Zobrazeno 1 - 10
of 107
pro vyhledávání: '"C, Huebert"'
Autor:
Philipp Felgendreff, Seyed Mohammad Hosseiniasl, Anna Minshew, Bruce P. Amiot, Silvana Wilken, Boyukkhanim Ahmadzada, Robert C. Huebert, Nidhi Jalan Sakrikar, Noah G. Engles, Peggy Halsten, Kendra Mariakis, John Barry, Shawn Riesgraf, Chris Fecteau, Jeffrey J. Ross, Scott L. Nyberg
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1272 (2024)
In this study, a mixed porcine–human bioengineered liver (MPH-BEL) was used in a preclinical setup of extracorporeal liver support devices as a treatment for a model of post-resection liver failure (PRLF). The potential for human clinical applicati
Externí odkaz:
https://doaj.org/article/09ed58633aeb4bbf931d90a7f38ea04d
Autor:
Nidhi Jalan-Sakrikar, Abid Anwar, Usman Yaqoob, Can Gan, Anthony B. Lagnado, Alexander Q. Wixom, Diana Jurk, Robert C. Huebert
Publikováno v:
JCI Insight, Vol 8, Iss 20 (2023)
Cellular senescence and biliary fibrosis are prototypical features of obliterative cholangiopathies, such as primary sclerosing cholangitis (PSC). Telomere dysfunction can lead to senescence either through telomere erosion or damaged telomeres. Our g
Externí odkaz:
https://doaj.org/article/3bb8d0fb2fe74071a92357a1385ba71e
Autor:
Samuel C. Buchl, Zachary Hanquier, Andrew J. Haak, Yvonne M. Thomason, Robert C. Huebert, Vijay H. Shah, Jessica L. Maiers
Publikováno v:
Hepatology Communications, Vol 6, Iss 3, Pp 593-609 (2022)
Hepatic fibrosis is driven by deposition of matrix proteins following liver injury. Hepatic stellate cells (HSCs) drive fibrogenesis, producing matrix proteins, including procollagen I, which matures into collagen I following secretion. Disrupting in
Externí odkaz:
https://doaj.org/article/bcafa6911f9b4aaba6a84b3f78a8b036
Autor:
Nidhi Jalan‐Sakrikar, Thiago M. De Assuncao, Amaia Navarro‐Corcuera, Feda H. Hamdan, Lorena Loarca, Lindsey A. Kirkeby, Zachary T. Resch, Steven P. O’Hara, Brian D. Juran, Konstantinos N. Lazaridis, Charles B. Rosen, Julie K. Heimbach, Timucin Taner, Vijay H. Shah, Nicholas F. LaRusso, Robert C. Huebert
Publikováno v:
Hepatology Communications, Vol 6, Iss 2, Pp 345-360 (2022)
Primary sclerosing cholangitis (PSC) is a chronic fibroinflammatory disease of the biliary tract characterized by cellular senescence and periportal fibrogenesis. Specific disease features that are cell intrinsic and either genetically or epigenetica
Externí odkaz:
https://doaj.org/article/ca9f01c370f541249f03d813d0b08950
Autor:
Seyed M. Hosseiniasl, Philipp Felgendreff, Mohammad Tharwat, Bruce Amiot, Anan AbuRmilah, Anna M. Minshew, Alexander M. Bornschlegl, Nidhi Jalan-Sakrikar, Michele Smart, Allan B. Dietz, Robert C. Huebert, Scott L. Nyberg
Publikováno v:
Cytotherapy. 25:483-489
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ae4b2415d31482705e49bb7c4768280
https://doi.org/10.1016/j.jcyt.2023.01.014
https://doi.org/10.1016/j.jcyt.2023.01.014
Autor:
Rosa Martin-Mateos, Thiago M. De Assuncao, Juan Pablo Arab, Nidhi Jalan-Sakrikar, Usman Yaqoob, Thomas Greuter, Vikas K. Verma, Angela J. Mathison, Sheng Cao, Gwen Lomberk, Philippe Mathurin, Raul Urrutia, Robert C. Huebert, Vijay H. Shah
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 197-209 (2019)
Background & Aims: Transdifferentiation of hepatic stellate cells (HSCs) into myofibroblasts is a key event in the pathogenesis of liver fibrosis. Transforming growth factor β (TGF-β) and platelet-derived growth factor (PDGF) are canonical HSC acti
Externí odkaz:
https://doaj.org/article/92c272812afb470fade61825b1e16415
Autor:
Amaia Navarro-Corcuera, Tejasav S. Sehrawat, Nidhi Jalan-Sakrikar, Hunter R. Gibbons, Nicholas E. Pirius, Shalil Khanal, Feda H. Hamdan, Sayed Obaidullah Aseem, Sheng Cao, Jesus M. Banales, Ningling Kang, William A. Faubion, Nicholas F. LaRusso, Vijay H. Shah, Robert C. Huebert
Publikováno v:
J Hepatol
BACKGROUND AND AIMS: Biliary disease is associated with a proliferative/fibrogenic ductular reaction (DR). p300 is an epigenetic regulator that acetylates lysine 27 on histone 3 (H3K27ac) and is activated during fibrosis. Long non-coding RNAs (lncRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96bef0dc509c86116f00a0bcf788e73e
https://doi.org/10.1016/j.jhep.2021.12.014
https://doi.org/10.1016/j.jhep.2021.12.014
Publikováno v:
Mayo Clinic Proceedings. 97:795-800
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4365c9c1fc794813ab0752a5bb57fa7e
https://doi.org/10.1016/j.mayocp.2021.09.023
https://doi.org/10.1016/j.mayocp.2021.09.023
Autor:
Konstantinos N. Lazaridis, Amaia Navarro-Corcuera, Julie K. Heimbach, Lindsey A Kirkeby, Robert C. Huebert, Thiago M. De Assuncao, Charles B. Rosen, Nidhi Jalan-Sakrikar, Brian D. Juran, Feda H. Hamdan, Vijay H. Shah, Steven P. O'Hara, Lorena Loarca, Zachary T. Resch, Timucin Taner, Nicholas F. LaRusso
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 6, Iss 2, Pp 345-360 (2022)
Hepatology Communications, Vol 6, Iss 2, Pp 345-360 (2022)
Primary sclerosing cholangitis (PSC) is a chronic fibroinflammatory disease of the biliary tract characterized by cellular senescence and periportal fibrogenesis. Specific disease features that are cell intrinsic and either genetically or epigenetica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961435e3b5b3f5992ed71dbf8eacd11e
http://europepmc.org/articles/PMC8793999
http://europepmc.org/articles/PMC8793999
Autor:
Christen J. Boyer, Moheb Boktor, Hrishikesh Samant, Luke A. White, Yuping Wang, David H. Ballard, Robert C. Huebert, Jennifer E. Woerner, Ghali E. Ghali, Jonathan S. Alexander
Publikováno v:
Bioengineering, Vol 6, Iss 1, p 16 (2019)
Three-dimensional (3D) printing is an additive manufacturing method that holds great potential in a variety of future patient-specific medical technologies. This project validated a novel crosslinked polyvinyl alcohol (XL-PVA) 3D printed stent infuse
Externí odkaz:
https://doaj.org/article/d640a8c313ae49e29c60aeace0c95a60