Výsledky vyhledávání

Stretch–Activation of Angiotensin II Type 1 a Receptors Contributes to the Myogenic Response of Mouse Mesenteric and Renal Arteries

Autor: Stefanie Weinert, Yoland-Marie Anistan, István András Szijártó, Thomas J. Jentsch, Natalia Alenina, Jean-Yves Tano, Michael Bader, Asif R. Pathan, Nancy J. Rusch, Hantz C. Hercule, Mario Kassmann, Johanna Schleifenbaum, Maik Gollasch, Matthias Heidenreich

Publikováno v: Circulation Research. 115:263-272

Rationale : Vascular wall stretch is the major stimulus for the myogenic response of small arteries to pressure. The molecular mechanisms are elusive, but recent findings suggest that G protein–coupled receptors can elicit a stretch response. Objec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f20768585f2bf941883d2ad683cf200
https://doi.org/10.1161/circresaha.115.302882

Zobrazit plný text záznamu

Interaction Between P450 Eicosanoids and Nitric Oxide in the Control of Arterial Tone in Mice

Autor: Andrey Ch. da Costa Goncalves, Maik Gollasch, Fung Ping Leung, Friedrich C. Luft, Hantz C. Hercule, Steven M. Weldon, Jasmin Seringer, Volkmar Gross, Yu Huang, Wolf-Hagen Schunck

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 29:54-60

Objective— Epoxyeicosatrienoic acids (EETs) serve as endothelial-derived hyperpolarizing factors (EDHF), but may also affect vascular function by other mechanisms. We identified a novel interaction between EETs and endothelial NO release using solu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058c2d8a5a08c524ee43b76ef1a7ed2f
https://doi.org/10.1161/atvbaha.108.171298

Zobrazit plný text záznamu

The vasodilator 17,18-epoxyeicosatetraenoic acid targets the pore-forming BK α channel subunit in rodents

Autor: Friedrich C. Luft, Horst Honeck, Wolf-Hagen Schunck, Kirill Essin, Peter Ruth, Maik Gollasch, John R. Falck, Hantz C. Hercule, Birgit Salanova, Matthias Sausbier

Publikováno v: Experimental Physiology. 92:1067-1076

17,18-Epoxyeicosatetraenoic acid (17,18-EETeTr) stimulates vascular large-conductance K(+) (BK) channels. BK channels are composed of the pore-forming BK alpha and auxiliary BK beta1 subunits that confer an increased sensitivity for changes in membra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18df7c5847b928c6739910fc4b30138e
https://doi.org/10.1113/expphysiol.2007.038166

Zobrazit plný text záznamu

Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice

Autor: Andrey C. da Costa Goncalves, Maren Wellner, Friedrich C. Luft, Volkmar Gross, André Diedrich, Jens Jordan, Hantz C. Hercule, Ralph Plehm, Maik Gollasch, Jens Tank

Publikováno v: Experimental Physiology. 92:1014-1022

Angiotensin II (Ang II) activates signalling pathways predominantly through the G-protein-coupled Ang II type 1 receptor (AT(1)R). The regulator of G protein signalling 2 (RGS2) is a negative G protein regulator. We hypothesized that RGS2 deletion ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d26595722f3fd20406377f6a9fd01b2
https://doi.org/10.1113/expphysiol.2007.038240

Zobrazit plný text záznamu

Alteration in endothelin receptor sub-type responsiveness and in the endothelin–TXA2 mimetic U46619 interaction, in type-2 hypertensive diabetic Zucker rats

Autor: A.A Ajayi, H. C. Hercule, L Mutembei, G.O Ogungbade, Adebayo Oyekan

Publikováno v: Diabetes Research and Clinical Practice. 63:155-169

Type-2 diabetes is characterized by endotheliopathy, which increases target organ damage and mortality. There is excessive endothelin-1 and TXA(2) production, and abnormal vascular reactivity to endothelin-1, manifested as a paradoxical hypotensive a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0615d73d541275d8cf776e7683bec880
https://doi.org/10.1016/j.diabres.2003.09.011

Zobrazit plný text záznamu

Nitric oxide-epoxygenase interactions and arachidonate-induced dilation of rat renal microvessels

Autor: H. Jiang, H. C. Hercule, I. T. Udosen, A. O. Oyekan

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 285:H2054-H2063

Nitric oxide (NO) is an inhibitor of hemoproteins including cytochrome P-450 enzymes. This study tested the hypothesis that NO inhibits cytochrome P-450 epoxygenase-dependent vascular responses in kidneys. In rat renal pressurized microvessels, arach

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef19791f988c1e76d94f3a261b84cea
https://doi.org/10.1152/ajpheart.00075.2003

Zobrazit plný text záznamu

Gender difference in vascular and platelet reactivity to thromboxane A2-mimetic U46619 and to endothelial dependent vasodilation in Zucker fatty (hypertensive, hyperinsulinemic) diabetic rats

Autor: James Cory, Adebayo Oyekan, H. C. Hercule, B.E Hayes, A.A Ajayi

Publikováno v: Diabetes Research and Clinical Practice. 59:11-24

We examined the hypothesis that gender differences exist in platelet and vascular reactivity in type-2 diabetes mellitus, using Zucker fatty diabetic rats of both sexes and their lean littermates. Type-2 diabetes is characterized by excessive platele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac5a5a428d0ff01fc08656789dfb1a7
https://doi.org/10.1016/s0168-8227(02)00180-8

Zobrazit plný text záznamu

Interactions of the Renin–angiotensin System and Alpha-1 Adrenoceptors on Renal Hemodynamics in Healthy and Acute Renal Failure Rats: The Role of Nitric Oxide

Autor: J. Pamugo, A.A Ajayi, Adebayo Oyekan, H. C. Hercule, D. Dixon

Publikováno v: Blood Pressure. 10:238-246

Ajayi AAL, Hercule HC, Pamugo J, Dixon D, Oyekan AO. Interactions of the renin‐angiotensin system and alpha-1 adrenoceptors on renal hemodynamics in healthy and acute renal failure rats: the role of nitric oxide. Blood Pressure 2001; 10: 238‐246.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d517835cd502de887de62d34b7a060c5
https://doi.org/10.1080/08037050152669765

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání