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Fractionation platform for target identification using off-line directed two-dimensional chromatography, mass spectrometry and nuclear magnetic resonance

Autor: John P. M. van Duynhoven, Doris M. Jacobs, Hyung Elfrink, Ulrich Braumann, Tom van der Laan, Aldrik H. Velders, A. C. Dubbelman, Amy C. Harms, Fatemeh Azadi-Chegeni, Thomas Hankemeier

Publikováno v: Analytica Chimica Acta 1142 (2021)
Analytica Chimica Acta, 1142, 28-37
Analytica Chimica Acta

The unambiguous identification of unknown compounds is of utmost importance in the field of metabolomics. However, current identification workflows often suffer from error-sensitive methodologies, which may lead to incorrect structure annotations of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d5b829aba356121a108f6f4f83c63a
https://research.wur.nl/en/publications/fractionation-platform-for-target-identification-using-off-line-d

High-Throughput Fractionation Coupled to Mass Spectrometry for Improved Quantitation in Metabolomics

Autor: Thomas Hankemeier, Tom van der Laan, Alida S.D. Kindt, A. C. Dubbelman, Kevin Duisters, Amy C. Harms

Publikováno v: Analytical Chemistry

Metabolomics is emerging as an important field in life sciences. However, a weakness of current mass spectrometry (MS) based metabolomics platforms is the time-consuming analysis and the occurrence of severe matrix effects in complex mixtures. To ove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e102aaec0703b07138a720691479ccf0
https://pubmed.ncbi.nlm.nih.gov/33054161

Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum

Autor: Alida S.D. Kindt, Tom van der Laan, Thomas Hankemeier, A. C. Dubbelman, P. Eline Slagboom, Marian Beekman, Cornelia M. van Duijn, Amy C. Harms, Tim Kloots

Publikováno v: Scientific Reports, 9, 12370. NATURE PUBLISHING GROUP
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports, 9
Scientific Reports, 9:12370. Nature Publishing Group

In the past few years, the gut microbiome has been shown to play an important role in various disorders including in particular cardiovascular diseases. Especially the metabolite trimethylamine-N-oxide (TMAO), which is produced by gut microbial metab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04780538aa51af8ff53efdf1ded73d6
https://hdl.handle.net/1887/120378

Mass spectrometric recommendations for Quan/Qual analysis using liquid-chromatography coupled to quadrupole time-of-flight mass spectrometry

Autor: Rob J. Vreeken, Lieve Dillen, A. C. Dubbelman, Gross Gerhard Max, Filip Cuyckens, Thomas Hankemeier

Publikováno v: Analytica Chimica Acta
Analytica Chimica Acta, 1020, 62-75

High-throughput simultaneous quantitative and qualitative (Quan/Qual) analysis is attractive to combine targeted with non-targeted analysis, e.g. in pharmacometabolomics and drug metabolism studies. This study aimed to investigate the possibilities a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f242c9f9b018fc0e8bdeced2abf347a
https://doi.org/10.1016/j.aca.2018.02.055