Development of an automated mass spectrometry system for the quantitative analysis of liver microsomal incubation samples: a tool for rapid screening of new compounds for metabolic stability

Autor: W A, Korfmacher, C A, Palmer, C, Nardo, K, Dunn-Meynell, D, Grotz, K, Cox, C C, Lin, C, Elicone, C, Liu, E, Duchoslav

Publikováno v: Rapid communications in mass spectrometry : RCM. 13(10)

There is a continuing need for increased throughput in the evaluation of new drug entities in terms of their pharmacokinetic parameters. One useful parameter that can be measured in vitro using liver microsomal preparations is metabolic stability. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d7722b992db1e006076f9716851de07a
https://pubmed.ncbi.nlm.nih.gov/10353225

Beyond Conventional Drug Design: Exploring the Broad-Spectrum Efficacy of Antimicrobial Peptides.

Autor: Odunitan TT; Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria.; Genomics Unit, Helix Biogen Institute, Ogbomosho, Nigeria., Apanisile BT; Department of Nutrition and Dietetics, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria., Afolabi JA; Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria., Adeniwura PO; Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria., Akinboade MW; Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria.; Genomics Unit, Helix Biogen Institute, Ogbomosho, Nigeria., Ibrahim NO; Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria., Alare KP; Department of Medicine and Surgery, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria., Saibu OA; Department of Chemistry and Biochemistry, New Mexico State University, USA, Ibadan., Adeosun OA; Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria., Opeyemi HS; Department of Physiology, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria., Ayiti KS; Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria.

Publikováno v: Chemistry & biodiversity [Chem Biodivers] 2024 Oct 31, pp. e202401349. Date of Electronic Publication: 2024 Oct 31.

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