Zobrazeno 1 - 10 of 71 pro vyhledávání: '"C, Hubeau"'
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POS0479 STAT3 DEGRADERS PROTECT FROM IMMUNOFIBROTIC CHANGES IN PRECLINICAL MODELS
Autor: P. Blyszczuk, G. Kania, E. Pachera, F. Rolski, A. Hukara, V. Tela, M. Mayo, V. Dixit, B. Yang, J. Gollob, N. Mainolfi, A. Slavin, C. Hubeau, O. Distler
Publikováno v: Annals of the Rheumatic Diseases. 81:494-495
BackgroundThe ubiquitin-proteasome system (UPS) is the endogenous intracellular mechanism for maintaining protein homeostasis through protein degradation and turnover. Heterobifunctional small molecules are a new class of compounds that form a ternar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcc4a7b7f2f55718eaa786be77a74d57
https://doi.org/10.1136/annrheumdis-2022-eular.2573
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2
OP0080 STAT3 DEGRADERS INHIBIT Th17 DEVELOPMENT AND CYTOKINE PRODUCTION RESULTING IN PROFOUND INHIBITION OF COLLAGEN-INDUCED AUTOIMMUNE MURINE ARTHRITIS
Autor: C. Hubeau, J. Sullivan, C. Brown, M. Mayo, V. Dixit, B. Enerson, H. Rong, B. Yang, C. De Savi, J. Gollob, N. Mainolfi, A. Slavin
Publikováno v: Annals of the Rheumatic Diseases. 81:54.1-54
BackgroundSignal transducer and activator of transcription 3 (STAT3) is a transcription factor that belongs to a class of targets devoid of catalytic function, thus deemed “undruggable” by standard modalities such as small molecule inhibitors or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0978a1b5692bf8c548979a6b572d3d50
https://doi.org/10.1136/annrheumdis-2022-eular.2068
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3
Akademický článek
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4
OP0316 EMERGING BEST-IN-CLASS IL-2 VARIANT HIGHLIGHTS TREG-DIRECTED THERAPY FOR AUTOIMMUNE DISEASE
Autor: B. Capraro, S. Frei, C. Hubeau, J. Xu, A. Umana, L. Rui, V. Massa, A. Aherrera, W. Li, Y. Li, Y. T. Hsieh
Publikováno v: Annals of the Rheumatic Diseases. 79:195.1-195
Background:Impairment or deficiency of regulatory T cells (Treg) is associated with chronic inflammation and autoimmune diseases. Interleukin 2 (IL-2) is a cytokine indispensable for Treg expansion and immunosuppressive function. However, expansion o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ac7e9a2c62d611efd6f8d394cf9f067
https://doi.org/10.1136/annrheumdis-2020-eular.1999
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5
Akademický článek
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6
Extended freeze-dried Mycobacterium bovis Bacillus Calmette-Guérin induces the release of interleukin-12 but not tumour necrosis factor-α by alveolar macrophages, both in vitro and in vivo
Autor: M. Singer, B. Boris Vargaftig, C. Hubeau, Micheline Lagranderie, G. Marchal
Publikováno v: Clinical & Experimental Allergy. 33:386-393
Summary Background Airway hyper-responsiveness (AHR), chronic airway inflammation and predominance of the T helper type-2 (Th2; IL-4, IL-5, IL-13) over the Th1 (IL-2, IFN-γ) immune response are hallmarks of asthma. Alveolar macrophages (AM) are the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fb4286155d6b4225cdccf9a44f635ba
https://doi.org/10.1046/j.1365-2222.2003.01612.x
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7
Quantitative analysis of inflammatory cells infiltrating the cystic fibrosis airway mucosa
Autor: C. Hubeau, J. P. Couetil, D. Hubert, Dominique Gaillard, E. Puchelle, D. Dusser, M. Lorenzato
Publikováno v: Clinical and Experimental Immunology
Clinical and Experimental Immunology, Wiley, 2001, 124 (1), pp.69-76
SUMMARYAirway inflammation represents a hallmark of the cystic fibrosis (CF) disease. However, the mucosal distribution of immune cells along the CF airways has not been clearly defined, particularly in intermediate bronchi and distal bronchioles. We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82db38e5cdb3bca71f43bf6e07d8debf
https://doi.org/10.1046/j.1365-2249.2001.01456.x
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9
Dysregulation of IL-2 and IL-8 production in circulating T lymphocytes from young cystic fibrosis patients
Autor: Dominique Gaillard, C. Hubeau, R. Le Naour, Moncef Guenounou, Jocelyne Hinnrasky, M. Abely, E. Puchelle
Publikováno v: Clinical and Experimental Immunology
Clinical and Experimental Immunology, Wiley, 2004, 135 (3), pp.528-34. ⟨10.1111/j.1365-2249.2003.02385.x⟩
SUMMARY It is well documented that patients with cystic fibrosis (CF) are unable to clear persistent airway infections in spite of strong local inflammation, suggesting a dysregulation of immunity in CF. We and others have reported previously that T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62bff65ab89892b40e7ddfa18becec5
https://www.hal.inserm.fr/inserm-00145671
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10
Extended freeze-dried Mycobacterium bovis Bacillus Calmette-Guérin induces the release of interleukin-12 but not tumour necrosis factor-alpha by alveolar macrophages, both in vitro and in vivo
Autor: C, Hubeau, M, Singer, M, Lagranderie, G, Marchal, B, Vargaftig
Publikováno v: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 33(3)
Airway hyper-responsiveness (AHR), chronic airway inflammation and predominance of the T helper type-2 (Th2; IL-4, IL-5, IL-13) over the Th1 (IL-2, IFN-gamma) immune response are hallmarks of asthma. Alveolar macrophages (AM) are the most numerous ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3d8dbe7cac32dd1ecbf72b253a14d11c
https://pubmed.ncbi.nlm.nih.gov/12614454
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