Zobrazeno 1 - 10
of 1 523
pro vyhledávání: '"C, Gruber"'
Publikováno v:
Drugs in R&D, Vol 24, Iss 2, Pp 263-274 (2024)
Abstract Background and objectives Tolebrutinib is a covalent BTK inhibitor designed and selected for potency and CNS exposure to optimize impact on BTK-dependent signaling in CNS-resident cells. We applied a translational approach to evaluate three
Externí odkaz:
https://doaj.org/article/4f8986745c8b4847be8e39c282c607d5
Autor:
Michael Hetmann, Lena Parigger, Hassan Sirelkhatim, Abraham Stern, Andreas Krassnigg, Karl Gruber, Georg Steinkellner, David Ruau, Christian C. Gruber
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-13 (2024)
Abstract Human proteins are crucial players in both health and disease. Understanding their molecular landscape is a central topic in biological research. Here, we present an extensive dataset of predicted protein structures for 42,042 distinct human
Externí odkaz:
https://doaj.org/article/e0585cba6d864c839fdc4bcda9c724fd
Autor:
Timothy E. Albertson, Caitlin Hansen, Smiti Bihari, Juleen Gayed, Xia Xu, J. Abraham Simón-Campos, Michael E. Dever, Jose F. Cardona, Essack Mitha, Jeffrey B. Baker, Georgina Keep, Islamiat Oladipupo, Federico J. Mensa, Ye Feng, Hua Ma, Kenneth Koury, Susan Mather, Claudia Ana Ianos, Annaliesa S. Anderson, Özlem Türeci, Uǧur Şahin, William C. Gruber, Alejandra Gurtman, Charu Sabharwal, Nicholas Kitchin, the C4591031, C4591007 Clinical Trial Groups
Publikováno v:
Infectious Diseases and Therapy, Vol 13, Iss 4, Pp 699-714 (2024)
Abstract Introduction Rare myocarditis and pericarditis cases have occurred in coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccine recipients. Troponin levels, a potential marker of myocardial injury, were assessed in healthy participant
Externí odkaz:
https://doaj.org/article/90c062f7697b4812bbed4dc9541f00d7
Autor:
E. Farabi, V.V. Rielli, F. Godor, C. Gruber, A. Stanojevic, B. Oberwinkler, S.P. Ringer, S. Primig
Publikováno v:
Materials & Design, Vol 242, Iss , Pp 112987- (2024)
Alloy 718 is widely used in critical temperature components of modern aircraft engines and gas turbines. However, its industrial-scale forging faces challenges around heterogeneous microstructures and properties in the final product. This has been at
Externí odkaz:
https://doaj.org/article/ceddd522ab7649beb83b3307fb7eabda
Autor:
Yasunori Ishihara, Mitsuru Fukazawa, Shinya Enomoto, Richard de Solom, Masako Yamaji, Mary Kline, Masakazu Aizawa, Yahong Peng, Osamu Kogawara, Peter C. Giardina, Noor Tamimi, William C. Gruber, Wendy Watson
Publikováno v:
International Journal of Infectious Diseases, Vol 141, Iss , Pp 106942- (2024)
Objectives: Safety and immunogenicity evaluation of a 4-dose series with 20-valent pneumococcal conjugate vaccine (PCV20). Methods: This phase 3, double-blind study randomized healthy Japanese infants to receive 4 doses (3 infant doses, 1 toddler dos
Externí odkaz:
https://doaj.org/article/e0e45f2660a14988b484febfbc2f4db8
Autor:
Louise Murdoch, Karen Quan, James A. Baber, Agnes W. Y. Ho, Ying Zhang, Xia Xu, Claire Lu, David Cooper, Kenneth Koury, Stephen P. Lockhart, Annaliesa S. Anderson, Özlem Türeci, Uğur Şahin, Kena A. Swanson, William C. Gruber, Nicholas Kitchin, the C4591030 Clinical Trial Group
Publikováno v:
Infectious Diseases and Therapy, Vol 12, Iss 9, Pp 2241-2258 (2023)
Abstract Introduction Vaccination is a critical tool for preventing coronavirus disease 2019 (COVID-19) and influenza illnesses. Coadministration of the COVID-19 vaccine, BNT162b2, with seasonal inactivated influenza vaccine (SIIV) can provide substa
Externí odkaz:
https://doaj.org/article/c10e41db0b574d23af185c6952e55029
Autor:
Lena Parigger, Andreas Krassnigg, Michael Hetmann, Anna Hofmann, Karl Gruber, Georg Steinkellner, Christian C. Gruber
Publikováno v:
Viruses, Vol 16, Iss 8, p 1186 (2024)
Advancing climate change increases the risk of future infectious disease outbreaks, particularly of zoonotic diseases, by affecting the abundance and spread of viral vectors. Concerningly, there are currently no approved drugs for some relevant disea
Externí odkaz:
https://doaj.org/article/fa0c7a6566a74e07b930b775d15f5420
Autor:
M. Hetmann, C. Langner, V. Durmaz, M. Cespugli, K. Köchl, A. Krassnigg, K. Blaschitz, S. Groiss, M. Loibner, D. Ruau, K. Zatloukal, K. Gruber, G. Steinkellner, C. C. Gruber
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract In this work, we present DrugSolver CavitomiX, a novel computational pipeline for drug repurposing and identifying ligands and inhibitors of target enzymes. The pipeline is based on cavity point clouds representing physico-chemical propertie
Externí odkaz:
https://doaj.org/article/1ae0037bc0e447a5973daa5dfc9b184f
Autor:
Lena Parigger, Andreas Krassnigg, Stefan Grabuschnig, Karl Gruber, Georg Steinkellner, Christian C. Gruber
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT The monkeypox virus (MPX) belongs to the Orthopoxvirus genus of the Poxviridae family, is endemic in parts of Africa and causes a disease in humans similar to smallpox. The most recent outbreak of MPX is already affecting 110 countries, with
Externí odkaz:
https://doaj.org/article/68750fe4bbf941c8a3c6fea06bcdcdad
Autor:
G. Ressel, D. Brandl, T. Hönigmann, M. Lukas, A. Stark, C. Gruber, S. Lukas, M. Stockinger, E. Kozeschnik
Publikováno v:
Materials & Design, Vol 234, Iss , Pp 112370- (2023)
The recrystallization without previous deformation is reported in literature for a small, selected group of alloys. The present work provides evidence for the first time that the commercial stainless steel 15-5 PH also shows this recrystallization ph
Externí odkaz:
https://doaj.org/article/288b2a9ce8bd4df7a49f05d4e5a5d101