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Akademický článek

Protein mimetic 2D FAST rescues alpha synuclein aggregation mediated early and post disease Parkinson’s phenotypes

Autor: Nicholas H. Stillman, Johnson A. Joseph, Jemil Ahmed, Charles Zuwu Baysah, Ryan A. Dohoney, Tyler D. Ball, Alexandra G. Thomas, Tessa C. Fitch, Courtney M. Donnelly, Sunil Kumar

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)

Abstract Abberent protein-protein interactions potentiate many diseases and one example is the toxic, self-assembly of α-Synuclein in the dopaminergic neurons of patients with Parkinson’s disease; therefore, a potential therapeutic strategy is the

Externí odkaz: https://doaj.org/article/33653df251db405bb66003cb7c1cf223

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Akademický článek

43 Severe maternal morbidity is increased among pregnant persons with gynecological malignancies

Autor: Katherine C. Fitch, Christine G.T. Nguyen, Ann M. Cathcart, Hersh Alyssa, Bharti Garg, Jenna Emerson, Aaron Caughey

Publikováno v: Gynecologic Oncology Reports, Vol 48, Iss , Pp S23- (2023)

Objectives: In this study, we sought to examine whether pregnant individuals diagnosed with a gynecologic malignancy experienced higher rates of severe maternal morbidity (SMM). Methods: This was a retrospective cohort study of deliveries at 23 to 42

Externí odkaz: https://doaj.org/article/7bf4eef5ca9c427d81662ec9b2a6d69d

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Akademický článek

Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly

Autor: Jemil Ahmed, Tessa C. Fitch, Courtney M. Donnelly, Johnson A. Joseph, Tyler D. Ball, Mikaela M. Bassil, Ahyun Son, Chen Zhang, Aurélie Ledreux, Scott Horowitz, Yan Qin, Daniel Paredes, Sunil Kumar

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Inhibiting alpha-synuclein self-assembly into amyloid structures, associated with Parkinson’s disease, is a potential therapeutic intervention. Here, the authors identify the domains/sequences that are essential for alpha-synuclein aggregation and

Externí odkaz: https://doaj.org/article/90b6ab61face4e2e9229b5bec4e05f95

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Akademický článek

Low Diversity and Instability of the Sinus Microbiota over Time in Adults with Cystic Fibrosis

Autor: Catherine R. Armbruster, Kelvin Li, Megan R. Kiedrowski, Anna C. Zemke, Jeffrey A. Melvin, John Moore, Samar Atteih, Adam C. Fitch, Matthew DuPont, Christopher D. Manko, Madison L. Weaver, Jordon R. Gaston, John F. Alcorn, Alison Morris, Barbara A. Methé, Stella E. Lee, Jennifer M. Bomberger

Publikováno v: Microbiology Spectrum, Vol 10, Iss 5 (2022)

ABSTRACT Chronic rhinosinusitis (CRS) is a common, yet underreported and understudied manifestation of upper respiratory disease in people with cystic fibrosis (CF). Recently developed standard of care guidelines for the management of CF CRS suggest

Externí odkaz: https://doaj.org/article/7a2bc36f5e39472e9ab36c7cf0ad33b9

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Akademický článek

Dimethyl Fumarate Blocks Tumor Necrosis Factor-Alpha-Driven Inflammation and Metabolic Rewiring in the Retinal Pigment Epithelium

Autor: Daisy Y. Shu, Scott I. Frank, Tessa C. Fitch, Margarete M. Karg, Erik R. Butcher, Emmanuella Nnuji-John, Leo A. Kim, Magali Saint-Geniez

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)

The retinal pigment epithelium (RPE) acts as a metabolic gatekeeper between photoreceptors and the choroidal vasculature to maintain retinal function. RPE dysfunction is a key feature of age-related macular degeneration (AMD), the leading cause of bl

Externí odkaz: https://doaj.org/article/3648d0b4c0e048b698aee8e295c6130e

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HPV self-collection: what are we waiting for? Exploration of attitudes from frontline healthcare providers

Autor: Jacqueline A Bohn, Katherine C Fitch, Jessica J Currier, Amanda Bruegl

Publikováno v: International Journal of Gynecologic Cancer. 32:1519-1523

ObjectivePolymerase chain reaction based human papilloma virus (HPV) self-collection for cervical cancer screening is well established. It is utilized worldwide, accepted by patients, is cost-effective, has comparable sensitivity to provider-collecte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7732079187c0799a85fef82b5133d0fa
https://doi.org/10.1136/ijgc-2022-003860

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SGRN: A Cas12a-driven Synthetic Gene Regulatory Network System

Autor: HyunJin Kang, John C. Fitch, Reeba P. Varghese, Curtis A. Thorne, Darren A. Cusanovich

Gene regulatory networks, which control gene expression patterns in development and in response to stimuli, use regulatory logic modules to coordinate inputs and outputs. One example of a regulatory logic module is the gene regulatory cascade (GRC),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1110c98c199b3835294210a6f712ffee
https://doi.org/10.1101/2023.05.08.539911

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Akademický článek

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