Zobrazeno 1 - 10
of 231
pro vyhledávání: '"C, Gumbart"'
Publikováno v:
ACS Omega, Vol 9, Iss 36, Pp 37843-37855 (2024)
Externí odkaz:
https://doaj.org/article/d4aa199394494f91a742a2f95faf104e
Autor:
Svitlana Babii, Wei Li, Lixinhao Yang, Anna E. Grzegorzewicz, Mary Jackson, James C. Gumbart, Helen I. Zgurskaya
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Infections caused by Mycobacterium spp. are very challenging to treat, and multidrug-resistant strains rapidly spread in human populations. Major contributing factors include the unique physiological features of these bacteria, drug efflux,
Externí odkaz:
https://doaj.org/article/06709d6584f54e528a341c3687c2cd44
Autor:
Kevin Wu, Samuel Itskanov, Diane L. Lynch, Yuanyuan Chen, Aasha Turner, James C. Gumbart, Eunyong Park
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Doa10 (MARCHF6 in metazoans) is a large polytopic membrane-embedded E3 ubiquitin ligase in the endoplasmic reticulum (ER) that plays an important role in quality control of cytosolic and ER proteins. Although Doa10 is highly conserved across
Externí odkaz:
https://doaj.org/article/be2e86f1e3154106b7a2c1e7f41a8492
Autor:
Emily G. Saccuzzo, Mubark D. Mebrat, Hailee F. Scelsi, Minjoo Kim, Minh Thu Ma, Xinya Su, Shannon E. Hill, Elisa Rheaume, Renhao Li, Matthew P. Torres, James C. Gumbart, Wade D. Van Horn, Raquel L. Lieberman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Studies of folded-to-misfolded transitions using model protein systems reveal a range of unfolding needed for exposure of amyloid-prone regions for subsequent fibrillization. Here, we probe the relationship between unfolding and aggregation
Externí odkaz:
https://doaj.org/article/d4c43b083a34447bb38dec82f348044d
Autor:
Benjamin Russell Lewis, Muhammad R. Uddin, Mohammad Moniruzzaman, Katie M. Kuo, Anna J. Higgins, Laila M. N. Shah, Frank Sobott, Jerry M. Parks, Dietmar Hammerschmid, James C. Gumbart, Helen I. Zgurskaya, Eamonn Reading
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Membrane efflux pumps play a major role in bacterial multidrug resistance. The tripartite multidrug efflux pump system from Escherichia coli, AcrAB-TolC, is a target for inhibition to lessen resistance development and restore antibiotic effi
Externí odkaz:
https://doaj.org/article/db36206389534e89aa35837123b7295a
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Molecular dynamics simulations and enhanced sampling methods reveal the role of glycans and the energetics of glycan-mediated conformational switches in the receptor binding domains of the SARS-CoV-2 trimeric spike glycoprotein.
Externí odkaz:
https://doaj.org/article/7dd6b0f1daf445fea34c23d96fb193d8
Autor:
Andras Karsai, Grace J. Cassidy, Aradhya P. Rajanala, Lixinhao Yang, Deniz Kerimoglu, James C. Gumbart, Harold D. Kim, Daniel I. Goldman
Publikováno v:
Frontiers in Physics, Vol 11 (2023)
Recent studies in polymer physics have created macro-scale analogs to solute microscopic polymer chains like DNA by inducing diffusive motion on a chain of beads. These bead chains have persistence lengths of O(10) links and undergo diffusive motion
Externí odkaz:
https://doaj.org/article/2bddc66b2bd449bf9ca7f9f2ef65b88d
Autor:
Runrun Wu, Jeremy W. Bakelar, Karl Lundquist, Zijian Zhang, Katie M. Kuo, David Ryoo, Yui Tik Pang, Chen Sun, Tommi White, Thomas Klose, Wen Jiang, James C. Gumbart, Nicholas Noinaj
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The β-barrel assembly machinery (BAM) assists the folding and membrane insertion of bacterial outer membrane proteins. Here, the authors report structural characterization of BAM in lipid environment and in complex with the client protein EspP integ
Externí odkaz:
https://doaj.org/article/cd323a1040434cb5be239dec28a98476
Autor:
Ilija Uzelac, PhD, MBA, Abouzar Kaboudian, PhD, Shahriar Iravanian, MD, MSE, Jimena G. Siles-Paredes, MSc, James C. Gumbart, PhD, Hiroshi Ashikaga, MD, PhD, Neal Bhatia, MD, FHRS, Robert F. Gilmour, Jr., PhD, Elizabeth M. Cherry, PhD, Flavio H. Fenton, PhD
Publikováno v:
Heart Rhythm O2, Vol 2, Iss 4, Pp 394-404 (2021)
Background: In March 2020, hydroxychloroquine (HCQ) alone or combined with azithromycin (AZM) was authorized as a treatment for COVID-19 in many countries. The therapy proved ineffective with long QT and deadly cardiac arrhythmia risks, illustrating
Externí odkaz:
https://doaj.org/article/d37df8cb8bc64d6f99c1a217a1906901
Autor:
Simen Hermansen, David Ryoo, Marcella Orwick-Rydmark, Athanasios Saragliadis, James C. Gumbart, Dirk Linke
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The outer membrane of Gram-negative bacteria acts as an additional diffusion barrier for solutes and nutrients. It is perforated by outer membrane proteins (OMPs) that function most often as diffusion pores, but sometimes also as parts of larger cell
Externí odkaz:
https://doaj.org/article/0392a8fb9b534a1392e4647e52dd5d3f