Zobrazeno 1 - 10
of 352
pro vyhledávání: '"C, Dumitru"'
Autor:
Amaury Stommen, Marine Ghodsi, Anne-Sophie Cloos, Louise Conrard, Andra C. Dumitru, Patrick Henriet, Christophe E. Pierreux, David Alsteens, Donatienne Tyteca
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 51 (2023)
Piezo1 is a mechanosensitive ion channel required for various biological processes, but its regulation remains poorly understood. Here, we used erythrocytes to address this question since they display Piezo1 clusters, a strong and dynamic cytoskeleto
Externí odkaz:
https://doaj.org/article/6f6df9e4557547c3bcc459ac8a573a93
Autor:
Melanie Koehler, Simon J. L. Petitjean, Jinsung Yang, Pavithra Aravamudhan, Xayathed Somoulay, Cristina Lo Giudice, Mégane A. Poncin, Andra C. Dumitru, Terence S. Dermody, David Alsteens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Reovirus endocytosis depends on junctional adhesion molecule A (JAM-A) and β1 integrin binding. Here, Koehler et al. use single-virus force spectroscopy and confocal microscopy to demonstrate a direct interaction between reovirus and β1 integrins v
Externí odkaz:
https://doaj.org/article/3a1ab7363b9f44ae9cb1014c0cfba8dc
Autor:
Andra C. Dumitru, R. N. V. Krishna Deepak, Heng Liu, Melanie Koehler, Cheng Zhang, Hao Fan, David Alsteens
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Dumitru et al. probe the ligand-binding mechanism and activation of the human G protein-coupled C5a receptor (C5aR) and discover a cooperativity between the two orthosteric binding sites. Their findings, probing the dynamic aspects of receptor–liga
Externí odkaz:
https://doaj.org/article/443aebd51a024799afe9304b404255fe
Autor:
Jinsung Yang, Simon J. L. Petitjean, Melanie Koehler, Qingrong Zhang, Andra C. Dumitru, Wenzhang Chen, Sylvie Derclaye, Stéphane P. Vincent, Patrice Soumillion, David Alsteens
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
SARS-CoV-2 spike protein binds host ACE2 for virus entry. Here, the authors determine kinetic and thermodynamic properties of this interaction using atomic force microscopy, develop peptides that inhibit binding and suggest existence of additional at
Externí odkaz:
https://doaj.org/article/22063247702e4aba8bea199d3422791c
Autor:
Claire Valotteau, Andra C. Dumitru, Laurence Lecordier, David Alsteens, Etienne Pays, David Pérez-Morga, Yves F. Dufrêne
Publikováno v:
ACS Omega, Vol 5, Iss 33, Pp 20953-20959 (2020)
Externí odkaz:
https://doaj.org/article/610f45d5084c4d4b81c8b249f83b1077
Autor:
Melanie Koehler, Pavithra Aravamudhan, Camila Guzman-Cardozo, Andra C. Dumitru, Jinsung Yang, Serena Gargiulo, Patrice Soumillion, Terence S. Dermody, David Alsteens
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The reovirus outercapsid protein σ1 binds to α-linked sialic acid and junctional adhesion molecule A (JAM-A) for virus entry. Here, combining atomic force microscopy and confocal microscopy, the authors provide insights into the dynamics of these i
Externí odkaz:
https://doaj.org/article/18f1c9f75cb84361a7d2dc3c6a719136
Autor:
Anne-Sophie Cloos, Laura G. M. Daenen, Mauriane Maja, Amaury Stommen, Juliette Vanderroost, Patrick Van Der Smissen, Minke Rab, Jan Westerink, Eric Mignolet, Yvan Larondelle, Romano Terrasi, Giulio G. Muccioli, Andra C. Dumitru, David Alsteens, Richard van Wijk, Donatienne Tyteca
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Familial hypobetalipoproteinemia is a metabolic disorder mainly caused by mutations in the apolipoprotein B gene. In its homozygous form it can lead without treatment to severe ophthalmological and neurological manifestations. In contrast, the hetero
Externí odkaz:
https://doaj.org/article/06470655076b47c5982e9ae8553009a9
Autor:
Andra C. Dumitru, Danahe Mohammed, Mauriane Maja, Jinsung Yang, Sandrine Verstraeten, Aranzazu del Campo, Marie‐Paule Mingeot‐Leclercq, Donatienne Tyteca, David Alsteens
Publikováno v:
Advanced Science, Vol 7, Iss 22, Pp n/a-n/a (2020)
Abstract Tumor cells present profound alterations in their composition, structural organization, and functional properties. A landmark of cancer cells is an overall altered mechanical phenotype, which so far are linked to changes in their cytoskeleta
Externí odkaz:
https://doaj.org/article/7a3079f341ea4bacb62f0fa3f1a29373
Autor:
Jinsung Yang, Simon J. L. Petitjean, Melanie Koehler, Qingrong Zhang, Andra C. Dumitru, Wenzhang Chen, Sylvie Derclaye, Stéphane P. Vincent, Patrice Soumillion, David Alsteens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/1ba3ed91a8174383a81a4edd4703b94e
Autor:
Andra C. Dumitru, R. N. V. Krishna Deepak, Heng Liu, Melanie Koehler, Cheng Zhang, Hao Fan, David Alsteens
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/766d39bf1df34b0ba932d3d31fbe643e