Zobrazeno 1 - 10 of 33 pro vyhledávání: '"C, Füller"'
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Analysis of long-term persistence of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir
Autor: Simone Susser, Johannes Vermehren, D. Perner, Christoph Sarrazin, C. Füller, Natalia Grigorian, Nicole Forestier, Martin W. Welker, Stefan Zeuzem
Publikováno v: Journal of Clinical Virology. 52:321-327
a b s t r a c t Background: Telaprevir and boceprevir are highly selective hepatitis C virus (HCV) NS3/4A protea- seinhibitors in phase 3 development. Viral breakthrough during mono- and triple-therapies with PEG-interferon and ribavirin and relapse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542661fb0f6e9e65f5b19bcae9acbb1a
https://doi.org/10.1016/j.jcv.2011.08.015
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5
Deep sequencing reveals mutagenic effects of ribavirin during monotherapy of hepatitis C virus genotype 1-infected patients
Autor: Sven-Eric Schelhorn, Thomas Lengauer, Christoph Sarrazin, Thomas Berg, Stefan Zeuzem, Eva Herrmann, Simone Susser, Martin Daumer, Ulrike Mihm, Daniel Fitting, Julia Dietz, C. Füller, Gerlinde Teuber, Martin-Walter Welker, Heiner Wedemeyer
Publikováno v: Journal of virology. 87(11)
The preeminent mode of action of the broad-spectrum antiviral nucleoside ribavirin in the therapy of chronic hepatitis C is currently unresolved. Particularly under contest are possible mutagenic effects of ribavirin that may lead to viral extinction
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b86fb56660b8e1312c430f0595be32
https://pubmed.ncbi.nlm.nih.gov/23536652
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7
Modulation of replication efficacy of the hepatitis C virus replicon Con1 by site-directed mutagenesis of an NS4B aminoterminal basic leucine zipper
Autor: M-W, Welker, S, Susser, C, Welsch, D, Perner, C, Füller, B, Kronenberger, E, Herrmann, S, Zeuzem, C, Sarrazin
Publikováno v: Journal of viral hepatitis. 19(11)
The hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is assumed to function as a membrane anchor and protein hub for the viral replication complex. The aim of the current work was to modulate HCV replication efficacy in the subgenomic Con1 rep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c0b1ec7dd9c24bad953aac45e4f39cd1
https://pubmed.ncbi.nlm.nih.gov/23043384
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8
Serum microRNA-122 kinetics in patients with chronic hepatitis C virus infection during antiviral therapy
Autor: Verena Köberle, Albrecht Piiper, C. Füller, A. Andrei, Bernd Kronenberger, Simone Susser, Christoph Sarrazin, Stefan Zeuzem, D. Perner, Oliver Waidmann
Publikováno v: Journal of viral hepatitis. 20(8)
Summary The levels of the liver-specific microRNA-122 (miR-122) circulating extracellularly in the blood have been shown to be increased upon liver damage. However, it is unknown if the levels of serum miR-122 are altered during antiviral therapy and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db32aa0f5308cca500e1939e85cdfda
https://pubmed.ncbi.nlm.nih.gov/23808991
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