Výsledky vyhledávání

Tumor necrosis factor-alpha-promoted expression of Bcl-2 and inhibition of mitochondrial cytochrome c release mediate resistance of mature dendritic cells to melanoma-induced apoptosis

Autor: C, Esche, G V, Shurin, J M, Kirkwood, G Q, Wang, H, Rabinowich, G, Pirtskhalaishvili, M R, Shurin

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7

Melanoma escapes host defenses through a variety of means, including the elimination of immune effector cells within the tumor microenvironment. We have reported recently that murine and human tumors including melanoma induce premature apoptosis of d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2cb319b1bb2b2c2fc28d35e08df4b69
https://pubmed.ncbi.nlm.nih.gov/11300499

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The use of dendritic cells for cancer vaccination

Autor: C, Esche, M R, Shurin, M T, Lotze

Publikováno v: Current opinion in molecular therapeutics. 1(1)

Dendritic cells (DC) are the most potent antigen presenting cells (APC) and the only ones capable of presenting novel antigens to naïve T-cells. Large numbers of DC can be generated in vitro in the presence of appropriate cytokine cocktails using ei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fd0bd4e59fb17d8bd5597491efd7ec97
https://pubmed.ncbi.nlm.nih.gov/11249687

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Interleukin-12 and Flt3 ligand differentially promote dendropoiesis in vivo

Autor: C, Esche, Q, Cai, J M, Peron, O, Hunter, V M, Subbotin, M T, Lotze, M R, Shurin

Publikováno v: European journal of immunology. 30(9)

Interleukin-12 (IL-12) and Flt3 ligand (FL) regulate hematopoiesis by stimulating proliferation, differentiation and migration of progenitor and/or stem cells. In this study, we evaluated the in vivo effect of IL-12 alone or in combination with FL on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d5beac7c224085d4bc347f81bfd646a4
https://pubmed.ncbi.nlm.nih.gov/11009090

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Cytokine-based therapy for melanoma: pre-clinical studies

Autor: M R, Shurin, J M, Kirkwood, C, Esche

Publikováno v: Forum (Genoa, Italy). 10(3)

Incidence and mortality of human malignant melanoma has risen rapidly over recent decades. Systemic therapies for metastatic cutaneous melanoma, the most aggressive of all skin cancers, remain disappointing although immunological treatment has been m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f8494e37a073d30469e8f555d9b9f3c
https://pubmed.ncbi.nlm.nih.gov/11007930

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Interleukin-2: developing additional cytokine gene therapies using fibroblasts or dendritic cells to enhance tumor immunity

Autor: M T, Lotze, M, Shurin, C, Esche, H, Tahara, W, Storkus, J M, Kirkwood, T L, Whiteside, E M, Elder, H, Okada, P, Robbins

Publikováno v: The cancer journal from Scientific American. 6

Recombinant interleukin (IL)-2 administration can mediate regression of solid tumors in patients with melanoma and renal cell carcinoma. A better understanding of the mechanisms of IL-2-mediated antitumor effects has led to the investigation of novel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d79a3035057f55c01f968d2d6c5121b1
https://pubmed.ncbi.nlm.nih.gov/10685662

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Effect of vascular endothelial growth factor and FLT3 ligand on dendritic cell generation in vivo

Autor: J E, Ohm, M R, Shurin, C, Esche, M T, Lotze, D P, Carbone, D I, Gabrilovich

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(6)

The cytokine FLT3 ligand (FL) enhances dendritic cell (DC) generation and has therefore been proposed as a means to boost antitumor immunity. Vascular endothelial growth factor (VEGF) is produced by a large percentage of tumors and is required for de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1579d6013c5c16a2b0bc66db180859bf
https://pubmed.ncbi.nlm.nih.gov/10477595

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CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth

Autor: C, Esche, A, Gambotto, Y, Satoh, V, Gerein, P D, Robbins, S C, Watkins, M T, Lotze, M R, Shurin

Publikováno v: European journal of immunology. 29(7)

We have recently demonstrated that murine and human tumors induce apoptosis of dendritic cells (DC). Here, we evaluated the effect of CD40 ligation on the survival of tumor-associated DC and tumor growth. Retroviral transduction of MC38 colon carcino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::299abc1b28d7a2600fe4ebf4e2ae3f8e
https://pubmed.ncbi.nlm.nih.gov/10427977

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