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Ghrelin: A Link between Eating Disorders, Obesity and Reproduction

Autor: S. Destefanis, C. Gottero, C. Gauna, A. J. van der Lely, Fabio Broglio, Andrea Benso, Flavia Prodam, S. Bellone, Ezio Ghigo, Emanuela Arvat

Publikováno v: Nutritional Neuroscience. 7:255-270

Ghrelin, a 28-amino acid acylated peptide predominantly produced by the stomach, displays strong GH-releasing activity mediated by the hypothalamic-pituitary GH secretagogues (GHS) receptors (GHS-R) which had been shown specific for a family of synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71e80a61ffa7759af73c6e3b3e0e676
https://doi.org/10.1080/10284150400017363

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Ghrelin Secretion in Childhood Is Refractory to the Inhibitory Effect of Feeding

Autor: Fabio Broglio, N. Castellino, Gianni Bona, Simonetta Bellone, J. Bellone, Giorgio Radetti, Daniela Vivenza, Anna Rapa, C. Gottero, Ezio Ghigo

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 89:1662-1665

Ghrelin, a natural GH secretagogue, is predominantly produced by the stomach. Ghrelin has other actions including orexant activity, modulation of energy balance, and modulation of endocrine and nonendocrine functions. Ghrelin secretion is increased b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230515d183b99907d59e186a87f745c8
https://doi.org/10.1210/jc.2003-031207

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Cortistatin-17 and -14 exert the same endocrine activities as somatostatin in humans

Autor: C. Gottero, L. Filtri, Flavia Prodam, Andrea Benso, Ezio Ghigo, S. Destefanis, Fabrizio Riganti, A. J. van der Lely, Fabio Broglio, C. Gauna, E. Me

Publikováno v: Growth Hormone and IGF Research, 14, 382-387. Elsevier Ltd.

Cortistatin (CST) is a neuropeptide, which binds with high affinity all somatostatin (SS) receptor subtypes and shows high structural homology with SS itself. A receptor specific for CST only, i.e., not recognized by SS, has been recently described i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8f452c9670e5024b31afafb153185b
https://doi.org/10.1016/j.ghir.2004.04.003

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Acetylcholine regulates ghrelin secretion in humans

Autor: Fabio Broglio, Aart Jan van der Lely, C. Gottero, Leo J. Hofland, C. Gauna, Emanuela Arvat, Peter M. van Koetsveld, Ezio Ghigo, Andrea Benso, Flavia Prodam, S. Destefanis

Publikováno v: Journal of Clinical Endocrinology and Metabolism, 89(5), 2429-2433. Endocrine Society

Ghrelin secretion has been reportedly increased by fasting and energy restriction but decreased by food intake, glucose, insulin, and somatostatin. However, its regulation is still far from clarified. The cholinergic system mediates some ghrelin acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ac850642daba04e3d6c4f9ef9c56da
https://pure.eur.nl/en/publications/d6204df8-6661-45fd-bd4c-64820246a7c1

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Ghrelin does not mediate the somatotroph and corticotroph responses to the stimulatory effect of glucagon or insulin-induced hypoglycaemia in humans

Autor: Andreea Picu, Emanuela Arvat, C. Gottero, Ezio Ghigo, M. Balbo, Fabio Broglio, E. Me, Roberta Giordano, Flavia Prodam, Aart Jan van der Lely, S. Destefanis, Fabrizio Riganti

Publikováno v: Clinical Endocrinology, 60, 699-704. Wiley-Blackwell Publishing Ltd

Summary objective Acylated ghrelin, a gastric peptide, possesses a potent GH- but also significant ACTH/cortisol-releasing activity mediated by the activation of GH secretagogue receptors (GHS-R) at the hypothalamus–pituitary level. The physiologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308fe64528f5d21248248e65c8952350
https://doi.org/10.1111/j.1365-2265.2004.02038.x

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Ghrelin secretion is inhibited by glucose load and insulin-induced hypoglycaemia but unaffected by glucagon and arginine in humans

