Zobrazeno 1 - 10
of 765
pro vyhledávání: '"C, Hofbauer"'
Autor:
Franziska Lademann, Eddy Rijntjes, Josef Köhrle, Elena Tsourdi, Lorenz C. Hofbauer, Martina Rauner
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Hyperthyroidism is a well-known trigger of high bone turnover that can lead to the development of secondary osteoporosis. Previously, we have shown that blocking bone morphogenetic protein (BMP) signaling systemically with BMPR1A-Fc can prev
Externí odkaz:
https://doaj.org/article/8b89a9a3c6184875be917878699170d0
Autor:
Maria G. Ledesma-Colunga, Vanessa Passin, Maja Vujic Spasic, Lorenz C. Hofbauer, Ulrike Baschant, Martina Rauner
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Iron is an essential nutrient for all living organisms. Both iron deficiency and excess can be harmful. Bone, a highly metabolic active organ, is particularly sensitive to fluctuations in iron levels. In this study, we investigated the effec
Externí odkaz:
https://doaj.org/article/b2489d71ce5a4ab2901d9eeeb41f5e37
Autor:
Lejla Emini, Juliane Salbach‐Hirsch, Johannes Krug, Katharina Jähn‐Rickert, Björn Busse, Martina Rauner, Lorenz C. Hofbauer
Publikováno v:
JBMR Plus, Vol 7, Iss 12, Pp n/a-n/a (2023)
ABSTRACT Type 2 diabetes mellitus (T2DM) increases risk of fractures due to bone microstructural and material deficits, though the mechanisms remain unclear. Preclinical models mimicking diabetic bone disease are required to further understand its pa
Externí odkaz:
https://doaj.org/article/617544c3b8574c5c893e33fbc5078247
Publikováno v:
JBMR Plus, Vol 7, Iss 11, Pp n/a-n/a (2023)
ABSTRACT Bone has the fascinating ability to self‐regenerate. However, under certain conditions, such as type 2 diabetes mellitus (T2DM), this ability is impaired. T2DM is a chronic metabolic disease known by the presence of elevated blood glucose
Externí odkaz:
https://doaj.org/article/1a3670cf64634843ba93f050bf0a4764
Autor:
Nikolai P. Jaschke, Sophie Pählig, Anupam Sinha, Timon E. Adolph, Maria Ledesma Colunga, Maura Hofmann, Andrew Wang, Sylvia Thiele, Julian Schwärzler, Alexander Kleymann, Marc Gentzel, Herbert Tilg, Ben Wielockx, Lorenz C. Hofbauer, Martina Rauner, Andy Göbel, Tilman D. Rachner
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
A combination of cell line, transgenic mouse and human genetic data implicates a proinflammatory function of Dickkopf1 across malignant and non-malignant cells.
Externí odkaz:
https://doaj.org/article/08ca554bb4284badb614763c54f2ed47
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Osteocytes are specialized bone cells that orchestrate skeletal remodeling. Senescent osteocytes are characterized by an activation of cyclin-dependent kinase inhibitor p16Ink4a and have been implicated in the pathogenesis of several bone loss disord
Externí odkaz:
https://doaj.org/article/9530309893c8457f8ee6bedfc723193d
Autor:
Maria G. Ledesma-Colunga, Ulrike Baschant, Heike Weidner, Tiago C. Alves, Peter Mirtschink, Lorenz C. Hofbauer, Martina Rauner
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102616- (2023)
Objective: Rheumatoid arthritis is an inflammatory joint disease in which synovial iron deposition has been described. Transferrin receptor 2 (Tfr2) represents a critical regulator of systemic iron levels. Loss of Tfr2 function in humans and mice res
Externí odkaz:
https://doaj.org/article/b6dfec1e6fe644efb74ea14a924671ec
Autor:
Maik Herbig, Angela Jacobi, Manja Wobus, Heike Weidner, Anna Mies, Martin Kräter, Oliver Otto, Christian Thiede, Marie‑Theresa Weickert, Katharina S. Götze, Martina Rauner, Lorenz C. Hofbauer, Martin Bornhäuser, Jochen Guck, Marius Ader, Uwe Platzbecker, Ekaterina Balaian
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Diagnosis of myelodysplastic syndrome (MDS) mainly relies on a manual assessment of the peripheral blood and bone marrow cell morphology. The WHO guidelines suggest a visual screening of 200 to 500 cells which inevitably turns the assessor b
Externí odkaz:
https://doaj.org/article/47750a67f89b4072ae8b903f4aa9907e
Autor:
Neil Gittoes, Lars Rejnmark, Steven W. Ing, Maria Luisa Brandi, Sigridur Björnsdottir, Stefanie Hahner, Lorenz C. Hofbauer, Pascal Houillier, Aliya A. Khan, Michael A. Levine, Michael Mannstadt, Dolores M. Shoback, Tamara J. Vokes, Pinggao Zhang, Claudio Marelli, John Germak, Bart L. Clarke
Publikováno v:
BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background The PARADIGHM registry of adult and pediatric patients with chronic hypoparathyroidism evaluates the long-term safety and effectiveness of treatment with recombinant human parathyroid hormone, rhPTH(1-84), and describes the clinic
Externí odkaz:
https://doaj.org/article/12c9c84405614bd69518853f175c18a9
Autor:
Daniel Martin Klotz, Jan Dominik Kuhlmann, Theresa Link, Maren Goeckenjan, Lorenz C. Hofbauer, Andy Göbel, Tilman D. Rachner, Pauline Wimberger
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundNeuropilin (NRP) is a transmembrane protein, which has been shown to be a pro-angiogenic mediator and implicated as a potential driver of cancer progression. NRP-1 up-regulation in ovarian cancer tissue predicts poor prognosis. However, the
Externí odkaz:
https://doaj.org/article/03ee71a135cd4b958849b2d257f515b6