and promote survival in preclinical models of hypoxia caused by lung injury. Howev
Externí odkaz:
https://doaj.org/article/ee6335072f5c4bf5be797180156f93b1
Autor:
Sally Mortlock, Sahar Houshdaran, Idit Kosti, Nilufer Rahmioglu, Camran Nezhat, Allison F. Vitonis, Shan V. Andrews, Parker Grosjean, Manish Paranjpe, Andrew W. Horne, Alison Jacoby, Jeannette Lager, Jessica Opoku-Anane, Kim Chi Vo, Evelina Manvelyan, Sushmita Sen, Zhanna Ghukasyan, Frances Collins, Xavier Santamaria, Philippa Saunders, Kord Kober, Allan F. McRae, Kathryn L. Terry, Júlia Vallvé-Juanico, Christian Becker, Peter A. W. Rogers, Juan C. Irwin, Krina Zondervan, Grant W. Montgomery, Stacey Missmer, Marina Sirota, Linda Giudice
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Endometriosis is a leading cause of pain and infertility affecting millions of women globally. Herein, we characterize variation in DNA methylation (DNAm) and its association with menstrual cycle phase, endometriosis, and genetic variants th
Externí odkaz:
https://doaj.org/article/f61d2545020c46a2baff0d24cc8d121a
Autor:
Kiruphagaran Thangaraju PhD, Saini Setua PhD, Christina Lisk PhD, Delaney Swindle MS, Daniel Stephenson PhD, Monika Dzieciatkowska PhD, Derek R. Lamb BS, Parikshit Moitra PhD, David Pak MS, Kathryn Hassell MD, Gemlyn George MD, Rachelle Nuss MD, Pavel Davizon-Castillo MD, Kurt R. Stenmark MD, Angelo D’Alessandro PhD, David C. Irwin PhD, Paul W. Buehler PharmD, PhD
Publikováno v:
Clinical and Applied Thrombosis/Hemostasis, Vol 29 (2023)
Aberrant coagulation in sickle cell disease (SCD) is linked to extracellular vesicle (EV) exposure. However, there is no consensus on the contributions of small EVs (SEVs) and large EVs (LEVs) toward underlying coagulopathy or on their molecular carg
Externí odkaz:
https://doaj.org/article/4769d021364e45e397107d74814a04a5
Autor:
Christina Lisk, Francesca Cendali, David I. Pak, Delaney Swindle, Kathryn Hassell, Rachelle Nuss, Gemlyn George, Pavel Davizon-Castillo, Paul W. Buehler, Angelo D’Alessandro, David C. Irwin
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionHuman and murine sickle cell disease (SCD) associated pulmonary hypertension (PH) is defined by hemolysis, nitric oxide depletion, inflammation, and thrombosis. Further, hemoglobin (Hb), heme, and iron accumulation are consistently observ
Externí odkaz:
https://doaj.org/article/2b14caf86c4044b991f1322159efd216
Autor:
Júlia Vallvé-Juanico, Ashley F. George, Sushmita Sen, Reuben Thomas, Min-Gyoung Shin, Divyashree Kushnoor, Joshua J. Vásquez, Kim Chi Vo, Juan C. Irwin, Nadia R. Roan, Alexis J. Combes, Linda C. Giudice
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-19 (2022)
Abstract Background Endometriosis is a chronic, estrogen-dependent disorder where inflammation contributes to disease-associated symptoms of pelvic pain and infertility. Immune dysfunction includes insufficient immune lesion clearance, a pro-inflamma
Externí odkaz:
https://doaj.org/article/3b2c8697a1e145c18977060f000edef6
Autor:
Paul W. Buehler, Delaney Swindle, David I. Pak, Mehdi A. Fini, Kathryn Hassell, Rachelle Nuss, Rebecca B. Wilkerson, Angelo D’Alessandro, David C. Irwin
Publikováno v:
Pulmonary Circulation, Vol 11, Iss 4, Pp 1-12 (2021)
Sickle cell anemia and β‐thalassemia intermedia are very different genetically determined hemoglobinopathies predisposing to pulmonary hypertension. The etiologies responsible for the associated development of pulmonary hypertension in both diseas
Externí odkaz:
https://doaj.org/article/a6772f4e041245f38a3c7f1237ddb78b
Autor:
Vijaya Karoor, Delaney Swindle, David I Pak, Julie Harral, Derek Strassheim, Mehdi A Fini, Edward Dempsey, Kurt R Stenmark, Kathryn Hassell, Rachelle Nuss, Paul W. Buehler, David C. Irwin
Publikováno v:
Pulmonary Circulation, Vol 11, Iss 4, Pp 1-11 (2021)
Macrophages are a heterogeneous population with both pro‐ and anti‐inflammatory functions play an essential role in maintaining tissue homeostasis, promoting inflammation under pathological conditions, and tissue repair after injury. In pulmonary
Externí odkaz:
https://doaj.org/article/120e16e92c14421486d903082b393f81
Autor:
Daniel G. Bunis, Wanxin Wang, Júlia Vallvé-Juanico, Sahar Houshdaran, Sushmita Sen, Isam Ben Soltane, Idit Kosti, Kim Chi Vo, Juan C. Irwin, Linda C. Giudice, Marina Sirota
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
The uterine lining (endometrium) exhibits a pro-inflammatory phenotype in women with endometriosis, resulting in pain, infertility, and poor pregnancy outcomes. The full complement of cell types contributing to this phenotype has yet to be identified
Externí odkaz:
https://doaj.org/article/4733fe4718cf4973b6070d00bd323c92