Autor: Aart Jan van der Lely, C. Gottero, Gianni Bona, Flavia Prodam, Fabrizio Riganti, E. Me, Anna Rapa, V. Martina, Daniela Vivenza, S. Destefanis, Fabio Broglio, C. Gauna, Emanuela Arvat, Ezio Ghigo

Publikováno v: Clinical Endocrinology, 61, 503-509. Wiley-Blackwell Publishing Ltd

Summary objective Circulating ghrelin levels are increased by fasting and decreased by feeding, glucose load, insulin and somatostatin. Whether hyperglycaemia and insulin directly inhibit ghrelin secretion still remains matter of debate. The aim of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83e2f6c13c0bea8dec52d0969fdebb2
https://doi.org/10.1111/j.1365-2265.2004.02121.x

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Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans

Autor: Mauro Papotti, Thierry Abribat, Giampiero Muccioli, A. J. van der Lely, C. Gottero, Fabio Broglio, Flavia Prodam, C. Gauna, Ezio Ghigo

Publikováno v: Journal of Clinical Endocrinology and Metabolism, 89(6), 3062-3065. Endocrine Society

Ghrelin possesses strong GH-releasing activity but also other endocrine activities including stimulation of PRL and ACTH secretion, modulation of insulin secretion and glucose metabolism. It is assumed that the GH secretagogue (GHS) receptor (GHS-R)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f627b65be42714cb477abafadd3fbec
https://pure.eur.nl/en/publications/c4064650-915a-49b8-9431-7369f53d4dcf

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The endocrine response to acute ghrelin administration is blunted in patients with anorexia nervosa, a ghrelin hypersecretory state

Autor: S. Destefanis, C. Gottero, Secondo Fassino, Leo J. Hofland, G. Abbate Daga, Laura Gianotti, Fabio Broglio, C. Gauna, A. J. van der Lely, Fabio Lanfranco, Ezio Ghigo, Valeria Mondelli

Publikováno v: Clinical Endocrinology, 60, 592-599. Wiley-Blackwell Publishing Ltd

OBJECTIVE Ghrelin, a gastric-derived natural ligand of the GH secretagogue (GHS)-receptor (GHS-R), strongly stimulates GH secretion but also possesses other neuroendocrine actions, stimulates food intake and modulates the endocrine pancreas and energ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84000ab5c30701940194efca1c31c4ca
https://hdl.handle.net/1765/60068

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Effects of cortistatin-14 and somatostatin-14 on the endocrine response to hexarelin in humans

Autor: C. Gauna, Flavia Prodam, A. J. van der Lely, Andrea Benso, S. Destefanis, Romano Deghenghi, Fabio Broglio, Ezio Ghigo, L. Filtri, C. Gottero

Publikováno v: Università degli Studi del Piemonte Orientale-IRIS

Cortistatin (CST)-14, a neuropeptide with high structural homology with somatostatine (SS)-14, binds all SS receptor subtypes but also shows activities not shared by SS. CST and SS are often co-expressed in the same neurons but are regulated by diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16affb651e610a8d12462328897046aa
https://doi.org/10.1007/bf03347014

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Effects of Ghrelin on the insulin and glycemic responses to glucose, arginine, or free fatty acids load in humans

Autor: Fabio Broglio, A. J. van der Lely, Romano Deghenghi, Andrea Benso, C. Gottero, C. Gauna, S. Destefanis, Flavia Prodam, M. Maccario, Ezio Ghigo

Publikováno v: Journal of Clinical Endocrinology and Metabolism, 88(9), 4268-4272. Endocrine Society

Ghrelin possesses central and peripheral endocrine actions including influence on the endocrine pancreatic function. To clarify this latter ghrelin action, in seven normal young subjects [age (mean +/- SEM), 28.3 +/- 3.1 yr; body mass index, 21.9 +/-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2f2f5260f070c97bf435636c741bd3
https://hdl.handle.net/1765/31815

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