Zobrazeno 1 - 10
of 228
pro vyhledávání: '"C, Goosen"'
Autor:
Jian Lin, Francois Gaudreault, Nathaniel Johnson, Zhiwu Lin, Parya Nouri, Theunis C. Goosen, Aarti Sawant‐Basak
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 9, Pp 2184-2194 (2022)
Abstract PF‐05251749 is a dual inhibitor of casein kinase 1 δ/ε under clinical development to treat disruption of circadian rhythm in Alzheimer's and Parkinson's diseases. In vitro, PF‐05251749 (0.3–100 μM) induced CYP3A in cryopreserved hum
Externí odkaz:
https://doaj.org/article/3acb9acbeb5d41ab87d83417884bfb90
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 127-136 (2021)
The sodium‐glucose cotransporter 2 inhibitor ertugliflozin is metabolized by the uridine 5'‐diphospho‐glucuronosyltransferase (UGT) isozymes UGT1A9 and UGT2B4/2B7. This analysis evaluated the drug–drug interaction (DDI) following co‐adminis
Externí odkaz:
https://doaj.org/article/eb9d11a32b87407ab4a97d4886d3051e
Autor:
Angela C. Doran, Alyssa L. Dantonio, Gabrielle M. Gualtieri, Amanda Balesano, Connor Landers, Woodrow Burchett, Theunis C. Goosen, R. Scott Obach
Publikováno v:
Drug Metabolism and Disposition. 50:1272-1286
Cytochrome P450 reaction phenotyping to determine the fraction of metabolism values (f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d75f4c59170879ccb0e19a61073e75
https://doi.org/10.1124/dmd.122.000883
https://doi.org/10.1124/dmd.122.000883
Autor:
Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra, Martin E. Dowty
Publikováno v:
Drug Metabolism and Disposition. 50:1106-1118
Abrocitinib is an oral once-daily Janus kinase 1 selective inhibitor being developed for the treatment of moderate-to-severe atopic dermatitis. This study examined the disposition of abrocitinib in male participants following oral and intravenous adm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926208d526384181f37cc80f92c02aa6
https://doi.org/10.1124/dmd.122.000829
https://doi.org/10.1124/dmd.122.000829
Autor:
Heather Eng, Theunis C. Goosen, Jian Lin, Matthew A. Cerny, R. Scott Obach, Elaine E. Tseng, David A. Tess
Publikováno v:
Drug Metabolism and Disposition. 49:947-960
Cytochrome P450 3A (CYP3A) is a frequent target for time-dependent inhibition (TDI) that can give rise to drug-drug interactions (DDI). Yet many drugs that exhibit in vitro TDI for CYP3A do not result in DDI. There were 23 drugs with published clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803b29b300056a42da5a7eb10db6e944
https://doi.org/10.1124/dmd.121.000497
https://doi.org/10.1124/dmd.121.000497
Autor:
C. Goosen, S. Proost, R.Y. Tito, J. Baumgartner, S.L. Barnabas, M.F. Cotton, M.B. Zimmermann, J. Raes, R. Blaauw
Publikováno v:
Clinical Nutrition ESPEN. 54:668
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48701e1b65cecddd1547d10836338d93
https://doi.org/10.1016/j.clnesp.2022.09.615
https://doi.org/10.1016/j.clnesp.2022.09.615
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 2, Pp 127-136 (2021)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
The sodium-glucose cotransporter 2 inhibitor ertugliflozin is metabolized by the uridine 5'-diphospho-glucuronosyltransferase (UGT) isozymes UGT1A9 and UGT2B4/2B7. This analysis evaluated the drug-drug interaction (DDI) following co-administration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4d96f6c1e54241999ac0829b9886f8
https://doaj.org/article/eb9d11a32b87407ab4a97d4886d3051e
https://doaj.org/article/eb9d11a32b87407ab4a97d4886d3051e
Autor:
Angela C. Doran, Woodrow Burchett, Connor Landers, Gabrielle M. Gualtieri, Amanda Balesano, Heather Eng, Alyssa L Dantonio, Theunis C. Goosen, R. Scott Obach
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals.
The utility of chemical inhibitors in cytochrome P450 (CYP) reaction phenotyping is highly dependent on their selectivity and potency for their target CYP isoforms. In the present study, seventeen inhibitors of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, and 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fdb54fca7319cb247bf9771b45d19f
https://pubmed.ncbi.nlm.nih.gov/35777846
https://pubmed.ncbi.nlm.nih.gov/35777846
Autor:
Heidi J. Einolf, Barry Jones, Phillip D. Yates, Theunis C. Goosen, Diane Ramsden, Conrad Fung, Y. Amy Siu, Niresh Hariparsad, Simon Wong, Liangfu Chen, Jairam Palamanda, George Zhang, Donald J. Tweedie, Shannon Dallas
Publikováno v:
Drug Metabolism and Disposition. 49:94-110
Translational and ADME Sciences Leadership Group Induction Working Group (IWG) presents an analysis on the time course for cytochrome P450 induction in primary human hepatocytes. Induction of CYP1A2, CYP2B6, and CYP3A4 was evaluated by seven IWG labo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa020936133a247e86ba65e02dc01b76
https://doi.org/10.1124/dmd.120.000055
https://doi.org/10.1124/dmd.120.000055
Publikováno v:
Florida Public Health Review, Vol 7, Pp 106-110 (2010)
In the U.S., obesity is recognized as a growing epidemic whose increased prevalence among adults, children and adolescents present major health concerns. It is the second leading cause of preventable death, surpassed only by tobacco use. Research ind
Externí odkaz:
https://doaj.org/article/9710a3b663db4477bd91592094c9376a